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Light-triggered modulation of cell antioxidant defense by polymer semiconducting nanoparticles in a model organism

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Abstract

Photovoltaic organic semiconductors are emerging in many therapeutic applications, including drug delivery and optical control of cell function. However, for their safe use the possible concomitant elicitation of undesired responses in target cells need to be carefully evaluated. Here we describe molecular responses activated by semiconducting polymer nanoparticles based on poly(3-hexyl)thiophene (P3HT) in the model Hydra vulgaris, previously shown to respond to P3HT-NP photostimulation and showed a decrease in the total antioxidant capacity and an increase in the DNA and protein oxidation levels, paving the way to a novel use of photovoltaic devices to control intracellular redox equilibrium.

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Acknowledgment

Technical assistance of Giuseppe Marino and Ilaria Panico (ISASI-CNR, Pozzuoli) for animal culturing is gratefully acknowledged. We also thank for technical assistance in animal irradiation using white light LED source Dr. Massimo Rippa (ISASI-CNR, Pozzuoli). MM acknowledges the European Union’s Horizon 2020 research and innovation programme (Marie Skiodowska-Curie grant agreement No. 660228).

Author information

Author notes

  1. Maria Moros

    Present address: Present address: Instituto de Ciencia de Materiales de Aragón, C/Mariano Esquillor s/n, 50018, Zaragoza, Spain

Authors and Affiliations

  1. Istituto di Scienze Applicate e Sistemi Intelligenti “E. Caianiello”, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078, Pozzuoli, Italy

    Maria Moros, Giada Onorato, Martina Blasio, Angela Tino & Claudia Tortiglione

  2. Department of Cell Biochemistry, Faculty of Biotechnology, University of Rzeszow, Pigonia 1, 35-310, Rzeszow, Poland

    Anna Lewinska

  3. Center for Nano Science and Technology @PoliMi, Istituto Italiano di Tecnologia, Via Pascoli 70/3, 20133, Milano, Italy

    Maria Rosa Antognazza & Guglielmo Lanzani

  4. Istituto per la Sintesi Organica e la Fotoreattivita’, Consiglio Nazionale delle Ricerche, Via P. Gobetti 101, 40129, Bologna, Italy

    Maria Di Francesca

  5. Department of Physics, Politecnico di Mila, P.zza L. da Vinci 32, 20133, Milano, Italy

    Guglielmo Lanzani

  6. Department of Genetics, Faculty of Biotechnology, University of Rzeszow, Pigonia 1, 35-310, Rzeszow, Poland

    Maciej Wnuk

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  1. Maria Moros
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  2. Anna Lewinska
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Corresponding author

Correspondence to Claudia Tortiglione.

Additional information

These authors contributed equally to this work.

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The supplementary material for this article can be found at {rs|https://doi.org/10.1557/mrc.2018.104|url|}.

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Moros, M., Lewinska, A., Onorato, G. et al. Light-triggered modulation of cell antioxidant defense by polymer semiconducting nanoparticles in a model organism. MRS Communications 8, 918–925 (2018). https://doi.org/10.1557/mrc.2018.104

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  • DOI: https://doi.org/10.1557/mrc.2018.104

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