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Trends in Paper-based Electrochemical Biosensors: From Design to Application

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Abstract

Electrochemical bio-sensing using paper-based detection systems is the main focus of this review. The different existing designs of 2-dimensional and 3-dimensional sensors, and fabrication techniques are discussed. This review highlights the effect of adopting different sensor designs, distinct fabrication techniques, as well as different modification methods, in order to produce reliable and reproducible reading. The use of various nanomaterials have been demonstrated in order to modify the surface of electrodes during fabrication to further enhance the signal for subsequent analysis. The reviewed sensors were classified into categories based on their applications, such as diagnostics, environmental and food testing. One of the major advantages of using paper-based electrochemical sensors is the potential for miniaturization, which only requires relatively small amount of samples, and the low cost for the purpose of mass production. Additionally, most of the devices reviewed were made to be portable, making them well-suited for on-site detection. Finally, paper-based detection is an ideal platform to fabricate cost-effective, user-friendly and sensitive electrochemical biosensors, with large capacity for customization depending on functional needs.

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Acknowledgments

V. B. C. L. and M. U. A. would like to acknowledge the financial support for the project given by the Brunei Research Council of Negara Brunei Darussalam through Grant BRC-10.

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Authors and Affiliations

  1. Biosensors and Biotechnology Laboratory, Integrated Science Building, Faculty of Science, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong, BE 1410, Brunei Darussalam

    Vivian Bee Chin Lee & Minhaz Uddin Ahmed

  2. PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong, BE 1410, Brunei Darussalam

    Noor Faizah Mohd-Naim

  3. Department of Applied, Physics Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Eiichi Tamiya

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  1. Vivian Bee Chin Lee
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Lee, V.B.C., Mohd-Naim, N.F., Tamiya, E. et al. Trends in Paper-based Electrochemical Biosensors: From Design to Application. ANAL. SCI. 34, 7–18 (2018). https://doi.org/10.2116/analsci.34.7

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