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Biomimetic apatite formation on poly(lactic acid) composites containing calcium carbonates

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Abstract

Poly(lactic acid) composites containing a mixture of calcium carbonates (vaterite, aragonite, and calcite) were prepared by a carbonation process in methanol. Soaking of the composites for 3 h in simulated body fluid (SBF) at 37 °C resulted in the deposition of bonelike apatite particles on the composite surface. After soaking the composites, vaterite phase in the composites was forward to dissolve rapidly, resulting in increase the supersaturation of the apatite in SBF. 13C cross-polarization magic angle spinning nuclear magnetic resonance (13C CP/MAS-NMR) spectra of the composites suggested the formation of a bond between Ca2+ ion and the COO- group, which induces the apatite nucleation. These results may elucidate the mechanism of means to reduce the induction period for apatite formation.

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Authors and Affiliations

  1. Department of Materials Science and Engineering, Nagoya Institute of Technology, 466-8555, Gokiso-cho, Showa-ku, Nagoya, Japan

    Hirotaka Maeda, Toshihiro Kasuga & Masayuki Nogami

  2. Department of Tissue Engineering, Nagoya University School of Medicine, 466-8550, Turumai-cho, Showa-ku, Nagoya, Japan

    Yoshitaka Hibino & Ken-Ichiro Hata

  3. Nagoya University Graduate School of Medicine, Department of Oral and Maxillofacial Surgery, 466-8550, Turumai-cho, Showa-ku, Nagoya, Japan

    Minoru Ueda

  4. Yabashi Industries Co. Ltd., 503-2213, Akasaka-cho, Ogaki, Japan

    Yoshio Ota

Authors
  1. Hirotaka Maeda
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  2. Toshihiro Kasuga
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  3. Masayuki Nogami
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  4. Yoshitaka Hibino
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  5. Ken-Ichiro Hata
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  6. Minoru Ueda
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  7. Yoshio Ota
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Correspondence to Hirotaka Maeda.

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Maeda, H., Kasuga, T., Nogami, M. et al. Biomimetic apatite formation on poly(lactic acid) composites containing calcium carbonates. Journal of Materials Research 17, 727–730 (2002). https://doi.org/10.1557/JMR.2002.0104

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  • DOI: https://doi.org/10.1557/JMR.2002.0104

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