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Graphene-based materials for biosensing and bioimaging

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Abstract

Graphene, a free-standing two-dimensional crystal with one-atom thickness, exhibits distinct properties that are highly attractive for biosensing and bioimaging, such as a high electrical conductivity, a large planar area, and an excellent ability to quench fluorescence. This article selectively reviews recent advances in the field of graphene-based materials for biosensing and bioimaging. In particular, graphene-based enzyme biosensors, DNA biosensors, and immunosensors are summarized in detail. Graphene-based biotechnology for cell imaging is also described. Future perspectives and possible challenges in this rapidly developing area are also discussed.

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References

  1. Y. Wang, Z. Li, J. Wang, J. Li, Y. Lin, Trends Biotechnol. 29, 205 (2011).

    Google Scholar 

  2. Y. Sun, Q. Wu, G. Shi, Energy Environ. Sci. 4, 1113 (2011).

  3. J. Wu, W. Pisula, K. Mullen, Chem. Rev. 107, 718 (2007).

  4. S. Park, R.S. Ruoff, Nat. Nanotechnol. 4, 217 (2009).

  5. X. Fan, W. Peng, Y. Li, X. Li, S. Wang, G. Zhang, F. Zhang, Adv. Mater. 20, 4490 (2008).

  6. X. Du, I. Skachko, A. Barker, E.Y. Andrei, Nat. Nanotechnol. 3, 491 (2008).

  7. M.D. Stoller, S. Park, Y. Zhu, J. An, R.S. Ruoff, Nano Lett. 8, 3498 (2008).

  8. H. Chang, L. Tang, Y. Wang, J. Jiang, J. Li, Anal. Chem. 82, 2341 (2010).

  9. Z. Tang, H. Wu, J.R. Cort, G.W. Buchko, Y. Zhang, Y. Shao, I.A. Aksay, J. Liu, Y. Lin, Small 6, 1205 (2010).

  10. S. Yang, W.Z. Jia, Q.Y. Qian, Y.G. Zhou, X.H. Xia, Anal. Chem. 81, 3478 (2009).

  11. J.J. Gooding, Electroanalysis 20, 573 (2008).

  12. F. Patolsky, G. Zheng, C.M. Lieber, Anal. Chem. 78, 4260 (2006).

  13. J. Tang, D. Tang, R. Niessner, G. Chen, D. Knopp, Anal. Chem. 83, 5407 (2011).

  14. M. Strömberg, T. Zardán Gómez de la Torre, J. Göransson, K. Gunnarson, M. Nilsson, P. Svedlindh, M. Stromme, Anal. Chem. 81, 3398 (2009).

