Skip to main content
SpringerLink
Log in

Drug Interactions that Matter

A Critical Reappraisal

  • Review Article
  • Published:
Drugs Aims and scope Submit manuscript

Summary

Drug interactions are ubiquitous but those with proven clinical relevance are much less common. Only when the combined effects of the interacting drugs are greater or less than the arithmetic sum of their individual actions can the event be considered a true interaction. This eliminates many candidate ‘interactions’ which in reality merely describe the summation of similar or opposing, but independent, drug effects.

An appreciation of those drug interactions that really do matter can be best achieved by combining a practical knowledge of the pharmacological mechanisms involved with awareness of the most vulnerable patients (those with little reserve capacity) and the drugs associated with the greatest risk (those with a narrow therapeutic index). This review follows these guidelines and provides an account of well documented drug interactions categorised according to mechanism.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Abramson EA, Arky RA, Woeber KA. Effects of propranolol on the hormonal and metabolic responses to insulin-induced hypoglycaemia. Lancet 2: 1386–1388, 1966

    Article  PubMed  CAS  Google Scholar 

  • Addonizio G. Rapid induction of extrapyramidal side effects with combined use of lithium and neuroleptics. Journal of Clinical Psychopharmacology 5: 296–298, 1985

    Article  PubMed  CAS  Google Scholar 

  • Allum W, Aminu J, Bloomfield TH, Davies C, Seales AH, et al. Interaction between debrisoquine and phenylephrine in man. British Journal of Clinical Pharmacology 1: 51–57, 1974

    Article  PubMed  CAS  Google Scholar 

  • Amdisen A. Lithium and drug interactions. Drugs 24: 133–139, 1982

    Article  PubMed  CAS  Google Scholar 

  • Aminu JM, D’Mello A, Vere DW. Interaction between debrisoquine and phenylephrine. Lancet 2: 935–936, 1970

    Article  PubMed  CAS  Google Scholar 

  • Andersson K-E, Bratt L, Dencker H, Kamme C, Lanner E. Inhibition of tetracycline absorption by zinc. European Journal of Clinical Pharmacology 10: 59–62, 1976

    Article  CAS  Google Scholar 

  • Andreason PB, Simonsen K, Brocks K, Dimo B, Bouchelouche P. Hypoglycaemia induced by azapropazone-tolbutamide interaction. British Journal of Clinical Pharmacology 12: 581–583, 1981

    Article  Google Scholar 

  • Anggard E, Jonsson LE, Hogmark A, Gunne LM. Amphetamine metabolism in amphetamine psychosis. Clinical Pharmacology and Therapeutics 14: 870–880, 1973

    PubMed  CAS  Google Scholar 

  • Anya AL, Mayersohn M, Conrad KA, Dimmitt DC. The influence of sucralfate on ibuprofen absorption in healthy adult males. Biopharmaceutics and Drug Disposition 7: 443–451, 1986

    Article  Google Scholar 

  • Back DJ, Bates M, Bowden A, Breckenridge AM, Hall JM, et al. The interaction of phenobarbital and other anticonvulsants with oral contraceptive steroid therapy. Contraception 22: 495–503, 1980a

    Article  PubMed  CAS  Google Scholar 

  • Back DJ, Breckenridge AM, Crawford FE, Hall JM, MacIver M, et al. The effect of rifampicin on the pharmacokinetics of ethinyloestradiol in women. Contraception 21: 135–143, 1980b

    Article  PubMed  CAS  Google Scholar 

  • Bacon BR, Treuhaft WH, Goodman AM. Azathioprine-induced pancytopenia. Archives of Internal Medicine 141: 223–226, 1981

    Article  PubMed  CAS  Google Scholar 

  • Bacon JF, Shenfield GM. Pregnancy attributable to interaction between tetracycline and oral contraceptives. British Medical Journal 280: 293, 1980

    Article  PubMed  CAS  Google Scholar 

  • Bailey RR, Neale TJ. Rapid clonidine withdrawal with blood pressure overshoot exaggerated by beta-blockade. British Medical Journal 1: 942–943, 1976

    Article  PubMed  CAS  Google Scholar 

  • Barber HE, Douglas AS. Drug interactions involving anticoagulant drugs. In Petrie (Ed.) Clinically important adverse drug interactions: cardiovascular and respiratory disease therapy, Vol. 1, pp. 141–152, Elsevier, Amsterdam, 1980

    Google Scholar 

  • Bateman FJA. Effects of tetracyclines. British Medical Journal 4: 802, 1970

    Article  Google Scholar 

  • Baumrucker JK. Drug interaction — propranolol and cafergot. New England Journal of Medicine 288: 916–917, 1973

    PubMed  CAS  Google Scholar 

  • Bechtol LD, Warner WL. Dextrothyroxine for lowering serum cholesterol. Angiology 20: 565–579, 1969

    Article  PubMed  CAS  Google Scholar 

  • Beeley L. Drug interactions and β-blockers. British Medical Journal 289: 1330–1331, 1984

    Article  PubMed  CAS  Google Scholar 

  • Beller GA, Smith TW, Abelmann WH, Haber E, Hood WB. Digitalis intoxication. New England Journal of Medicine 284: 989–997, 1971

    Article  PubMed  CAS  Google Scholar 

  • Belz GG, Docring E, Munkes R, Matthews J. Interaction between digoxin and calcium antagonists and antiarrhythmic drugs. Clinical Pharmacology and Therapeutics 53: 410–417, 1983

    Google Scholar 

  • Bending MR, Skacel PO. Rifampicin and methadone withdrawal. Lancet 1: 1211, 1977

    Article  PubMed  CAS  Google Scholar 

  • Birkett DJ, Miners JO, Attwood J. Evidence for a dual action of sulphinpyrazone on drug metabolism in man: theophylline-sulphinpyrazone interaction. British Journal of Clinical Pharmacology 15: 567–569, 1983

    Article  PubMed  CAS  Google Scholar 

  • Block SH. Carbamazepine-isoniazid interaction. Pediatrics 69: 494–495, 1982

    PubMed  CAS  Google Scholar 

  • Boakes AJ. Antagonism of bethanidine by mazindol. British Journal of Clinical Pharmacology 4: 486–487, 1977

    Article  PubMed  CAS  Google Scholar 

  • Boakes AJ, Laurence DR, Level KW, O’Neil R, Verrill PJ. Adverse reactions to local anaesthetic/vasoconstrictor preparations. British Dental Journal 133: 137–140, 1972

    Article  PubMed  CAS  Google Scholar 

  • Boakes AJ, Laurence DR, Teoh PC, Barar FSK, Benedikter LT, et al. Interaction between sympathomimetic amines and anti-depressant agents in man. British Medical Journal 1: 311–315, 1973

    Article  PubMed  CAS  Google Scholar 

  • Bobrow SN, Jaffe E, Young RC. Anuria and acute tubular necrosis associated with gentamicin and cephalothin. Journal of the American Medical Association 222: 1546–1547, 1972

    Article  PubMed  CAS  Google Scholar 

  • Bollini P, Riva R, Albani F, Ida N, Cacciari L, et al. Decreased phenytoin level during antineoplastic therapy: a case report. Epilepsia 24: 75–78, 1983

    Article  PubMed  CAS  Google Scholar 

  • Bolt HM, Bolt M, Kappus H. Interaction of rifampicin treatment with pharmacokinetics and metabolism of ethinyloestradiol in man. Acta Endocrinologica 85: 189–197, 1977

    PubMed  CAS  Google Scholar 

  • Bolt HM, Kappus H, Bolt M. The effect of rifampicin treatment on the metabolism of oestradiol and 17-ethinyloestradiol by human liver microsomes. European Journal of Clinical Pharmacology 8: 301–307, 1975

    Article  PubMed  CAS  Google Scholar 

  • Boobis AR, Davies DS. Human cytochromes P-450. Xenqbiotica 14: 151–185, 1984

    Article  CAS  Google Scholar 

  • Boylan JJ, Owen DS, Chin JB. Phenytoin interference with dexamethasone. Journal of the American Medical Association 235: 803–804, 1976

    Article  PubMed  CAS  Google Scholar 

  • Breckenridge A. Drug interactions with oral anticoagulants. British Medical Journal 2: 397–400, 1974

    Article  Google Scholar 

  • Breckenridge AM, Back DJ, Orme M. Interactions between oral contraceptives and other drugs. Clinical Pharmacology and Therapeutics 7: 617–626, 1979

