Influence on Blood Pressure of Renal Isografts between Spontaneously Hypertensive and Normotensive Rats, Utilizing the F1 Hybrids

Kazuki KAWABE; Takushi X. WATANABE; Kumiko SHIONO; Hirofumi SOKABE

doi:10.1536/ihj.19.886

Influence on Blood Pressure of Renal Isografts between Spontaneously Hypertensive and Normotensive Rats, Utilizing the F₁ Hybrids

Kazuki KAWABE, Takushi X. WATANABE, Kumiko SHIONO, Hirofumi SOKABE

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Keywords: Renal transplantation, Plasma renin activity, Kidney renin activity, Denervation of the kidney

JOURNAL FREE ACCESS

1978 Volume 19 Issue 6 Pages 886-894

DOI https://doi.org/10.1536/ihj.19.886

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Abstract

The F₁ hybrids (F₁ ) of spontaneously hypertensive rats (SHR) and Wistar rats (W), whose kidneys were transplanted from SHR at the age of 10 weeks and 20 weeks, showed significant elevation of blood pressure (BP) for 11 weeks after the transplantation. In F₁ with W or F₁ kidneys BP was decreased near to the normal level. F₁ whose kidneys were transplanted from SHR or W showed low renin activity both in plasma and the kidney. It is suggested that BP of SHR is probably determined by the renal pro-hypertensive factor(s) other than renin influencing on sympathetic nerves through central nervous systems.

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