Abstract
The development of organic reactions that covalently modify biological matter in complex biological mixtures has become an invaluable asset in drug discovery. Out of the techniques developed to date, optically controlled chemistries are of particular utility owing to both the spatiotemporal control afforded by optical control as well as the impressive array of transformations that are driven by the highly reactive intermediates generated upon excitation. This minireview discusses recent advances in the development of photochemical reactions for use in complex mixtures and highlights key considerations for future photochemical reaction designs.
Funding source: NIGMS funded Sensory Biology COBRE http://dx.doi.org./10.13039/100000057
Award Identifier / Grant number: P20 GM121310
Acknowledgments
We thank the NIGMS-funded Wyoming Sensory Biology COBRE program (P20 GM121310) for support.
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Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Research funding: This review was supported by NIGMS funded Sensory Biology COBRE program (P20 GM121310).
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Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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