The effect of taurine on state of experimental gestosis in rats

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Abstract

BACKGROUND: Gestosis (preeclampsia) is an important problem of modern obstetrics. Despite the improvement of methods of prevention and treatment, there is an increase in the rate of this pregnancy complication. In this regard, the search for new approaches to the treatment of preeclampsia is an important problem of modern perinatology.

AIM: The aim of this study is studying of the effect of taurine on experimental gestosis in rats.

MATERIALS AND METHODS: Preeclampsia was induced on female rats by sodium nitrite and lipopolysaccharide. 2-aminoethanesulfonic acid was administered at a dose of 44.3 mg / kg (in terms of taurine) from the 16th to the 19th day of pregnancy. The number of implantation sites, resorption sites, live fetuses, weight of placentas and fetuses, lactate dehydrogenase activity, content of lactic and pyruvic acids, nitric oxide, malondialdehyde and creatine were evaluated.

RESULTS: It has been shown that 2-aminoethanesulfonic acid leads to normalization of the metabolic processes (the level of malondialdehyde, nitric oxide, lactate and lactate dehydrogenase activity) in the body of pregnant female rats with induced preeclampsia in the last trimester of pregnancy. Taurine reduced the quantity of resorption, increased the weight of placentas and fetuses. Along with a correction of the lactate level, pyruvate and lactate dehydrogenase activity, it was observed a decrease of creatine level in placentas.

CONCLUSIONS: Obtained results allows us to recommend taurine, which has antioxidant, antihypoxic, membrane stabilizing, detoxifying, osmoregulating and diuretic effects, for the treatment of placental disorders with preeclampsia.

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About the authors

Tatiana N. Savanteeva-Lyubimova

Smorodintsev Research Institute of Influenza

Email: drugs_safety@mail.ru
ORCID iD: 0000-0003-4516-3308
SPIN-code: 3543-6799

MD, Dr. Sci (Med.), Professor, leading research associate of the laboratory of drug safety

Russian Federation, Saint Petersburg

Konstantin V. Sivak

Smorodintsev Research Institute of Influenza

Email: kvsivak@gmail.com
ORCID iD: 0000-0003-4064-5033
SPIN-code: 7426-8322

Cand. Sci. (Med.) head of Department of preclinical trials

Russian Federation, Saint Petersburg

Kira I. Stosman

Smorodintsev Research Institute of Influenza

Author for correspondence.
Email: labtox6@rambler.ru
ORCID iD: 0000-0001-7959-2376
SPIN-code: 8423-0170

Cand. Sci. (Med.), senior research associate of the laboratory of drug safety

Russian Federation, Saint Petersburg

Andrei G. Aleksandrov

Smorodintsev Research Institute of Influenza

Email: forphchemistry@gmail.com
ORCID iD: 0000-0001-9212-3865

Cand. Sci. (Med.), research associate of the laboratory of drug safety

Russian Federation, Saint Petersburg

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