Version 1
: Received: 25 March 2020 / Approved: 26 March 2020 / Online: 26 March 2020 (14:27:39 CET)
How to cite:
Tamanoi, F.; Matsumoto, K.; Doan, T.L.H.; Shiro, A.; Saitoh, H. Convergence of the Study on Monochromatic X-rays and the Research on Nanoparticles Opens Up a Possibility to Develop a New Type of Radiation Therapy. Preprints2020, 2020030391. https://doi.org/10.20944/preprints202003.0391.v1
Tamanoi, F.; Matsumoto, K.; Doan, T.L.H.; Shiro, A.; Saitoh, H. Convergence of the Study on Monochromatic X-rays and the Research on Nanoparticles Opens Up a Possibility to Develop a New Type of Radiation Therapy. Preprints 2020, 2020030391. https://doi.org/10.20944/preprints202003.0391.v1
Tamanoi, F.; Matsumoto, K.; Doan, T.L.H.; Shiro, A.; Saitoh, H. Convergence of the Study on Monochromatic X-rays and the Research on Nanoparticles Opens Up a Possibility to Develop a New Type of Radiation Therapy. Preprints2020, 2020030391. https://doi.org/10.20944/preprints202003.0391.v1
APA Style
Tamanoi, F., Matsumoto, K., Doan, T.L.H., Shiro, A., & Saitoh, H. (2020). Convergence of the Study on Monochromatic X-rays and the Research on Nanoparticles Opens Up a Possibility to Develop a New Type of Radiation Therapy. Preprints. https://doi.org/10.20944/preprints202003.0391.v1
Chicago/Turabian Style
Tamanoi, F., Ayumi Shiro and Hiroyuki Saitoh. 2020 "Convergence of the Study on Monochromatic X-rays and the Research on Nanoparticles Opens Up a Possibility to Develop a New Type of Radiation Therapy" Preprints. https://doi.org/10.20944/preprints202003.0391.v1
Abstract
Conventional radiation therapy uses white X-rays that consist of a mixture of X-ray waves with various energy levels. In contrast, a monochromatic X-ray (monoenergetic X-ray) has a single energy level. Irradiation of high Z elements with a synchrotron generated monochromatic X-ray with the energy at or higher than the K-edge energy of the element results in the production of the Auger electrons that cause DNA damage leading to cell killing. Delivery of high Z elements into cancer cells and tumor mass can be facilitated by the use of nanoparticles. Mesoporous silica nanoparticles (MSNs) have been shown to be effective in delivering high Z elements to cancer cells. A proof of principle experiment was reported that demonstrated the feasibility of this approach. This opens up a possibility to pursue the Auger cancer therapy by the combined use of MSNs loaded with high Z elements and monochromatic X-rays. Similar cancer therapies using other types of quantum beams such as neutron, proton and carbon ion beams can be envisioned.
Keywords
monochromatic X-ray; high Z elements; mesoporous silica nanoparticles; tumor spheroids; Auger therapy
Subject
Chemistry and Materials Science, Nanotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.