    CAS  Google Scholar 

  • Breckenridge AM, Orme ML’E, Thorgiersson S, Davies DS, Brooks RV. Drug interactions with warfarin: studies with dichloral-phenazone, chloral hydrate and phenazone (antipyrine). Clinical Science 40: 351–364, 1971

    PubMed  CAS  Google Scholar 

  • Brennan RW, Dehejia H, Kutt M, Verbely K, McDowall F. Diphenylhydantoin intoxication attendant to slow inactivation of isoniazid. Neurology 20: 687–693, 1970

    Article  PubMed  CAS  Google Scholar 

  • Briant RH, Reid JL, Dollery CT. Interaction between clonidine and desipramine in man. British Medical Journal I: 522–523, 1973

    Article  Google Scholar 

  • Brodie MJ. Adverse drug interactions. In Beattie & Ireland (Eds) Emergencies in medicine, pp. 80–90, Pitman Medical, London, 1983a

    Google Scholar 

  • Brodie MJ. First pass metabolism. Practitioner 227: 1619–1627, 1983b

    PubMed  CAS  Google Scholar 

  • Brodie MJ, Macphee GJA. Carbamazepine neurotoxicity precipitated by diltiazem. British Medical Journal 292: 1170–1171, 1986

    Article  PubMed  CAS  Google Scholar 

  • Brogden RN, Heel RC, Speight TM, Avery GS. Sucralfate. A review of its pharmacodynamic properties and therapeutic use in peptic ulcer disease. Drugs 27: 194–209, 1984

    Article  PubMed  CAS  Google Scholar 

  • Brooks PM, Buchanan WW, Grove M, Downie NW. Effects of enzyme-induction on metabolism of prednisolone: clinical and laboratory study. Annals of the Rheumatic Diseases 35: 339–343, 1976

    Article  PubMed  CAS  Google Scholar 

  • Brooks SM, Werk EE, Ackerman SJ, Sullivan I, Thrasher K. Adverse effects of phenobarbital on corticosteroid metabolism in patients with bronchial asthma. New England Journal of Medicine 286: 1125–1128, 1972

    Article  PubMed  CAS  Google Scholar 

  • Bruni J, Wilder BJ, Perchalski RJ, Hammond EJ, Villareal HJ. Valproic acid and plasma levels of phenobarbital. Neurology 30: 94–97, 1980

    Article  PubMed  CAS  Google Scholar 

  • Buffmgton GA, Dominguez JH, Piering WF, Herbert LA, Kauffmann HM, et al. Interaction of rifampicin and glucocorticoids. Adverse effect on renal allograft function. Journal of the American Medical Association 236: 1958–1960, 1976

    Article  Google Scholar 

  • Burgess CD, Turner P, Wadsworth J. Cardiovascular responses to mianserin hydrochloride: a comparison with tricyclic anti-depressant drugs. British Journal of Clinical Pharmacology 5: 21S–28S, 1978

    PubMed  Google Scholar 

  • Busfield D, Child KJ, Atkinson RM, Tornich EG. The effect of phenobarbitone on blood levels of griseofulvin in man. Lancet 2: 1042–1043, 1963

    Article  PubMed  CAS  Google Scholar 

  • Callaghan JT, Tsuru M, Holtzman JL, Hunninghake DB. Effect of cholestyramine and colestipol on the absorption of phenytoin. European Journal of Clinical Pharmacology 24: 675–678, 1983

    Article  PubMed  CAS  Google Scholar 

  • Carlsson A, Waldeck B. Mechanisms of amine transport in the cell membranes of the adrenergic nerves. Acta Pharmacologica Toxicologica 22: 293–300, 1965

    Article  CAS  Google Scholar 

  • Carranco E, Kareus J, Schenley C, Peak V, Al-Rajeh S. Carbamazepine toxicity induced by concurrent erythromycin therapy. Archives of Neurology 42: 187–188, 1985

    Article  PubMed  CAS  Google Scholar 

  • Carulli N, Manenti F, Gallo M, Salvioli GF. Alcohol-drugs interaction in man: alcohol and tolbutamide. European Journal of Clinical Investigation 1: 421–424, 1971

    Article  PubMed  CAS  Google Scholar 

  • Cass E, Kadar D, Stein HA. Hazards of phenylephrine topical medication in persons taking propranolol. Canadian Medical Association Journal 120: 1261–1262, 1979

    PubMed  CAS  Google Scholar 

  • Chang CC, Costa E, Brodie BB. Interactions of guanethidine with adrenergic neurones. Journal of Pharmacology and Experimental Therapeutics 147: 303–312, 1965

    PubMed  CAS  Google Scholar 

  • Chapron DJ, Numford D, Pitogoff GI. Apparent quinidine-induced digoxin toxicity after withdrawal of pentobarbital: case of sequential drug interactions. Archives of Internal Medicine 139: 363–364, 1979

    Article  PubMed  CAS  Google Scholar 

  • Chennavasin P, Seiwell R, Brater DC. Pharmacokinetic-dynamic analysis of the indomethacin-frusemide interaction in man. Journal of Pharmacology and Experimental Therapeutics 215: 77–81, 1980

    PubMed  CAS  Google Scholar 

  • Choi Y, Thrasher K, Werk EE, Sholiton LJ, Olinger C. Effect of diphenylhydantoin on cortisol kinetics in humans. Journal of Pharmacology and Experimental Therapeutics 176: 27–34, 1971

    PubMed  CAS  Google Scholar 

  • Christensen CC, Boye NP, Erikson H, Hansen G. Influence of pindolol (Visken) on respiratory function in 20 asthmatic patients. European Journal of Clinical Pharmacology 13: 9–12, 1978

    Article  PubMed  CAS  Google Scholar 

  • Ciabottoni G, Pugliese F, Cinotti GA, Patrono C. Renal effects of anti-inflammatory drugs. European Journal of Rheumatology and Inflammation 3: 210–221, 1980

    Google Scholar 

  • Cohen B. The clinical use of dextrothyroxine in hypercholesterolaemic states. Journal of Clinical Pharmacology 9: 45–56, 1969

    CAS  Google Scholar 

  • Coulam CB, Annegers JF. Do anticonvulsants reduce the efficacy of oral contraceptives? Epilepsia 20: 519–526, 1979

    Article  PubMed  CAS  Google Scholar 

  • Cummins LH, Kozak PP, Gillman SA. Theophylline determinations. Annals of Allergy 37: 450–451, 1976

    PubMed  CAS  Google Scholar 

  • Dam M, Kristensen CB, Hansen BS, Christiansen J. Interaction between carbamazepine and propoxyphene in man. Acta Neurologica Scandinavica 56: 603–607, 1977

    Article  PubMed  CAS  Google Scholar 

  • Daneshmend TK, Roberts CJC. The effects of enzyme induction and enzyme inhibition of labetalol pharmacokinetics. British Journal of Clinical Pharmacology 18: 393–400, 1984

    Article  PubMed  CAS  Google Scholar 

  • Daniels NJ, Dover JS, Schachter RK. Interactions between cyclosporin and rifampicin. Lancet ii: 639, 1984

    Article  Google Scholar 

  • Data JL, Wilkinson GR, Nies AS. Interaction of quinidine with anticonvulsant drugs. New England Journal of Medicine 294: 699–792, 1976

    Article  PubMed  CAS  Google Scholar 

  • Davidson NMcD, Corrall RJM, Shaw TDR, French CB. Observations in man of hypoglycaemia during selective and non-selective beta-blockade. Scottish Medical Journal 22: 69–72, 1976

    Google Scholar 

  • Deacon SP, Barnet D. Comparison of atenolol and propranolol during insulin-induced hypoglycemia. British Medical Journal 2: 272–273, 1976

    Article  PubMed  CAS  Google Scholar 

  • Devanesen S. Prolongation of prothrombin time with cimetidine. Medical Journal of Australia 1: 537, 1981

    PubMed  CAS  Google Scholar 

  • Doering W. Quinidine-digoxin interaction: pharmacokinetics, underlying mechanism and clinical implications. New England Journal of Medicine 301: 400–404, 1979

    Article  PubMed  CAS  Google Scholar 

  • Doll R, Langman MJS, Shawdon HH. Treatment of gastric ulcer with carbenoxolone — antagonistic effect of spironolactone. Gut 9: 42–45, 1968

