Research Article
Year 2023,
Volume: 9 Issue: 6 - November 2023, 1350 - 1359, 04.11.2023
Abstract
References
- 1. Cuzick J. Radiotherapy for breast cancer. J Natl Cancer Inst 2005;97:406-7.
- 2. Overgaard M, Hansen PS, Overgaard J, Rose C, Andersson M, Bach F, et al. Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial. N Engl J Med 1997;337:949-55.
- 3. Ragaz J, Jackson SM, Le N, Plenderleith IH, Spinelli JJ, BascoVE, et al. Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer. N Engl J Med 1997;337:956-62.
- 4. Xiang X, Ding Z, Feng L, Li N. A meta-analysis of the efficacy and safety of accelerated partial breast irradiation versus whole-breast irradiation for early-stage breast cancer. Radiat Oncol 2021;16:24.
- 5. Polgár C, Kahán Z, Ivanov O, Chorváth M, Ligačová A, Csejtei A, et al. Radiotherapy of Breast Cancer-Professional Guideline 1st Central-Eastern European Professional Consensus Statement on Breast Cancer. Pathol Oncol Res 2022;28:1610378.
- 6. Whelan TJ, Julian J, Wright J, Jadad AR, Levine ML. Does locoregional radiation therapy improve survival in breast cancer? A meta-analysis. J Clin Oncol 2000;18:1220-9.
- 7. Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER,et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 2002;347:1233-41.
- 8. Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 2002;347:1227-32.
- 9. Haussmann J, Corradini S, Nestle-Kraemling C, Bölke E, Njanang FJD, Tamaskovics B, et al. Recent advances in radiotherapy of breast cancer. Radiat Oncol 2020;15:71.
- 10. Franjic S. Ultrasound in medicine. Am J Biomed Sci Res 2021;14:362-4.
- 11. Massone E, Orlandi D, Bellelli A, Martino F, Cavagnaro L, Formica M, et al. Real-time fusion-imaging in low back pain: a new navigation system for facet joint injections. Radiol Med 2018;123:851-9.
- 12. Rubin P, Constine LS, Fajardo LF, Phillips TL, Wasserman TH. RTOG Late Effects Working Group. Overview. Late Effects of Normal Tissues (LENT) scoring system. Int J Radiat Oncol Biol Phys 1995;31:1041-2.
- 13. Bentzen SM, Dische S. Morbidity related to axillary irradiation in the treatment of breast cancer. Acta Oncol 2000;39:337-47.
- 14. Lauridsen MC, Overgaard M, Overgaard J, Hessov IB, Cristiansen P. Shoulder disability and late symptoms following surgery for early breast cancer. Acta Oncol 2008;47:569-75.
- 15. Lee TS, Kilbreath SL, Refshauge KM, Pendlebury SC, Beith JM, Lee MJ. Pectoral stretching program for women undergoing radiotherapy for breast cancer. Breast Cancer Res Treat 2007;102:313-21.
- 16. Tengrup I, Tennvall-Nittby L, Christiansson I, Laurin M. Arm morbidity after breast-conserving therapy for breast cancer. Acta Oncol 2000;39:393-7.
- 17. Abate M, Silbernagel KG, Siljeholm C, DiIorio A, De Amicis D, Salini V, et al. Pathogenesis of tendinopathies: inflammation or degeneration? Arthritis Res Ther 2009;11:235.
- 18. Ullrich RL, Casarett GW. Interrelationship between the early inflammatory response and subsequent fibrosis after radiation exposure. Radiat Res 1977;72:107-21.
- 19. Van Snellenberg W, Wiley JP, Brunet G. Achilles tendon pain intensity and level of neovascularization in athletes as determined by color Doppler ultrasound. Scand J Med Sci Sports 2007;17:530-4.
- 20. Fu KK, Phillips TL, Kane LJ, Smith V. Tumor and normal tissue response to irradiation in vivo: variation with decreasing dose rates. Radiology 1975;114:709-16.
