An efficient, facile microwave-assisted synthesis has been developed for the preparation of unsymmetrical sulfide derivatives from 3-mercaptopropionic acid and a wide variety of alkyl, allyl or aryl chlorides or bromides. The synthesis performed in ethanol at 80 or 120 °C using sodium hydroxide as a base, selectively without an offensive smell, generates 3-(alkylthio)propionic acids in good yields. Effects of reaction components, temperature, and the heating technique on the formation of the product and side-products were studied.
Keywords: Thio-alkylation; Microwave-assisted Synthesis; Unsymmetrical Sulfide; β -(Alkylthio)carboxylic Acid
Received: 2007-3-3
Published Online: 2014-6-2
Published in Print: 2007-10-1
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