    Article  PubMed  CAS  Google Scholar 

  • Dollery CT, Brodie MJ. Drug interactions. Journal of the Royal College of Physicians of London 14: 190–196, 1980

    PubMed  CAS  Google Scholar 

  • Douste-Blazy Ph, Rostin M, Livarek B, Tordjman E, Montastruc JL, et al. Angiotensin converting enzyme inhibitors and lithium treatment. Lancet 1: 1448, 1986

    Article  PubMed  CAS  Google Scholar 

  • Durao V, Praia MM, Concalves LMP. Modification of antihypertensive effect of β-adrenoceptor blocking agents by inhibition of endogenous prostaglandin synthesis. Lancet ii: 1005–1007, 1977

    Article  Google Scholar 

  • Editorial. Drug interactions with oral contraceptive steroids. British Medical Journal 281: 93–94, 1980

    Article  Google Scholar 

  • Edwards DM, Courtenay-Evans RJ, Galley JM, Hunter J, Tait AD. Changes in cortisol metabolism following rifampicin therapy. Lancet 2: 549–551, 1974

    Article  Google Scholar 

  • Elion GB, Callahan S, Nathan H, Bieber S, Rundles RW, et al. Potentiation by inhibition of drug degradation: 6-substituted purines and xanthine oxidase. Biochemical Pharmacology 12: 85–93, 1963

    Article  CAS  Google Scholar 

  • Elliott HL, McLean K, Sumner DJ, Meredith PA, Reid JL. Immediate cardiovascular responses to prazosin: effect of concurrent beta-blockers. Clinial Pharmacology and Therapeutics 29: 303–309, 1981

    Article  CAS  Google Scholar 

  • EORTC Antimicrobial Therapy Project Group. Three antibiotic regimens in the treatment of infections in febrile granulocytopenic patients with cancer. Journal of Infectious Diseases 137: 14–29, 1978

    Article  Google Scholar 

  • Fann WR, Janowsky DS, Davis JM. Oates JA. Chlorpromazine reversal of the antihypertensive action of guanethidine. Lancet 2: 436–437, 1971

    Article  PubMed  CAS  Google Scholar 

  • Fanning WL, Gump D, Jick H. Gentamicin and cephalothin associated risks in blood urea nitrogen. Antimicrobial Agents and Chemotherapy 10: 80–82, 1976

    Article  PubMed  CAS  Google Scholar 

  • Ferguson RM, Sutherland DER, Simmons RL, Najarian JS. Ketoconazole, cyclosporin metabolism and renal transplantation. Lancet ii: 882–883, 1982

    Article  Google Scholar 

  • Fincham RW, Schottelius DD. Decreased phenytoin levels in antineoplastic therapy. Therapeutic Drug Monitoring 1: 277–283, 1979

    Article  PubMed  CAS  Google Scholar 

  • Formgren H. The effect of metoprolol and practolol in lung function and blood pressure in hypertensive asthmatics. British Journal of Clinical Pharmacology 3: 1007–1014, 1976

    Article  PubMed  CAS  Google Scholar 

  • Friedman HM, Grasela T. Adenine arabinoside and allopurinol — possible adverse drug interaction. New England Journal of Medicine 304: 423, 1981

    Article  PubMed  CAS  Google Scholar 

  • Garfield JW, Kreek MJ, Guisti L. Rifampicin-methadone interaction. American Review of Respiratory Disease 111: 926, 1975

    Google Scholar 

  • Garrod JP, Lambert HP, O’Grady F (Eds). Antibiotics and chemotherapy, 5th ed., Churchill-Livingstone, Edinburgh, 1981

    Google Scholar 

  • Gelipter D, Hazell M. Interaction between disopyramide and practolol. British Medical Journal 280: 52, 1980

    Article  Google Scholar 

  • Gerber MO, Tejwani GA, Gerber N, Bianchine JR. Drug interactions with cimetidine: an update. Pharmacology and Therapeutics 27: 353–370, 1985

    Article  PubMed  CAS  Google Scholar 

  • Girling DJ. Adverse reactions to rifampicin in antituberculous regimens. Journal of Antimicrobial Chemotherapy 3: 115–132, 1977

    Article  PubMed  CAS  Google Scholar 

  • Glogner P, Heni N. Pancytopenia after combined treatment with allopurinol and azathioprine. Medizinische Welt 277: 1545–1546, 1976

    Google Scholar 

  • Graham CF, Turner WN, Jones JK. Lidocaine-propranolol interactions. New England Journal of Medicine 304: 1301, 1981

    PubMed  CAS  Google Scholar 

  • Green AE, Hort JF, Korn HET, Leach H. Potentiation of warfarin by azapropazone. British Medical Journal 1: 1532, 1977

    Article  PubMed  CAS  Google Scholar 

  • Greenberger NJ. Absorption of tetracyclines: interference by iron. Annals of Internal Medicine 74: 792–793, 1971

    PubMed  CAS  Google Scholar 

  • Greenblatt DJ, Koch-Weser J. Adverse reactions to spironolactone: a report from the Boston Collaborative Drug Surveillance Program. Clinical Pharmacology and Therapeutics 14: 136–137, 1973

    Google Scholar 

  • Gugler R, Von Unruh GE. Clinical pharmacokinetics of valproic acid. Clinical Pharmacokinetics 5: 67–83, 1980

    Article  PubMed  CAS  Google Scholar 

  • Gulati OD, Dave BT, Gokhale SD, Shah KM. Antagonism of adrenergic neuron blockade in hypertensive subjects. Clinical Pharmacology and Therapeutics 7: 510–514, 1966

    PubMed  CAS  Google Scholar 

  • Gulati OD, Jaykar S. Factors affecting the action of guanethidine on adrenergic neurones. British Journal of Pharmacology 42: 352–363, 1971

    Article  PubMed  CAS  Google Scholar 

  • Hager WD, Fenster P, Mayersohn M, Perrier D, Graves P, et al. Digoxin-quinidine interaction: pharmacokinetic evaluation. New England Journal of Medicine 300: 1238–1241, 1979

    Article  PubMed  CAS  Google Scholar 

  • Hall GJL, Davis AE. Inhibition of iron absorption by magnesium trisilicate. Medical Journal of Australia 2: 95–96, 1969

    PubMed  CAS  Google Scholar 

  • Hancock KW, Levell MJ. Primidone/dexamethasone interaction. Lancet 2: 97–98, 1978

    Article  PubMed  CAS  Google Scholar 

  • Hansen BS, Dam M, Brandt J, Hvidberg EF, Angelo H, et al. Influence of dextropropoxyphene on steady-state serum levels and protein binding of three anti-epileptic drugs. Acta Neurologica Scandinavica 61: 357–367, 1980

    Article  PubMed  CAS  Google Scholar 

  • Hansen JM, Christensen LJ. Drug interactions with oral sulphonylurea hypoglycaemic drugs. Drugs 13: 24–34, 1977

    Article  PubMed  CAS  Google Scholar 

  • Hansen JM, Kristensen M, Skovsted L. Sulthiame (Ospolot) as inhibitor of diphenylhydantoin metabolism. Epilepsia 9: 17–22, 1968

    Article  PubMed  CAS  Google Scholar 

  • Hansen JM, Siersback-Nielsen K, Kristensen M, Skovsted L, Christensen LK. Effect of diphenylhydantoin on the metabolism of dicoumarol in man. Acta Medica Scandinavica 189: 15–19, 1971

    Article  PubMed  CAS  Google Scholar 

  • Haque N, Thrasher K, Werk EE, Knowles MC, Sholiton LJ. Studies on dexamethasone metabolism in man: effect of diphenylhydantoin. Journal of Clinical Endocrinology and Metabolism 34: 44–50, 1972

    Article  PubMed  CAS  Google Scholar 

  • Heel RC, Brogden RN, Speight TM, Avery GS. Captopril — a preliminary review of its pharmacological properties and therapeutic efficacy. Drugs 20: 409–452, 1980

    Article  PubMed  CAS  Google Scholar 

  • Hendrickse W, McKiernan J, Pickup M, Lowe J. Rifampicin-induced non-responsiveness to corticosteroid treatment with nephrotic syndrome. British Medical Journal 1: 306, 1979

    Article  PubMed  CAS  Google Scholar 

  • Hetzel D, Birkett D, Miners J. Cimetidine interaction with warfarin. Lancet 2: 639, 1979