  15. J. Wang, Small 1, 1036 (2005).

  16. Y. Shao, J. Wang, H. Wu, J. Liu, I.A. Aksay, Y. Lin, Electroanalysis 22, 1027 (2010).

  17. K.R. Ratinac, W. Yang, J.J. Gooding, P. Thordarson, F. Brael, Electroanalysis 23, 803 (2011).

  18. Y. Wang, S. Zhang, D. Du, Y. Shao, Z. Li, J. Wang, M.H. Engelhard, J. Li, Y. Lin, J. Mater. Chem. 21, 5319 (2011).

  19. J. Zhang, F. Zhang, H. Yang, X. Huang, H. Liu, J. Zhang, S. Guo, Langmuir 26, 6083 (2010).

  20. M. Pumera, R. Scipioni, H. Iwai, T. Ohno, Y. Miyahara, M. Boero, Chem. Eur. J. 15, 10851 (2009).

  21. X. Kang, J. Wang, H. Wu, I.A. Aksay, J. Liu, Y. Lin, Biosens. Bioelectron. 25, 901 (2009).

  22. W. Yang, K.R. Ratinac, S.P. Ringer, P. Thordarson, J.J. Gooding, F. Braet, Angew. Chem., Int. Ed. 49, 2114 (2010).

  23. C. Shan, H. Yang, J. Song, D. Han, A. Ivaska, L. Niu, Anal. Chem. 81, 2378 (2009).

  24. Y. Wang, Y. Shao, D.W. Matson, J. Li, Y. Lin, ACS Nano 4, 1790 (2010).

  25. L.A.L. Tang, J. Wang, K.P. Loh, J. Am. Chem. Soc. 132, 10976 (2010).

  26. L. Feng, S. Zhang, Z. Liu, Nanoscale 3, 1252 (2011).

  27. Z. Luo, P.M. Vora, E.J. Mele, A.T.C. Johnson, J.M. Kikkawa, Appl. Phys. Lett. 94, 111909 (2009).

  28. K.P. Loh, Q. Bao, G. Eda, M. Chhowalla, Nat. Chem. 2, 1015 (2010).

  29. F. Liu, J.Y. Choi, T.S. Seo, Biosens. Bioelectron. 25, 2361 (2010).

  30. C.H. Lu, H.H. Yang, C.L. Zhu, X. Chen, G.N. Chen, Angew. Chem., Int. Ed. 48, 4785 (2009).

  31. S. He, B. Song, D. Li, C. Zhu, W. Qi, Y. Wen, L. Wang, S. Song, H. Fang, C. Fan, Adv. Funct. Mater. 20, 453 (2010).

  32. M. Wu, R. Kempaiah, P.J.J. Huang, V. Maheshwari, J. Liu, Langmuir 27, 2731 (2011).

  33. X.H. Zhao, R.M. Kong, X.B. Zhang, H.M. Meng, W.N. Liu, W. Tan, G.L. Shen, R.Q. Yu, Anal. Chem. 83, 5062 (2011).

  34. X. Wu, H. Liu, J. Liu, K.N. Haley, J.A. Treadway, J.P. Larson, N. Ge, F. Peale, M.P. Bruchez, Nat. Biotechnol. 21, 41 (2002).

  35. H. Dong, W. Gao, F. Yan, H. Ji, H. Ju, Anal. Chem. 82, 5511 (2010).

  36. M. Zhou, Y. Zhai, S. Dong. Anal. Chem. 81, 5603 (2009).

  37. C.E. Banks, T.J. Davies, G.G. Wildgoose, R.G. Compton, Chem. Commun. 829, (2005).

  38. C.X. Lim, H.Y. Hoh, P.K. Ang, K.P. Loh, Anal. Chem. 82, 7387 (2010).

  39. M. Muti, S. Sharma, A. Erdem, P. Papakonstantinou, Electroanalysis 23, 272 (2011).

  40. A. Bonanni, M. Pumera. ACS Nano 5, 2356 (2011).

  41. Z. Wang, J. Zhang, P. Chen, X. Zhou, Y. Yang, S.N. Wu, L. Niu, Y. Han, L. Wang, P. Chen, F. Boey, Q. Zhanga, B. Liedberg, H. Zhang, Biosens. Bioelectron. 26, 3881 (2011).

  42. Y. Hu, F. Li, X. Bai, D. Li, S. Hua, K. Wang, L. Niu, Chem. Commun. 47, 1743 (2011).

  43. D. Du, L. Wang, Y. Shao, J. Wang, M.H. Engelhard, Y. Lin, Anal. Chem. 83, 746 (2011).

  44. Y. Wan, Y. Wang, J. Wu, D. Zhang, Anal. Chem. 83, 648 (2011).

  45. J. Tang, D. Tang, R. Niessner, G. Chen, D. Knopp, Anal. Chem. 83, 5407 (2011).

  46. Q. Wei, X. Xin, B. Du, D. Wu, Y. Han, Y. Zhao, Y. Cai, R. Li, M. Yang, H. Li, Biosens. Bioelectron. 26, 723 (2010).

  47. M. Yang, A. Javadi, H. Li, S. Gong, Biosens. Bioelectron. 26, 560 (2010).

  48. D. Du, Z. Zou, Y. Shin, J. Wang, H. Wu, M.H. Engelhard, J. Liu, I.A. Aksay, Y. Lin, Anal. Chem. 82, 2989 (2010).

  49. K. Liu, J.J. Zhang, C. Wang, J.J. Zhu, Biosens. Bioelectron. 26, 3627 (2011).

  50. J.H. Jung, D.S. Cheon, F. Liu, K.B. Lee, T.S. Seo, Angew. Chem., Int. Ed. 49, 5708 (2010).

  51. Y. Wang, Z. Li, D. Hu, C.T. Lin, J. Li, Y. Lin, J. Am. Chem. Soc. 132, 9274 (2010).

  52. M.L. Mueller, X. Yan, J.A. McGuire, L.S. Li, Nano Lett. 10, 2679 (2010).

  53. L.A. Ponomarenko, F. Schedin, M.I. Katsnelson, R. Yang, E.W. Hill, K.S. Novoselov, A.K. Geim, Science 320, 356 (2008).

  54. D. Pan, J. Zhang, Z. Li, M. Wu, Adv. Mater. 22, 734 (2010).

  55. J. Shen, Y. Zhu, C. Chen, X. Yang, C. Li, Chem. Commun. 47, 2580 (2011).

  56. S. Zhu, J. Zhang, C. Qiao, S. Tang, Y. Li, W. Yuan, B. Li, L. Tian, F. Liu, R. Hu, H. Gao, H. Wei, H. Zhang, H. Sun, B. Yang, Chem. Commun. 47, 6858 (2011).

  57. W. Chen, P. Yi, Y. Zhang, L. Zhang, Z. Deng, Z. Zhang, ACS Appl. Mater. Interfaces 3, 4085 (2011).

    Google Scholar 

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Authors and Affiliations

  1. College of Chemistry, Central China Normal University, China

    Dan Du & Yuqi Yang

  2. Pacific Northwest National Laboratory, United States

    Yuehe Lin

Authors
  1. Dan Du
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  2. Yuqi Yang
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  3. Yuehe Lin
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Correspondence to Dan Du.

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Du, D., Yang, Y. & Lin, Y. Graphene-based materials for biosensing and bioimaging. MRS Bulletin 37, 1290–1296 (2012). https://doi.org/10.1557/mrs.2012.209

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