Skip to main content
SpringerLink
Log in

Piezo- and Magnetoelectric Polymers as Biomaterials for Novel Tissue Engineering Strategies

  • Published:
MRS Advances Aims and scope Submit manuscript

Abstract

Tissue engineering and regenerative medicine are increasingly taking advantage of active materials, allowing to provide specific clues to the cells. In particular, the use of electroactive polymers that deliver an electrical signal to the cells upon mechanical solicitation, open new scientific and technological opportunities, as they in fact mimic signals and effects that occur in living tissues, allowing the development of suitable microenvironments for tissue regeneration. Thus, a novel overall strategy for bone and muscle tissue engineering was developed based on the fact that these cells type are subjected to mechano-electrical stimuli in their in vivo microenvironment and that piezo- and magnetoelectric polymers, used as scaffolds, are suitable for delivering those cues. The processing and functional characterizations of piezoelectric and magnetoelectric polymers based on poly(vinylindene fluoride) and poly-L-lactic acid in a variety of shapes, from microspheres to electrospun mats and three dimensional scaffolds, are shown as well as their performance in the development of novel bone and muscle tissue engineering.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. C. Ribeiro, V. Sencadas, D. M. Correia and S. Lanceros-Méndez, Colloids Surf B 136, 46–55 (2015).

    Article  CAS  Google Scholar 

  2. M. Mehta, K. Schmidt-Bleek, G. N. Duda and D. J. Mooney, Adv Drug Deliv Rev 64 (12), 1257–1276 (2012).

    Article  CAS  Google Scholar 

  3. P. Martins and S. Lanceros-Méndez, Adva Funct Mater 23 (27), 3371–3385 (2013).

    Article  CAS  Google Scholar 

  4. D. M. Correia, R. Golcalves, C. Ribeiro, V. Sencadas, G. L. Botelho, J. L. Gomez-Ribelles and s. lanceros-mendez, RSC Adv 4, 33013–33021 (2014).

  5. D. M. Correia, V. Sencadas, C. Ribeiro, P. M. Martins, P. Martins, F. M. Gama, G. Botelho and S. Lanceros-Méndez, J Colloid Interf Sci 476, 79–86 (2016).

    Article  CAS  Google Scholar 

  6. V. Sencadas, R. Gregorio and S. Lanceros-Méndez, J Macromolec Sci B 48 (3), 514–525 (2009).

    Article  CAS  Google Scholar 

  7. S. J. Hong, H. S. Yu and H. W. Kim, Acta Biomaterialia 5 (5), 1725–1731 (2009).

    Article  CAS  Google Scholar 

  8. V. Sencadas, S. Lanceros-Méndez and J. F. Mano, Thermochimica Acta 424 (1–2), 201–207 (2004).

  9. Z. H. Liu, C. T. Pan, L. W. Lin and H. W. Lai, Sens Actuat A 193 (0), 13–24 (2013).

    Article  CAS  Google Scholar 

  10. H. Na, X. Liu, J. Li, Y. Zhao, C. Zhao and X. Yuan, Polymer 50 (26), 6340–6349 (2009).

    Article  CAS  Google Scholar 

  11. C. Ribeiro, V. Sencadas, J. L. G. Ribelles and S. Lanceros-Méndez, Soft Mater 8 (3), 274–287 (2010).

    Article  CAS  Google Scholar 

  12. D. M. Correia, C. Ribeiro, V. Sencadas, L. Vikingsson, M. Oliver Gasch, J. L. Gómez Ribelles, G. Botelho and S. Lanceros-Méndez, Mater Design 92, 674–681 (2016).

    Article  CAS  Google Scholar 

  13. C. Ribeiro, V. Correia, P. Martins, F. M. Gama and S. Lanceros-Mendez, Colloids Surf B 140, 430–436 (2016).

    Article  CAS  Google Scholar 

  14. M. N. T.-M. R. Sobreiro-Almeida, E. O. Carvalho, L. Cordón, S. Doria, L. Senent, D. M. Correia, C. Ribeiro, S. Lanceros-Méndez, R. Sabater i Serra, J. L. Gomez Ribelles and A. Sempere, Intern J Molec Sci 18 (11), 2391 (2017).

  15. R. Gonçalves, P. Martins, D. M. Correia, V. Sencadas, J. L. Vilas, L. M. León, G. Botelho and S. Lanceros-Méndez, RSC Adv 5 (45), 35852–35857 (2015).

    Article  Google Scholar 

  16. M. Zamani, M. P. Prabhakaran and S. Ramakrishna, Int J Nanomedicine 8, 2997–3017 (2013).

    Google Scholar 

  17. D. M. Correia, V. Sencadas, C. Ribeiro, P. M. Martins, P. Martins, F. M. Gama, G. Botelho and S. Lanceros-Méndez, J Colloid Interf Sci 476 (Supplement C), 79–86 (2016).

  18. M. P. Prabhakaran, L. Ghasemi-Mobarakeh, G. R. Jin and S. Ramakrishna, J. Biosci. Bioeng. 112 (5), 501–507 (2011).

    Article  CAS  Google Scholar 

  19. C. Ribeiro, D. M. Correia, S. Ribeiro, V. Sencadas, G. Botelho and S. Lanceros-Méndez, Eng Life Sci 15 (4), 351–356 (2015).

