Skip to main content
SpringerLink
Log in

Development of Novel Biodegradable Amino Acid Ester Based Polyphosphazene–Hydroxyapatite Composites for Bone Tissue Engineering

  • Published:
MRS Online Proceedings Library Aims and scope

Abstract

Hydroxyapatite formed from low temperature setting calcium phosphate cements (CPC) are currently been used for various orthopaedic applications. CPCs are attractive candidates for the development of scaffolds for bone tissue engineering, since they are moldable, resorbable, set at physiological temperature without the use of toxic chemicals, and can be processed in an operating room setting. However they may have mechanical disadvantages which seriously limit them to non-load bearing orthopaedic applications. The aim of the present study was to develop composites from polyphosphazenes and calcium deficient hydroxyapatite precursors to form poorly crystalline hydroxyapatite-polymer composites. Composites were formed from calcium deficient hydroxyapatite precursors (Ca/P–1.5, 1.6) and biodegradable polyphosphazenes, poly[bis(ethyl alanato)phosphazene] (PNEA) and poly[(50%ethyl alanato) (50%methyl phenoxy)phosphazene] (PNEA50mPh50) at physiological temperature. The results demonstrated that poorly crystalline hydroxyapatite that resembled the mineral component of bone was formed in the presence of biodegradable polyphosphazenes. The surface morphology of all the four composites was identical with a porous microstructure. The composites supported the adhesion and proliferation of osteoblast like MC3T3-E1 cells making them potential candidates for bone tissue engineering.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J. O. Hollinger, and G. C. Battistone, Clin. Orthop. 207, 290 (1986).

    CAS  Google Scholar 

  2. M. Jarcho, Clin. Orthop. 157, 259 (1981).

    CAS  Google Scholar 

  3. W. E. Brown, and L. C. Chow, “Dental restorative cement pastes,” US patent no. 4,518,430 (1985).

  4. R. A. Mickiewicz, A. M. Mayes, and D. Knaack, J. Biomed. Mater. Res. 61, 581 (2002).

    Article  CAS  Google Scholar 

  5. K. Miyazaki, T. Horibe, J. M. Antonucci, S. Takagi, and L. C. Chow, Dent. Mater. 9, 41 (1993).

    Article  CAS  Google Scholar 

  6. K. Miyazaki, T. Horibe, J. M. Antonucci, S. Takagi, and L. C. Chow, Dent. Mater. 9, 46 (1993).

    Article  CAS  Google Scholar 

  7. C. Durucan, and P. W. Brown, J. Biomed. Mater. Res. 51, 726 (2000).

    Article  CAS  Google Scholar 

  8. C. Durucan, and P. W. Brown, J. Biomed. Mater. Res. 51, 717 (2000).

    Article  CAS  Google Scholar 

  9. H. R. Allcock in Chemistry and Application of Polyphosphazenes, edited by H. R. Allcock, (John Wiley & Sons, 2003).

  10. R. Murugan, and S. Ramakrishna, Biomaterials, 25, 3829 (2004).

    Article  CAS  Google Scholar 

Download references

Acknowledgement

The authors acknowledge the financial support from NIH grant #AR46560. Dr. Cato T. Laurencin was previously the recipient of a Presidential Faculty Fellow Award from the National Science Foundation.

Author information

Authors and Affiliations

  1. Department of Chemical Engineering, University of Virginia, Charlottesville, VA, USA

    Swaminathan Sethuraman & Cato T. Laurencin M.D., Ph.D. (University Professor, Lillian T. Pratt Distinguished Professor and Chairman of Orthopaedic Surgery Professor of Biomedical Engineering, Professor of Chemical Engineering)

  2. Department of Orthopaedic Surgery, University of Virginia, Charlottesville, VA, USA

    Lakshmi S. Nair & Cato T. Laurencin M.D., Ph.D. (University Professor, Lillian T. Pratt Distinguished Professor and Chairman of Orthopaedic Surgery Professor of Biomedical Engineering, Professor of Chemical Engineering)

  3. Department of Chemistry, Pennsylvania State University, University Park, PA, USA

    Anurima Singh, Jared D. Bender & Harry R. Allcock

  4. Intercollege Materials Research Laboratory, Pennsylvania State University, University Park, PA, USA

    Yaser E. Greish & Paul W. Brown

  5. Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA

    Cato T. Laurencin M.D., Ph.D. (University Professor, Lillian T. Pratt Distinguished Professor and Chairman of Orthopaedic Surgery Professor of Biomedical Engineering, Professor of Chemical Engineering)

Authors
  1. Swaminathan Sethuraman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lakshmi S. Nair
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Anurima Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jared D. Bender
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yaser E. Greish
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Paul W. Brown
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Harry R. Allcock
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Cato T. Laurencin M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Cato T. Laurencin M.D., Ph.D..

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sethuraman, S., Nair, L.S., Singh, A. et al. Development of Novel Biodegradable Amino Acid Ester Based Polyphosphazene–Hydroxyapatite Composites for Bone Tissue Engineering. MRS Online Proceedings Library 845, 151–156 (2004). https://doi.org/10.1557/PROC-845-AA5.22

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1557/PROC-845-AA5.22

Keywords

Search

Navigation