    Article  PubMed  CAS  Google Scholar 

  • Hetzel DJ, Bochner F, Hallpike JF, Shearman DJC, Hann CS. Cimetidine interaction with phenytoin. British Medical Journal 1: 1512, 1981

    Article  Google Scholar 

  • Hooymans PM, Merkus FWHM. Effect of quinidine on plasma concentrations of digoxin. British Medical Journal 2: 1022, 1978

    Article  PubMed  CAS  Google Scholar 

  • Horder JM. Fatal chlormethiazole poisoning in chronic alcoholics. British Medical Journal 2: 614, 1977

    Article  PubMed  CAS  Google Scholar 

  • Houghton GW, Richens A. Phenytoin intoxication induced by sulthiame in epileptic patients. Journal of Neurology, Neurosurgery and Psychiatry 37: 275–281, 1974a

    Article  CAS  Google Scholar 

  • Houghton GW, Richens A Inhibition of phenytoin metabolism by sulthiame in epileptic patients. British Journal of Clinical Pharmacology 1: 59–66, 1974b

    Article  PubMed  CAS  Google Scholar 

  • Hoyumpa AM, Schenker S. Major drug interactions: effect of liver disease, alcohol and malnutrition. Annual Review of Medicine 33: 113–149, 1982

    Article  PubMed  CAS  Google Scholar 

  • Hunt SN, Jusko WJ, Yurchak AM. Effect of smoking on theophylline disposition. Clinical Pharmacology and Therapeutics 19: 546–551, 1976

    PubMed  CAS  Google Scholar 

  • Hurtig H, Dyson W. Lithium toxicity enhanced by diuretics. New England Journal of Medicine 290: 748–749, 1974

    PubMed  CAS  Google Scholar 

  • Hurwitz A. Antacid therapy and drug kinetics. Clinical Pharmacokinetics 2: 269–280, 1977

    Article  PubMed  CAS  Google Scholar 

  • Iber FL. Drug metabolism in heavy consumers of ethyl alcohol. Clinical Pharmacology and Therapeutics 22: 735–742, 1977

    PubMed  CAS  Google Scholar 

  • Ibram H. Hemodynamic and electrophysiologic interactions between antiarrhythmic drugs and beta-blockers with special reference to tocainide. American Heart Journal 100: 1076–1080, 1980

    Article  Google Scholar 

  • Ifan A, Welling PG. Pharmacokinetics of oral 500mg pencillamine: effect of antacids on absorption. Biopharmaceutics and Drug Disposition 7: 401–405, 1986

    Article  CAS  Google Scholar 

  • Janowsky DS, El Yousef MK, Davis JM, Fann WF, Oates JA. Guanethidine antagonism by antipsychotic drugs. Journal of the Tennessee Medical Association 65: 620–622, 1972

    PubMed  CAS  Google Scholar 

  • Jefferson JW, Greist JH, Carroll J, Baudhuin M. Drug-drug and drug-disease interactions with non-steroidal anti-inflammatory drugs. American Journal of Medicine 81: 948, 1986

    Article  PubMed  CAS  Google Scholar 

  • Jenne JW, Macdonald FM, Mandoza E. A study of the renal clearances, metabolic inactivation rates, and serum fall-off interaction of isoniazid and para-aminosalicylic acid in man. American Review of Respiratory Disease 84: 371–378, 1961

    PubMed  CAS  Google Scholar 

  • Jenne JW, Nagasawa MT, McHugh C, MacDonald F, Wyze E. Decreased theophylline half-life in smokers. Life Science 17: 195–198, 1975

    Article  CAS  Google Scholar 

  • Jick H, Miettinen DS, Shapiro S, Lewis GP, Siskind V, et al. Comprehensive drug surveillance. Journal of the American Medical Association 213: 1455–1460, 1970

    Article  PubMed  CAS  Google Scholar 

  • Johnson AH, Hamilton CH. Kanamycin ototoxicity — possible potentiation by other drugs. Southern Medical Journal 63: 511–513, 1970

    Article  PubMed  CAS  Google Scholar 

  • Johnson J, Freeman JL, Death due to isoniazid (INH) and phenytoin. British Journal of Psychiatry 129: 511, 1976

    PubMed  CAS  Google Scholar 

  • Jones RJ, Cohen L. Sodium dextro-thyroxine in coronary disease and hypercholesteremia. Circulation 24: 164–170, 1961

    Article  PubMed  CAS  Google Scholar 

  • Jones RV. Warfarin and distalgesic interaction. British Medical Journal 1: 460, 1976

    Article  PubMed  CAS  Google Scholar 

  • Jorgenson AW, Sorenson OH. Digitalis intoxication — a comparative study on the incidence of digitalis intoxication during the periods 1950–52 and 1964–66. Acta Medica Scandinavica 188: 179–183,1970

    Article  Google Scholar 

  • Jostell KG, Agurell S, Hollister LE, Wermuth B. Kinetics of chlormethiazole in patients with alcohol withdrawal manifestations. Clinical Pharmacology and Therapeutics 23: 181–187, 1978

    PubMed  CAS  Google Scholar 

  • Jusko WJ, Schentag JS, Clark JH, Gardner M, Yurchak AM. Enhanced biotransformation of theophylline in marijuana and tobacco smokers. Clinical Pharmacology and Therapeutics 24: 405–410, 1978

    PubMed  CAS  Google Scholar 

  • Kapetanovic IM, Kupferberg HJ, Porter RJ, Theodore W, Schulman E, et al. Mechanism of valproate-phenobarbitol interaction in epileptic patients. Clinical Pharmacology and Therapeutics 29: 480–486, 1981

    Article  PubMed  CAS  Google Scholar 

  • Kater RMH, Roggin G, Tobon F, Zieve P, Iber FL. Increased rate of clearance of drugs from the circulation of alcoholics. American Journal of Medical Science 258: 35–39, 1969a

    Article  CAS  Google Scholar 

  • Kater RMH, Tobon F, Iber FL. Increased rate of tolbutamide metabolism in alcoholic patients. Journal of the American Medical Association 207: 363–365, 1969b

    Article  PubMed  CAS  Google Scholar 

  • Kerry RJ, Ludlow JM, Owen G. Diuretics are dangerous with lithium. British Medical Journal 281: 371, 1980

    Article  PubMed  CAS  Google Scholar 

  • Kirch W, Hoensch H, Janisch HD. Interactions and non-interactions with ranitidine. Clinical Pharmacokinetics 9: 493–510, 1984

    Article  PubMed  CAS  Google Scholar 

  • Kirch W, Hutt HJ, Dylewicz P, Graf KJ, Ohnhaus EE. Dose dependence of the nifedipine/digoxin interaction. Clinical Pharmacology and Therapeutics 39: 35–39, 1986a

    Article  PubMed  CAS  Google Scholar 

  • Kirch W, Stenzel J, Dylewicz P, Hutt HJ, Santos SR, et al. Influence of nisoldipine on haemodynamic effects and plasma levels of digoxin. British Journal of Clinical Pharmacology 22: 155–159, 1986b

    Article  PubMed  CAS  Google Scholar 

  • Klein HO, Lang R, Weiss E, Di Segni E, Libhaber C, et al. Influence of verapamil on serum digoxin concentration. Circulation 65: 998–1003, 1982

    Article  PubMed  CAS  Google Scholar 

  • Kleinknecht D, Ganeval D, Droz D. Acute renal failure after high doses of gentamicin and cephalothin. Lancet 1: 1129, 1973

    Article  PubMed  CAS  Google Scholar 

  • Klinenberg JR, Miller F. Effect of corticosteroids on blood salicylate concentrations. Journal of the American Medical Association 194: 601–604, 1965

    Article  PubMed  CAS  Google Scholar 

  • Koch KM, Ludwick BT, Levy RH. Phenytoin-valproic acid interaction in rhesus monkey. Epilepsia 22: 19–25, 1981

    Article  PubMed  CAS  Google Scholar 

  • Kotler MN, Berman L, Rubenstein AH. Hypoglycaemia precipitated by propranolol. Lancet 2: 1389–1390, 1966

    Article  PubMed  CAS  Google Scholar 

  • Kozak PP, Cummins LH, Gillman SA. Administration of erythromycin to patients on theophylline. Journal of Allergy and Clinical Immunology 60: 149–151, 1977