- 21. Hall EJ. Radiation dose-rate: a factor of importance in radiobiology and radiotherapy. Br J Radiol 1972;45:81-97.
- 22. Poglio S, Galvani S, Bour S, André M, Prunet-Marcassus B, Pénicaud L, et al. Adipose tissue sensitivity to radiation exposure. Am J Pathol 2009;174:44-53.
- 23. Blomqvist L, Stark B, Engler N, Malm M. Evaluation of arm and shoulder mobility and strength after modified radical mastectomy and radiotherapy. Acta Oncol 2004;43:280-3.
- 24. Nagel PH, Bruggink ED, Wobbes T, Strobbe LJ. Arm morbidity after complete axillary lymph node dissection for breast cancer. Acta Chir Belg 2003;103:212-6.
- 25. Klein I, Kalichman L, Chen N, Susmallian S. A comprehensive approach to risk factors for upper arm morbidities following breast cancer treatment: a prospective study. BMC Cancer 2021;21:1251.
Investigation of the impact of radiotherapy on the shoulder joint by ultrasonography in breast cancer patients
Abstract
Objectives: This study aimed to investigate the impact of radiotherapy (RT) on the supraspinatus, long head of the biceps and subscapularis tendons, and shoulder subcutenous fat tissue.
Methods: Patients diagnosed with breast cancer who received RT to the anterior chest wall and axillary-supraclavicular region after breast-conserving surgery or mastectomy in our hospital. Overall, 56 (36 RT, 20 control group) patients were enrolled in this study. Pre-RT, post-RT 6-week, 3-month, and 6-month ultrasonographic and clinical assessments were performed.
Results: The mean interval between surgery and RT was 5.6 (range: 2-8) months. Ten (27.7%) patients developed ultrasonographic abnormalities during the post-RT period. However, only 2 of these patients had shoulder pain and restricted range of motion in the shoulder. The thickness of the supraspinatus, biceps and subscapularis tendons were similar between the dominant and non-dominant sides of the control and RT group patients (5.7 mm vs. 5.1 mm, 2.87 mm vs. 2.89 mm, and 4.13 mm vs. 3.97 mm; respectively, p > 0.05). Thirteen patients were given RT on the ipsilateral side, and 23 received RT on the contralateral side. The pre-RT supraspinatus tendon thickness was significantly higher in the ipsilateral group than in the contralateral group (p = 0.026). However, there was no significant difference in the post-RT period (p = 0.408).
Conclusions: In breast cancer patients undergoing adjuvant RT, RT may cause temporary edema in shoulder tendons. In addition, shoulder pain and restricted range of motion of the shoulder joint can be present in these patients.
References
- 1. Cuzick J. Radiotherapy for breast cancer. J Natl Cancer Inst 2005;97:406-7.
- 2. Overgaard M, Hansen PS, Overgaard J, Rose C, Andersson M, Bach F, et al. Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial. N Engl J Med 1997;337:949-55.
- 3. Ragaz J, Jackson SM, Le N, Plenderleith IH, Spinelli JJ, BascoVE, et al. Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer. N Engl J Med 1997;337:956-62.
- 4. Xiang X, Ding Z, Feng L, Li N. A meta-analysis of the efficacy and safety of accelerated partial breast irradiation versus whole-breast irradiation for early-stage breast cancer. Radiat Oncol 2021;16:24.
- 5. Polgár C, Kahán Z, Ivanov O, Chorváth M, Ligačová A, Csejtei A, et al. Radiotherapy of Breast Cancer-Professional Guideline 1st Central-Eastern European Professional Consensus Statement on Breast Cancer. Pathol Oncol Res 2022;28:1610378.
- 6. Whelan TJ, Julian J, Wright J, Jadad AR, Levine ML. Does locoregional radiation therapy improve survival in breast cancer? A meta-analysis. J Clin Oncol 2000;18:1220-9.
- 7. Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER,et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 2002;347:1233-41.
