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Licensed Unlicensed Requires Authentication Published by De Gruyter February 23, 2017

Sleep-related breathing biomarkers as a predictor of vital functions

  • Klaudia Proniewska EMAIL logo , Agnieszka Pregowska and Krzysztof Piotr Malinowski

Abstract

Because an average human spends one third of his life asleep, it is apparent that the quality of sleep has an important impact on the overall quality of life. To properly understand the influence of sleep, it is important to know how to detect its disorders such as snoring, wheezing, or sleep apnea. The aim of this study is to investigate the predictive capability of a dual-modality analysis scheme for methods of sleep-related breathing disorders (SRBDs) using biosignals captured during sleep. Two logistic regressions constructed using backward stepwise regression to minimize the Akaike information criterion were extensively considered. To evaluate classification correctness, receiver operating characteristic (ROC) curves were used. The proposed classification methodology was validated with constructed Random Forests methodology. Breathing sounds and electrocardiograms of 15 study subjects with different degrees of SRBD were captured and analyzed. Our results show that the proposed classification model based on selected parameters for both logistic regressions determine the different types of acoustic events during sleep. The ROC curve indicates that selected parameters can distinguish normal versus abnormal events during sleep with high sensitivity and specificity. The percentage of prediction for defined SRBDs is very high. The initial assumption was that the quality of result is growing with the number of parameters included in the model. The best recognition reached is more than 89% of good predictions. Thus, sleep monitoring of breath leads to the diagnosis of vital function disorders. The proposed methodology helps find a way of snoring rehabilitation, makes decisions concerning future treatment, and has an influence on the sleep quality.

Acknowledgments

This paper has been partially supported by the Lesser Enterprise Center. The authors thank the AGH University of Science and Technology for outstanding technical assistance.

  1. Author contributions: The authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: The Lesser Enterprise Center.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2017-1-15
Accepted: 2017-1-23
Published Online: 2017-2-23
Published in Print: 2017-3-1

©2017 Walter de Gruyter GmbH, Berlin/Boston

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