    Article  PubMed  CAS  Google Scholar 

  • Kramer G, Theisohn M, Von Unruh GE, Eichelbaum M. Carbamazepine-danazol drug interaction: its mechanism examined by a stable isotope technique. Therapeutic Drug Monitoring 8: 387–392, 1986

    Article  PubMed  CAS  Google Scholar 

  • Kreck MJ, Garfield JW, Gutjahr CL, Giusti LM. Rifampicin-induced methadone withdrawal. New England Journal of Medicine 294: 1104–1106, 1976

    Article  Google Scholar 

  • Krikler DM, Spurrell RAJ. Verapamil in the treatment of paroxysmal supraventricular trachycardia. Postgraduate Medical Journal 50: 447–453, 1974

    Article  PubMed  CAS  Google Scholar 

  • Kroboth FJ, Kroboth PD, Logan T. Phenytoin-quinidine theophylline interaction. New England Journal of Medicine 308: 725–726, 1982

    Google Scholar 

  • Kuhlmann J, Woodcock B, Wilke J, Rietbroch N. Verapamil plasma concentrations during treatment with cytostatic drugs. Journal of Cardiovascular Pharmacology 7: 1003–1006, 1985

    Article  PubMed  CAS  Google Scholar 

  • Kutt H. Biochemical and genetical factors regulating Dilantin metabolism in man. Annals of New York Academy of Science 179: 704–722, 1971

    Article  CAS  Google Scholar 

  • Kutt H, Brennan R, Dehejia H, Verbely K. Diphenylhydantoin intoxication, a complication of isoniazid therapy. American Review of Respiratory Disease 101: 377–388, 1970

    PubMed  CAS  Google Scholar 

  • Lacey RW, Lord VL, Gunaseberg HKW, Leiberman PJ, Luxton DEA. Comparison of trimethoprim alone and trimethoprim-sulphamethoxazole in the treatment of respiratory and urinary infections with particular reference to the selection of trimethoprim resistance. Lancet 1: 1270–1273, 1980

    Article  PubMed  CAS  Google Scholar 

  • Langhoff E, Madsen S. Rapid metabolism of cyclosporin and prednisone in kidney transplant patients on tuberculostatic treatment. Lancet ii: 1303, 1983

    Article  Google Scholar 

  • Lasagna L. Drug interactions involving appetite suppressants. In Petrie (Ed.) Clinically important adverse drug interactions, Vol. 2, Nervous system, endocrine system and infusion therapy, pp. 219–224, Elsevier, Amsterdam, 1984

    Google Scholar 

  • Leahey EB, Carson JA, Bigger JT, Butler VB. Reduced renal clearance of digoxin during chronic quinidine administration. Circulation 60 (Suppl. 2): 11–16, 1979a

    Google Scholar 

  • Leahey EB, Reiffel JA, Drusin RE, Heisenbuttel RM, Lovejoy WP, et al. Interactions between quinidine and digoxin. Journal of the American Medical Association 240: 533–534, 1978

    Article  PubMed  Google Scholar 

  • Leahey EB, Reiffel JA, Heisenbuttel RM, Drusin RE, Lovejoy WP, et al. Enhanced cardiac effect of digoxin during quinidine treatment. Archives of Internal Medicine 139: 519–521, 1979b

    Article  PubMed  Google Scholar 

  • Lees GM, Flenley DC. Drug interactions involving sympathomimetic amines, xanthines and anticholinergic drugs. In Petrie (Ed.) Clinically important adverse drug interactions, Vol. 1, Cardiovascular and respiratory disease therapy, pp. 153–179, Elsevier, Amsterdam, 1980

    Google Scholar 

  • Leishman AWD, Matthews HL, Smith AJ. Antagonism of guan-ethidine by imipramine. Lancet 1: 112, 1963

    Article  PubMed  CAS  Google Scholar 

  • Lepper MM, Dowling HF. Treatment of penumococcic meningitis with penicillin compared with penicillin plus aureomycin: studies including observations on an apparent antagonism between penicillins and aureomycin. Archives of Internal Medicine 88: 489–494, 1951

    Article  PubMed  CAS  Google Scholar 

  • Letendre PW, Carlson JD, Seifert RD, Dietz AJ, Dimmitt D. Effect of sucralfate on the absorption and pharmacokinetics of chlorpropramide. Journal of Clinical Pharmacology 26: 622–625, 1986

    PubMed  CAS  Google Scholar 

  • Levy RH, Koch KM. Drug interactions with valproic acid. Drugs 24: 543–556, 1982

    Article  PubMed  CAS  Google Scholar 

  • Levy ST, Forrest JN, Heninger GR. Lithium-induced diabetes insipidus: manic symptoms, brain and electrolyte correlates and chlorothiazide treatment. American Journal of Psychiatry 130: 1014–1018, 1973

    PubMed  CAS  Google Scholar 

  • Lewis RJ, Trager WF, Chan KK, Breckenridge A, Orme M, et al. Warfarin: stereochemical aspects of its metabolism and the interaction with phenylbutazone. Journal of Clinical Investigation 53: 1607–1617, 1974

    Article  PubMed  CAS  Google Scholar 

  • Liegler DG, Henderson FS, Holm MA, Oliverio VT. The effect of organic acids on renal clearance of methotrexate in man. Clinical Pharmacology and Therapeutics 10: 849–857, 1969

    PubMed  CAS  Google Scholar 

  • Lindenbaum J, Rund DG, Butler VP, Tse-Eng D, Saha JR. Inactivation of digoxin by the gut flora: reversal by antibiotic therapy. New England Journal of Medicine 305: 789–794, 1981

    Article  PubMed  CAS  Google Scholar 

  • Lloyd-Mostyn RH, Oram S. Modification by propranolol of cardiovascular effects of induced hypoglycaemia. Lancet 1: 1213–1215, 1975

    Article  PubMed  CAS  Google Scholar 

  • Lopez-Ovejero JA, Weber MA, Drayer JIM, Sealey JE, Laragh JH. Effects of indomethacin alone and during diuretic or β-adrenoceptor blockade therapy on blood pressure and the renin system in essential hypertension. Clinical Science 55 (Suppl. 4): 203S–205S, 1978

    CAS  Google Scholar 

  • MacCallum WAG. Interaction of lithium and phenytoin. British Medical Journal 280: 610–611, 1980

    Article  PubMed  CAS  Google Scholar 

  • MacDonald MG, Robinson DS. Clinial observations on possible barbiturate interference with anticoagulation. Journal of the American Medical Association 204: 95–99, 1968

    Article  Google Scholar 

  • Macfie AA. Lithium poisoning precipitated by diuretics. British Medical Journal 1: 516, 1975

    Article  PubMed  CAS  Google Scholar 

  • Mackay G, Muir AL, Watson ML. Contribution of prostaglandins to the systemic and renal vascular responses to frusemide in normal man. British Journal of Clinical Pharmacology 17: 573–579, 1984

    Article  Google Scholar 

  • MacNeil S, Hansen-Nortey E, Paschalis C, Eastwood PR, Jenner FA. Diuretics during lithium therapy. Lancet 1: 1295–1296, 1975

    Article  PubMed  CAS  Google Scholar 

  • Macphee GJA, Brodie MJ. Carbamazepine substitution in severe partial epilepsy: implication of autoinduction of metabolism. Postgraduate Medical Journal 61: 779–783, 1985

    Article  PubMed  CAS  Google Scholar 

  • Macphee GJA, McInnes GT, Thompson GG, Brodie MJ. Verapamil potentiates carbamazepine neurotoxicity: a clinically important inhibitory interaction. Lancet 1: 700–703, 1986

    Article  PubMed  CAS  Google Scholar 

  • Macphee GJA, Thompson GG, Scobie G, Agnew E, Park BK, et al. Effect of cimetidine on carbamazepine auto- and heteroinduction in man. British Journal of Clinical Pharmacology 18: 411–419, 1984

    Article  PubMed  CAS  Google Scholar 

  • Maisey DN, Brown RC, Day JL. Rifampicin and cortisone replacement therapy. Lancet 2: 896–897, 1974

    Article  PubMed  CAS  Google Scholar 

  • Manfredi RL, Vesell ES. Inhibition of theophylline metabolism by long-term allopurinol administration. Clinical Pharmacology and Therapeutics 29: 224–229, 1981

