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Nanotexturization of Ti-based implants in simulated body fluid: Influence of synthesis parameters on coating properties and kinetics of drug release

  • Biomedical Materials, Regenerative Medicine and Drug Delivery
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Abstract

In the present study, TiO2NT coatings grown on simulated body fluid-based electrolyte were investigated as drug delivery devices. Nanotubes (NTs) were grown over commercially pure Ti and Ti6Al4V alloy. Morphology analysis showed that NTs in alloy samples present an inner diameter of 10 nm smaller in average than NTs grown over pure Ti. The surface wettability in water decreased with the anodizing time for both substrates. The application of coatings as drug delivery devices has been studied through the incorporation of ciprofloxacin. To control the drug release, collagen was used as the diffusional barrier. It was observed the drug release follows a Fick’s kinetics. Bioactivity assays showed the absence of hemolytic activity. The concentration of the drug during the release interval remained below the toxic concentration limit, presenting a bacteriostatic activity. All coatings prepared presented a high antibacterial activity, being the area of inhibition of bacterial growth above 13 times the area of the implant.

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Acknowledgment

The authors thank the UTFPR, Central Analysis of UTFPR-PB, UFSCar, Biocenter Clinical Analysis Laboratory, and to Brazilian Nanotechnology National Laboratory (LNNano) in National Center of Energy and Materials Research (CNPEM) and Analysis Center of UTFPR-PB. This work was supported by UTFPR [PAPCDT 06/2016 and 07/2017]. This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001.

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Authors and Affiliations

  1. Department of Chemistry, Federal Technological University of Paraná (UTFPR), Pato Branco, PR, 85503-390, Brazil

    Carlise Hannel Ferreira, Anna Paulla Simon, Vidiany Aparecida Queiroz Santos, Patrícia Teixeira Marques & Mariana de Souza Sikora

  2. Department of Physics, Chemistry and Mathematics, UFSCar, Sorocaba, SP, 18052-780, Brazil

    Andressa Rodrigues, Janaina Soares Santos & Francisco Trivinho-Strixino

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  1. Carlise Hannel Ferreira
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Correspondence to Mariana de Souza Sikora.

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Ferreira, C.H., Simon, A.P., Santos, V.A.Q. et al. Nanotexturization of Ti-based implants in simulated body fluid: Influence of synthesis parameters on coating properties and kinetics of drug release. Journal of Materials Research 34, 2828–2836 (2019). https://doi.org/10.1557/jmr.2019.216

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  • DOI: https://doi.org/10.1557/jmr.2019.216

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