Generally,the computer systems are made up of silicon-based computer technologies. In DNA computing, it is based on the computing techniques of DNA, biochemistry and molecular biology, instead of traditional silicon-based computer technology. Initially,Adleman computed an experiment which instances the Hamiltonian path problem with DNA test tubes in 1994. Then he computed further research on computation with molecular means in theoretical computer science. DNA computing has vast parallelism and high-density storage to solve many problems. Also, DNA has explored as an excellent material and a fundamental building block for developing large scale nanostructures, constructing individual nanomechanical devices, and performing computations. The input and output information will be in the molecular form which is demonstrated by molecular-scale autonomous programmable computers. This paper deals with the review of future advancements in DNA computing and challenges for researchers in future.