    Article  CAS  Google Scholar 

  20. C. Ribeiro, V. Sencadas, C. M. Costa, J. L. Gómez Ribelles and S. Lanceros-Méndez, Sci Technol Adv Mater 12 (1) (2011).

  21. R. Gonçalves, P. Martins, X. Moya, M. Ghidini, V. Sencadas, G. Botelho, N. D. Mathur and S. Lanceros-Mendez, Nanoscale 7 (17), 8058–8061 (2015).

    Article  Google Scholar 

  22. J. Zheng, A. He, J. Li and C. C. Han, Macromolecular Rapid Commun 28 (22), 2159–2162 (2007).

    Article  CAS  Google Scholar 

  23. L. Budyanto, Y. Q. Goh and C. P. Ooi, J Mater Sci: Mater Medicine 20 (1), 105–111 (2009).

    CAS  Google Scholar 

  24. A. H. Rajabi, M. Jaffe and T. L. Arinzeh, Acta Biomater. 24, 12–23 (2015).

    Article  CAS  Google Scholar 

  25. M. T. Rodrigues, M. E. Gomes, J. F. Mano and R. L. Reis, in Advanced Materials Forum Iv, edited by A. T. Marques, A. F. Silva, A. P. M. Baptista, C. Sa, F. Alves, L. F. Malheiros and M. Vieira (Trans Tech Publications Ltd, Stafa-Zurich, 2008), Vol. 587–588, pp. 72–76.

  26. J. Parssinen, H. Hammaren, R. Rahikainen, V. Sencadas, C. Ribeiro, S. Vanhatupa, S. Miettinen, S. Lanceros-Mendez and V. P. Hytonen, J. Biomed. Mater. Res. A 103 (3), 919–928 (2015).

    Article  Google Scholar 

  27. C. Ribeiro, J. Parssinen, V. Sencadas, V. Correia, S. Miettinen, V. P. Hytonen and S. Lanceros-Mendez, J. Biomed. Mater. Res. A 103 (6), 2172–2175 (2015).

    Article  CAS  Google Scholar 

  28. C. Ribeiro, S. Moreira, V. Correia, V. Sencadas, J. G. Rocha, F. M. Gama, J. L. G. Ribelles and S. Lanceros-Mendez, RSC Adv. 2 (30), 11504–11509 (2012).

    Article  CAS  Google Scholar 

  29. C. Ribeiro, D. M. Correia, I. Rodrigues, L. Guardao, S. Guimaraes, R. Soares and S. Lanceros-Mendez, Mater Letters 209, 118–121 (2017).

    Article  CAS  Google Scholar 

  30. A. Ignatius, H. Blessing, A. Liedert, C. Schmidt, C. Neidlinger-Wilke, D. Kaspar, B. Friemert and L. Claes, Biomaterials 26 (3), 311–318 (2005).

    Article  CAS  Google Scholar 

  31. R. F. Valentini, T. G. Vargo, J. A. Gardella and P. Aebischer, Biomaterials 13 (3), 183–190 (1992).

    Article  CAS  Google Scholar 

  32. H. F. Guo, Z. S. Li, S. W. Dong, W. J. Chen, L. Deng, Y. F. Wang and D. J. Ying, Colloids Surf B 96, 29–36 (2012).

    Article  CAS  Google Scholar 

  33. P. M. Martins, S. Ribeiro, C. Ribeiro, V. Sencadas, A. C. Gomes, F. M. Gama and S. Lanceros-Méndez, RSC Adv 3 (39), 17938–17944 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centro de Física, Universidade do Minho, Campus de Gualtar, Braga, 4710-058, Portugal

    C. Ribeiro, S. Ribeiro & M. M. Fernandes

  2. CEB - Centre of Biological Engineering, University of Minho, Campus de Gualtar, Braga, 4710-057, Portugal

    C. Ribeiro & M. M. Fernandes

  3. Department of chemistry and CQ-VR, University of Trás-os-Montes e Alto Douro, Vila Real, 5000-801, Portugal

    D. M. Correia

  4. BCMaterials, Parque Científico y Tecnológico de Bizkaia, Derio, 48160, Spain

    D. M. Correia & S. Lanceros-Mendez

  5. Centre of Molecular and Environmental Biology (CBMA), Universidade do Minho, Campus de Gualtar, Braga, 4710-057, Portugal

    S. Ribeiro

  6. IKERBASQUE, Basque Foundation for Science, Bilbao, 48013, Spain

    S. Lanceros-Mendez

Authors
  1. C. Ribeiro
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. M. Correia
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Ribeiro
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. M. Fernandes
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. Lanceros-Mendez
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. Lanceros-Mendez.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ribeiro, C., Correia, D.M., Ribeiro, S. et al. Piezo- and Magnetoelectric Polymers as Biomaterials for Novel Tissue Engineering Strategies. MRS Advances 3, 1671–1676 (2018). https://doi.org/10.1557/adv.2018.223

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1557/adv.2018.223

Search

Navigation