- 8. Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 2002;347:1227-32.
- 9. Haussmann J, Corradini S, Nestle-Kraemling C, Bölke E, Njanang FJD, Tamaskovics B, et al. Recent advances in radiotherapy of breast cancer. Radiat Oncol 2020;15:71.
- 10. Franjic S. Ultrasound in medicine. Am J Biomed Sci Res 2021;14:362-4.
- 11. Massone E, Orlandi D, Bellelli A, Martino F, Cavagnaro L, Formica M, et al. Real-time fusion-imaging in low back pain: a new navigation system for facet joint injections. Radiol Med 2018;123:851-9.
- 12. Rubin P, Constine LS, Fajardo LF, Phillips TL, Wasserman TH. RTOG Late Effects Working Group. Overview. Late Effects of Normal Tissues (LENT) scoring system. Int J Radiat Oncol Biol Phys 1995;31:1041-2.
- 13. Bentzen SM, Dische S. Morbidity related to axillary irradiation in the treatment of breast cancer. Acta Oncol 2000;39:337-47.
- 14. Lauridsen MC, Overgaard M, Overgaard J, Hessov IB, Cristiansen P. Shoulder disability and late symptoms following surgery for early breast cancer. Acta Oncol 2008;47:569-75.
- 15. Lee TS, Kilbreath SL, Refshauge KM, Pendlebury SC, Beith JM, Lee MJ. Pectoral stretching program for women undergoing radiotherapy for breast cancer. Breast Cancer Res Treat 2007;102:313-21.
- 16. Tengrup I, Tennvall-Nittby L, Christiansson I, Laurin M. Arm morbidity after breast-conserving therapy for breast cancer. Acta Oncol 2000;39:393-7.
- 17. Abate M, Silbernagel KG, Siljeholm C, DiIorio A, De Amicis D, Salini V, et al. Pathogenesis of tendinopathies: inflammation or degeneration? Arthritis Res Ther 2009;11:235.
- 18. Ullrich RL, Casarett GW. Interrelationship between the early inflammatory response and subsequent fibrosis after radiation exposure. Radiat Res 1977;72:107-21.
- 19. Van Snellenberg W, Wiley JP, Brunet G. Achilles tendon pain intensity and level of neovascularization in athletes as determined by color Doppler ultrasound. Scand J Med Sci Sports 2007;17:530-4.
- 20. Fu KK, Phillips TL, Kane LJ, Smith V. Tumor and normal tissue response to irradiation in vivo: variation with decreasing dose rates. Radiology 1975;114:709-16.
- 21. Hall EJ. Radiation dose-rate: a factor of importance in radiobiology and radiotherapy. Br J Radiol 1972;45:81-97.
- 22. Poglio S, Galvani S, Bour S, André M, Prunet-Marcassus B, Pénicaud L, et al. Adipose tissue sensitivity to radiation exposure. Am J Pathol 2009;174:44-53.
- 23. Blomqvist L, Stark B, Engler N, Malm M. Evaluation of arm and shoulder mobility and strength after modified radical mastectomy and radiotherapy. Acta Oncol 2004;43:280-3.
- 24. Nagel PH, Bruggink ED, Wobbes T, Strobbe LJ. Arm morbidity after complete axillary lymph node dissection for breast cancer. Acta Chir Belg 2003;103:212-6.
- 25. Klein I, Kalichman L, Chen N, Susmallian S. A comprehensive approach to risk factors for upper arm morbidities following breast cancer treatment: a prospective study. BMC Cancer 2021;21:1251.
There are 25 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Radiology and Organ Imaging |
| Journal Section | Original Articles |
| Authors | |
| Early Pub Date | May 29, 2023 |
| Publication Date | November 4, 2023 |
| Submission Date | November 13, 2022 |
| Acceptance Date | December 19, 2022 |
| Published in Issue | Year 2023 Volume: 9 Issue: 6 - November 2023 |
e-ISSN: 2149-3189
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