An axial chirality and disorder of positional isomers in a crystal of highly cytotoxic 3-acetyl-1,3-bis(2-chloro-4-nitrophenyl)-1E-triazene

Authors

  • Krešimir Molčanov
  • Slovenko Polanc
  • Maja Osmak
  • Biserka Kojić-Prodić

DOI:

https://doi.org/10.17344/acsi.2015.1420

Keywords:

axial chirality, enantiomeric disorder, molecular structure, crystal structure

Abstract

Biologically active 4-nitro-substituted 1,3-diaryltriazene, a chemical analogue of 1,3-bis(4'-amidinophenyl)-triazene-berenil®, belongs to the novel, chemically modified class of potent antitumor agents. Its structural characterization by X-ray analysis and 1H NMR spectroscopy is performed to determine molecular overall conformation in view of its possible interaction to DNA   

Author Biographies

Krešimir Molčanov, Rudjer Bošković Institute


   

Slovenko Polanc, Faculty of Chemistry and Chemical Technology, University of Ljubljana


   

Maja Osmak, Rudjer Bošković Institute


   

Biserka Kojić-Prodić, Rudjer Bošković Institute


   

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Published

29.04.2015

Issue

Vol. 62 No. 2 (2015)

Section

Organic chemistry

License

Except where otherwise noted, articles in this journal are published under the Creative Commons Attribution 4.0 International License