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European Journal of Dermatology

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Cutaneous necrosis induced by extravasation of hydroxyzine Volume 24, numéro 1, January-February 2014

Illustrations


  • Figure 1
Auteurs
Department of Dermatology,
Gunma University Graduate School of Medicine,
3-39-22 Showa-machi, Maebashi,
Gunma 371-8511, Japan

Hydroxyzine is a first-generation antihistamine agent. It is clinically used as a mild tranquillizer as well as an antihistamine. It is widely administered to many patients, intravenously or intramuscularly, as a pre-anesthetic medication, sedative or antipruritic agent [1]. Adverse events caused by hydroxyzine are rare and include drowsiness, dry mouth, local pain, etc. [2]. When intramuscularly-given hydroxyzine leaks into intradermal and/or subcutaneous tissue, the skin structure is damaged. Therefore, [...]