Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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An In Vitro Study on the Activity of Abelmoschus manihot L. Flower Extract on Skin Anti-wrinkle and Skin Whitening

금화규(Abelmoschus manihot ) 꽃 추출물의 In Vitro 피부 미백 및 주름 개선 효능 연구

  • 권현지 (대구한의대학교 일반대학원 화장품약리학과) ;
  • 범석현 (대구한의대학교 일반대학원 화장품약리학과) ;
  • 현진아 (대구한의대학교 일반대학원 화장품약리학과) ;
  • 강은빈 (대구한의대학교 일반대학원 화장품약리학과) ;
  • 박하은 (대구한의대학교 일반대학원 화장품약리학과) ;
  • 한동근 (대구한의대학교 일반대학원 화장품약리학과) ;
  • 김현정 ((주)허니스트) ;
  • 최은영 (대구한의대학교 화장품약리학과) ;
  • 안봉전 (대구한의대학교 화장품약리학과)
  • Received : 2021.12.22
  • Accepted : 2021.12.28
  • Published : 2021.12.30
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Abstract

In this study, the skin whitening and anti-wrinkle activity of Abelmoschus manihot (A. manihot) flowers were evaluated as a cosmetic material. A. manihot flowers were extracted using water and 70% ethanol. Tyrosinase inhibitory activity was evaluated to increase concentration-dependent inhibitory activity in both water (AMW) and 70% ethanol extracts (AME), and was found to inhibit melanin biosynthesis at concentrations that did not affect survival in B16F10 cell lines at 10, 25, 50, 75, and 100 ㎍/mL. As a result of measuring the anti-wrinkle effectiveness of A. manihot flowers, 70% ethanol extract (AME) showed higher anti-wrinkle activity than water extract (AMW). Through the results of this study, it is considered that the A. manihot flower extract can be used as a functional cosmetic material with whitening and anti-wrinkle activity.

본 연구는 화장품 소재로서 금화규(Abelmoschus manihot) 꽃의 미백 활성율 및 항주름 활성을 평가하기 위해 수행하였다. 금화규 꽃은 물과 70% 에탄올을 이용하여 추출하였다. Tyrosinase 억제 활성은 물과 70% 에탄올 추출물 모두 농도 의존적으로 억제 활성이 증가 된다고 평가되었으며, B16F10 세포주에서 생존율에 영향을 미치지 않은 농도인 10, 25, 50, 75, 100 ㎍/mL에서 멜라닌 생합성을 저해하는 것으로 확인되었다. 금화규 꽃의 항주름 효능으로는 collagenase와 elastase의 활성 저해 능력을 측정한 결과 70% 에탄올 추출물이 물 추출물보다 높은 항주름 활성을 보였다. 본 연구 결과를 통하여 금화규 꽃 추출물은 미백 활성과 항주름 활성을 가지는 기능성 화장품 소재로 사용 가능할 것으로 사료된다.

Keywords

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