In this paper, we propose multiple-supply-voltages aware high-level synthesis algorithm for HDR architectures which realizes high-speed and high-efficient circuits. We propose three new techniques: virtual area estimation, virtual area adaptation, and floor-planning-directed huddling, and integrate them into our HDR architecture synthesis algorithm. Virtual area estimation/adaptation effectively estimates a huddle area by gradually reducing it during iterations, which improves the convergence of our algorithm. Floorplanning-directed huddling determines huddle composition very effectively by performing floorplanning and functional unit assignment inside huddles simultaneously. Experimental results show that our algorithm achieves about 29% run-time-saving compared with the conventional algorithms, and obtains a solution which cannot be obtained by our original algorithm even if a very tight clock constraint is given.