    Article  PubMed  CAS  Google Scholar 

  • Mapp RK, McCarthy T. The effect of zinc sulphate and of bicitropeptide on tetracycline absorption. South African Medical Journal 50: 1829–1830, 1976

    PubMed  CAS  Google Scholar 

  • Marquis JF, Carruthers SG, Spence JD, Brownstone VS, Toogood JH. Phenytoin-theophylline interaction. New England Journal of Medicine 307: 1189–1190, 1982

    Article  PubMed  CAS  Google Scholar 

  • Martell R, Henrichs D, Stiller CR, Jenner M, Keown PA, et al. The effects of erythromycin in patients treated with cyclosporin. Annals of Internal Medicine 104: 660–661, 1986

    PubMed  CAS  Google Scholar 

  • Mathog RH, Klein WJ. Ototoxicity of ethacrynic acid and aminoglycoside antibiotics in uremia. New England Journal of Medicine 280: 1223–1224, 1969

    Article  PubMed  CAS  Google Scholar 

  • Mattson RH, Cramer JA, Williamson PC, Novelly RA. Valproic acid in epilepsy: clinical and pharmacological effects. Annals of Neurology 3: 20–25, 1978

    Article  PubMed  CAS  Google Scholar 

  • May DC, Jarboe LJ, Ellenburg DT, Roe RJ, Karibo J. The effects of erythromycin on theophylline elimination in normal males. Journal of Clinical Pharmacology 22: 125–130, 1982

    PubMed  CAS  Google Scholar 

  • May FE, Stewart RB, Cluff LE. Drug use in the hospital: evaluation of determinants. Clinical Pharmacology and Therapeutics 16: 834–845, 1974

    PubMed  CAS  Google Scholar 

  • McElnay JC, D’Arcy PF. Interaction between azaproprazone and warfarin. British Medical Journal 2: 773–774, 1977

    Article  PubMed  CAS  Google Scholar 

  • McInnes GT. Chlormethiazole and alcohol: a lethal cocktail. British Medical Journal 294: 592, 1987

    Article  PubMed  CAS  Google Scholar 

  • McInnes GT, Findlay IN, Murray G, Cleland JGF, Dargie HJ. Cardiovascular responses to verapamil and propranolol in hypertensive patients. Journal of Hypertension 3 (Suppl. 3): S219–S221, 1985

    PubMed  CAS  Google Scholar 

  • McInnes GT, Helenglass G. The performance of clinics for outpatient control of anticoagulation. Journal of the Royal College of Physicians of London 21: 42–45, 1987

    PubMed  CAS  Google Scholar 

  • McInnes GT, Ramsay LE. Pharmacology and clinical use of antimineralcorticoids. In Furr & Wakeling (Eds) Pharmacology and clinical uses of inhibitors of hormone secretion and action, pp. 233–254, Bailliere Tindall, London, 1987

    Google Scholar 

  • McInnes GT, Thomson GD, Murray GD, Thompson GG, Brodie MJ. Intravenous verapamil during β-adrenoceptor blockade with propranolol. British Journal of Clinical Pharmacology 21: 580P, 1986

    Google Scholar 

  • McInnes GT, Young RE, Avery BS. Cardiac arrest following chlormethiazole infusion in chronic alcoholics. Postgraduate Medical Journal 56: 742–743, 1980

    Article  PubMed  CAS  Google Scholar 

  • McKibbin JK, Pocock WA, Barlow JB, Miller RNS, Obel IWP. Sotalol, hypokalaemia, syncope and torsade de pointes. British Heart Journal 51: 157–162, 1984

    Article  PubMed  CAS  Google Scholar 

  • McLelland J, Jack W. Phenytoin/dexamethasone interaction: a clinical problem. Lancet 1: 1096–1097, 1978

    Article  PubMed  CAS  Google Scholar 

  • Meriwether WD, Mangi RJ, Serpick AA. Deafness following standard intravenous dose of ethacrynic acid. Journal of the American Medical Association 216: 795–798, 1971

    Article  PubMed  CAS  Google Scholar 

  • Miller RR, Porter J, Greenblatt DJ. Clinical importance of the interaction of phenytoin and isoniazid: a report from the Boston Collaborative Drug Surveillance Program. Chest 75: 356–358, 1979

    Article  PubMed  CAS  Google Scholar 

  • Miners JO, Foenander T, Wanwimolruk S, Gallus AS, Birkett DJ. The effect of sulphinpyrazone on oxidative drug metabolism in man: inhibition of tolbutamide elimination. European Journal of Clinical Pharmacology 22: 321–326, 1982a

    Article  PubMed  CAS  Google Scholar 

  • Miners JO, Foenander T, Wanwimolruk S, Gallus AS, Birkett DJ. Interaction of sulphinpyrazone with warfarin. European Journal of Clinical Pharmacology 22: 327–331, 1982b

    Article  PubMed  CAS  Google Scholar 

  • Misage JR, McDonald RH. Antagonism of hypotensive action of bethanidine by ‘common cold’ remedy. British Medical Journal 4: 347, 1970

    Article  PubMed  CAS  Google Scholar 

  • Mitchell JR, Arias L, Oates LA. Antagonism of the action of guanethidine sulphate by desipramine HC1. Journal of the American Medical Association 202: 973–976, 1967

    Article  PubMed  CAS  Google Scholar 

  • Mitchell JR, Cavanagh JH, Arias L, Oates JA. Guanethidine and related agents, III: antagonism by drugs which inhibit the norepinephrine pump in man. Journal of Clinical Investigation 49: 1596–1604, 1970

    Article  PubMed  CAS  Google Scholar 

  • Moochhala SM, Renton KW. Inhibition of hepatic microsomal drug metabolism by the immunosuppressive agent cyclosporin A. Biochemical Pharmacology 35: 1499–1503, 1986

    Article  PubMed  CAS  Google Scholar 

  • Moysey JO, Jaggarao NSV, Grunoy EN, Chamberlain DA. Amiodarone increases plasma digoxin concentrations. British Medical Journal 282: 272, 1981

    Article  PubMed  CAS  Google Scholar 

  • Muakkassah SF, Yang WCT. Mechanism of the inhibitory action of phenalzone on microsomal drug metabolism. Journal of Pharmacology and Experimental Therapeutics 219: 147–155, 1981

    PubMed  CAS  Google Scholar 

  • Murray FJ. Outbreak of unexpected reactions among epileptics taking isoniazid. American Review of Respiratory Disease 86: 729–732, 1962

    PubMed  CAS  Google Scholar 

  • Nappi J. Warfarin and phenytoin interaction. Annals of Internal Medicine 90: 852, 1979

    PubMed  CAS  Google Scholar 

  • Nenci GG, Agnelli G, Berrettini M. Biphasic sulphinpyrazone-warfarin interaction. British Medical Journal 282: 1361–1362, 1981

    Article  PubMed  CAS  Google Scholar 

  • Neuvonen PJ. Interference of iron with the absorption of tetracyclines in man. British Medical Journal 4: 532–534, 1970

    Article  PubMed  CAS  Google Scholar 

  • Neuvonen PJ. Interactions with the absorption of tetracyclines. Drugs 11: 45–54, 1976

    Article  PubMed  CAS  Google Scholar 

  • Neuvonen PJ, Jaakkola A, Totterman J, Pentilla O. Clinically significant sucralfate-warfarin interaction is not likely. British Journal of Clinical Pharmacology 20: 178–180, 1985

    Article  PubMed  CAS  Google Scholar 

  • Neuvonen PJ, Lehtovaara R, Bardy A, Elonen E. Antipyrine analgesic in patients on antiepileptic drug therapy. European Journal of Clinical Pharmacology 15: 263–268, 1979

    Article  PubMed  CAS  Google Scholar 

  • Newman RJ. Comparison of propranolol, metaprolol and acebutolol in insulin-induced hypoglycaemia. British Medical Journal 2: 447–449, 1976

    Article  PubMed  CAS  Google Scholar 

  • Nimmo WS. Drugs, disease and altered gastric emptying. Clinical Pharmacokinetics 1: 189–203, 1976

    Article  PubMed  CAS  Google Scholar 

  • Norrby R, Stenqvist K, Elgeford B. Interactions between cephaloridine and frusemide in man. Scandinavian Journal of Infectious Disease 8: 209–212, 1976

    CAS  Google Scholar 

  • Notelovitz M, Tjapker J, Ware M. Interaction between estrogen and Dilantin in a menopausal woman. New England Medical Journal 304: 788–789, 1981

    Article  CAS  Google Scholar 

  • Ober KF, Wang RIM. Drug interactions with guanethidine. Clinical Pharmacology and Therapeutics 14: 190–195, 1973

    PubMed  CAS  Google Scholar 

  • Oetgen WJ, Sobol SM, Tri TB, Heydorn WH, Rakita L. Amiodarone-digoxin interaction: clinical and experimental observations. Chest 86: 75–79, 1984

    Article  PubMed  CAS  Google Scholar 

  • Oh TE. Frusemide and lithium toxicity. Anaesthetics and Intensive Care 5: 60–62, 1977

    CAS  Google Scholar 

  • Olesen OV, Jensen ON. Drug interaction between sulthiame (Ospolot) and phenytoin in the treatment of epilepsy. Danish Medical Bulletin 16: 154–158, 1969

    PubMed  CAS  Google Scholar 

  • Oliver MF, Roberts SD, Hayes D, Pantridge JF, Suyman MM, et al. Effect of Atromid and ethyl chloraphenocyisobutyrate on anticoagulant requirements. Lancet 1: 143–144, 1963

    Article  PubMed  CAS  Google Scholar 

  • O’Reilly RA. Interactions with sodium warfarin and rifampicin: studies in man. Annals of Internal Medicine 81: 337–340, 1974

    PubMed  Google Scholar 

  • O’Reilly RA. The stereoselective interaction of warfarin and metronidazole in man. New England Journal of Medicine 295: 345–357, 1976

    Google Scholar 

  • Orme M, Breckenridge A. Enantiomers of warfarin and phenobarbital. New England Journal of Medicine 295: 1482–1483, 1976

    PubMed  CAS  Google Scholar 

  • Orme M, Breckenridge A, Cook P. Warfarin and Distalgesic interaction. British Medical Journal 1: 200, 1976

    Article  PubMed  CAS  Google Scholar 

  • Owens JC, Neely WB, Owen WR. Effect of sodium dextrothyroxine in patients receiving anticoagulants. New England Journal of Medicine 266: 76–79, 1962

    Article  PubMed  CAS  Google Scholar 

  • Patak RV, Mookerjee BK, Bentzel CJ, Hysert PE, Babej M, et al. Antagonism of the effects of furosemide by indomethacin in normal and hypertensive man. Prostaglandins 10: 649–658, 1975

    Article  PubMed  CAS  Google Scholar 

  • Patel JH, Levy RM, Cutler RE. Phenobarbital-valproic acid interaction in normal man. Clinical Pharmacology and Therapeutics 27: 515–521, 1980

    Article  PubMed  CAS  Google Scholar 

  • Pedersen KE, Dorph-Pedersen A, Hvidt A, Klitgaard NA, Kjaer K, et al. Effect of nifedipine on digoxin kinetics in healthy subjects. Clinical Pharmacology and Therapeutics 32: 562–565, 1982

    Article  PubMed  CAS  Google Scholar 

  • Pedersen KE, Tayssem P, Klitgaard NA, Christiansen BD, Nielsen-Kudski F. Influence of verapamil on the inotropism and pharmacokinetics of digoxin. European Journal of Clinical Pharmacology 25: 199–206, 1983

    Article  PubMed  CAS  Google Scholar 

  • Pedrinelli R, Magagna A, Arzilli F, Sassano P, Salvetti A. Influence of indomethacin on the natriuretic and renin-stimulating effect of bumetanide in essential hypertension. Clinical Pharmacology and Therapeutics 28: 722–731, 1981

    Google Scholar 

  • Peet M, Middlemiss DN, Yates RA. Propranolol in schizophrenia. II. Clinical and biochemical aspects of combining propranolol with chlorpromazine. British Journal of Psychiatry 138: 112–117, 1981

    Article  Google Scholar 

  • Perucca E, Hebdige S, Gatti G, Lecchini S, Frigo GM, et al. Interaction between phenytoin and valproic acid: plasma protein binding and metabolic effects. Clinical Pharmacology and Therapeutics 28: 779–789, 1980

    Article  PubMed  CAS  Google Scholar 

  • Perucca E, Richens A. Drug interactions involving drugs used in the treatment of epilepsy. In Petrie (Ed.) Clinically important adverse drug interactions, Vol. 2, Nervous system, endocrine system and infusion therapy, pp. 99–145, Elsevier, Amsterdam, 1984

    Google Scholar 

  • Petereit LB, Meikle AW. Effectiveness of prednisolone during phenytoin therapy. Clinical Pharmacology and Therapeutics 22: 912–916, 1977

    PubMed  CAS  Google Scholar 

  • Petersen V, Hvidt S, Thomsen K, Schon M. Effect of prolonged thiazide treatment of renal lithium clearance. British Medical Journal 3: 143–145, 1974

    Article  PubMed  CAS  Google Scholar 

  • Petrie JC, Cluff LE. Evaluation of drug interactions. In Petrie (Ed.) Clinically important adverse drug interactions, Vol. 1, Cardiovascular and respiratory disease therapy, pp. 1–5. Elsevier, Amsterdam, 1980

    Google Scholar 

  • Petrie JC, Howie JGR, Durno D. Awareness and experience of general practitioners of selected drug interactions. British Medical Journal 2: 262–264, 1974

    Article  PubMed  CAS  Google Scholar 

  • Pfeifer HJ, Greenblatt DJ. Clinical toxicity of theophylline in relation to cigarette smoking: a report from the Boston Collaborative Drug Surveillance Program. Chest 73: 455–459, 1978

    Article  PubMed  CAS  Google Scholar 

  • Pfeifer HJ, Greenblatt DJ, Friedman P. Effect of antibiotics on theophylline kinetics in humans. Clinical Pharmacology and Therapeutics 23: 124–125, 1978

    Google Scholar 

  • Philp JR. Drug adverse reactions and interactions involving sulfonamides, trimethoprim, nitrofurantoin, nalidixic acid, fusidic acid, polymixins and bacitracin. In Petrie (Ed.) Clinically important adverse drug interactions, Vol. 3, Gastrointestinal, haematological and infections disease therapy, pp. 155–195, Elsevier, Amsterdam, 1985

    Google Scholar 

  • Pisani F, Fazio A, Oteri G, Perruca E, Trio R, et al. Carbamazepine-viloxazine interaction in patients with epilepsy. Journal of Neurology, Neurosurgery and Psychiatry 49: 1142–1145, 1986

    Article  CAS  Google Scholar 

  • Potaux L, Aparicio M, Roquebert J-P, Conti C, Pauly P. The haematological dangers of combined treatment with azathioprine and allopurinol. Bordeaux Medicin 9: 789–794, 1976

    CAS  Google Scholar 

  • Powell JR, Thiercelin J-F, Vazeh S, Sansom L, Riegelman S. The influence of cigarette smoking and sex on the theophylline disposition. American Review of Respiratory Disease 116: 17–24, 1977

    PubMed  CAS  Google Scholar 

  • Powell-Jackson PR. Interaction between azapropazone and warfarin. British Medical Journal 1: 1193–1194, 1977

    Article  PubMed  CAS  Google Scholar 

  • Powles R, Shinebourne E, Hamer J. Selective cardiac sympathetic blockade as an adjunct to bronchodilator therapy. Thorax 24: 616–618, 1969

    Article  PubMed  CAS  Google Scholar 

  • Prince RA, Wing DS, Weinberger MM, Hendeles LS, Riegelman S. Effect of erythromycin on theophylline kinetics. Journal of Allergy and Clinical Immunology 68: 427–431, 1981

    Article  PubMed  CAS  Google Scholar 

  • Ptachcinski RJ, Carpenter BJ, Burckart GJ, Venkataramanan R, Rosenthal JT. Effect of erythromycin on cyclosporin levels. New England Journal of Medicine 313: 1416–1417, 1985

    PubMed  CAS  Google Scholar 

  • Puurunen J, Pelkonen O. Cimetidine inhibits microsomal drug metabolism in the rat. European Journal of Pharmacology 55: 335–336, 1980

    Article  Google Scholar 

  • Ragheb M, Powell AL. Lithium interaction with sulindac and naproxen. Journal of Clinial Psychopharmacology 6: 150–154, 1986

    CAS  Google Scholar 

  • Reed RC, Schwartz HJ. Phenytoin-theophylline-quinidine interaction. New England Journal of Medicine 308: 724–725, 1982

    Google Scholar 

  • Reigelman S, Rowland M, Epstein WL. Griseofulvin-phenobarbital interaction in man. Journal of the American Medical Association 213: 426–431, 1970

    Article  Google Scholar 

  • Reisz G, Pingleton SK, Melethil S, Ryan PB. The effect of erythromycin on theophylline pharmacokinetics in chronic bronchitis. American Review of Respiratory Disease 127: 581–584, 1983

    PubMed  CAS  Google Scholar 

  • Rendic S, Sunjic V, Toso R, Kaifez F, Ruf HH. Interaction of cimetidine with liver microsomes. Xenobiotica 9: 555–564, 1979

    Article  PubMed  CAS  Google Scholar 

  • Renton KW, Gray JD, Hung OR. Depression of theophylline elimination by erythromycin. Clinical Pharmacology and Therapeutics 30: 422–426, 1981

    Article  PubMed  CAS  Google Scholar 

  • Reveno WS, Rosenbaum H. Propranolol and hypoglycemia. Lancet 1: 920, 1968

    Article  PubMed  CAS  Google Scholar 

  • Ridgway D, Renholds DC, Merhout RC, Wolff LJ. Vincristine in the etiology of toxicity of high dose methotrexate therapy. Cancer 46: 2571–2572, 1980

    Article  PubMed  CAS  Google Scholar 

  • Robson RH, Vishwanath MC. Nifedipine and beta-blockade as a cause of heart failure. British Medical Journal 284: 104, 1982

    Article  PubMed  CAS  Google Scholar 

  • Rodensky PL, Wasserman F. Observation in digitalis intoxication. Archives of Internal Medicine 108: 171–188, 1961

    Article  PubMed  CAS  Google Scholar 

  • Rodin EA, De Sousa G, Haidukewyck D, Lodhi R, Berchou RC. Dissociation between free and bound phenytoin levels in the presence of valproic acid. Archives of Neurology 38: 240–242, 1981

    Article  PubMed  CAS  Google Scholar 

  • Rogers HJ, Haslam RA, Longstreeth J, Lietman PS. Phenytoin intoxication during concurrent diazepam therapy. Journal of Neurology, Neurosurgery and Psychiatry 40: 890–895, 1977

    Article  CAS  Google Scholar 

  • Ross JRY, Beeley L. Interaction between carbamazepine and warfarin. British Medical Journal 1: 1415–1416, 1980

    Article  Google Scholar 

  • Ross WB, Roberts D, Griffin PJA, Salaman JR. Cyclosporin interactions with danazol and norethisterone. Lancet 1: 330, 1986

    Article  PubMed  CAS  Google Scholar 

  • Rowland M. Amphetamine blood and urine levels in man. Journal of Pharmaceutical Science 58: 508–509, 1969

    Article  CAS  Google Scholar 

  • Salvetti A, Arzilli F, Pedrinelli R, Beggi P, Motolose M. Interaction between oxprenolol and indomethacin in blood pressure in essential hypertensive patients. European Journal of Clinical Pharmacology 22: 197–201, 1982

    Article  PubMed  CAS  Google Scholar 

  • Scheiner J, Altemeier WA. Experimental study of factors inhibiting absorption and effective therapeutic levels of declomycin. Surgery, Gynaecology and Obstetrics 114: 9–11, 1962

    CAS  Google Scholar 

  • Seabra-Gomes R, Rickards A, Sutton R. Haemodynamic effects of verapamil and practolol in man. European Journal of Cardiology 4: 79–85, 1976

    PubMed  CAS  Google Scholar 

  • Self TH, Morris T. Interaction of rifampicin and chlorpropamide. Chest 77: 800–801, 1980

    Article  PubMed  CAS  Google Scholar 

  • Serlin MJ, Sibeon RG, Mossman S, Breckenridge AM, Williams JRB, et al. Cimetidine: interaction with oral anticoagulants in man. Lancet 2: 317–319, 1979

    Article  PubMed  CAS  Google Scholar 

  • Shapiro S, Slone D, Lewis GP, Jick H. The epidemiology of digoxin. Journal of Chronic Disease 22: 361–371, 1969

    Article  CAS  Google Scholar 

  • Shukla S, Godwin CD, Long LEB, Miller MG. Lithium-carbamazepine neurotoxicity and risk factors. American Journal of Psychiatry 141: 1604–1606, 1984

    PubMed  CAS  Google Scholar 

  • Silver BA, Bell WK. Cimetidine potentiation of the hypoprothrombinaemic effect of warfarin. Annals of Internal Medicine 89: 348–349, 1979

    Google Scholar 

  • Simpson FO, Waal-Manning HJ. Hypertension and depression: interrelated problems in therapy. Journal of the Royal College of Physicians of London 1: 14–24, 1971

    Google Scholar 

  • Skinner C, Coull DL, Johnston AW. Antagonism of the anti-hypertensive action of bethanidine and debrisoquine by tricyclic antidepressants. Lancet 2: 564–566, 1969

    Article  PubMed  CAS  Google Scholar 

  • Smart HL, Somerville KW, Williams J, Richens A, Langman MJS. The effect of sucralfate upon phenytoin absorption in man. British Journal of Clinical Pharmacology 20: 238–240, 1985

    Article  PubMed  CAS  Google Scholar 

  • Smith JW, Seidl LG, Cluff LE. Studies on the epidemiology of adverse drug reactions. V. Clinical factors influencing susceptibility. Annals of Internal Medicine 65: 629–640, 1966

    PubMed  CAS  Google Scholar 

  • Smith M. Drug interactions involving infusion therapy. In Petrie (Ed.) Clinically important adverse drug interactions, Vol. 2, Nervous system, endocrine system and infusion therapy, pp. 329–355, Elsevier, Amsterdam, 1984

    Google Scholar 

  • Solomon HM, Schrogie JJ. Change in receptor site affinity: a proposed explanation for the potentiating effect of D-throxine on the anticoagulant response to warfarin. Clinical Pharmacology and Therapeutics 2: 797–799, 1967

    Google Scholar 

  • Sotaniemi E, Arvela P, Huhiti E. Increased clearane of tolbutamide from the blood of asthmatic patients. Annals of Allergy 29: 139–141, 1971

    PubMed  CAS  Google Scholar 

  • Southren AL, Gordon GG, Tochimoto S, Krikun E, Krieger D, et al. Effect of N-phenylbarbital (Phetharbital) on the metabolism of testosterone and cortisol in man. Journal of Clinical Endocrinology 29: 251–256, 1969

    Article  CAS  Google Scholar 

  • Starke K. Interactions of guanethidine and indirect-acting sympathomimetic amines. Archives Internationales de Pharmacodynamie et de Therapie 195: 309–314, 1972

    PubMed  CAS  Google Scholar 

  • Starr KF, Petrie JC. Drug interactions in patients on long-term oral anticoagulant and antihypertensive adrenergic neuron-blocking drugs. British Medical Journal 4: 133–135, 1972

    Article  PubMed  CAS  Google Scholar 

  • Steiness E. Suppression of renal excretion of digoxin in hypokalaemic patients. Clinical Pharmacology and Therapeutics 23: 511–514, 1978

    PubMed  CAS  Google Scholar 

  • Steiness E, Olesen KH. Cardiac arrhythmias induced by hypokalaemia and potassium loss during maintenance digoxin therapy. British Heart Journal 38: 167–172, 1976

    Article  PubMed  CAS  Google Scholar 

  • Stjernholm MR, Katz FH. Effects of diphenylhydantoin, phenobarbital and diazepam on the metabolism of methylprednisolone and its sodium succinate. Journal of Clinical Endocrinology and Metabolism 41: 887–893, 1975

    Article  PubMed  CAS  Google Scholar 

  • Stone C, Porter C, Stavarski J, Ludden C, Totaro J. Antagonism of certain effects of catecholamine depleting agents by anti-depressants and related drugs. Journal of Pharmacology and Experimental Therapeutics 144: 196–204, 1964

    PubMed  CAS  Google Scholar 

  • Straub KD, Kane JJ, Bissen JK, Doherty JE. Alteration of digitalis binding by quinidine: a mechanism of digitalis-quinidine interaction. Circulation 58 (Suppl. 2): 11–58, 1978

    Google Scholar 

  • Svedmyr N. The influence of a tricyclic antidepressive agent (proptriptyline) on some of the circulatory effects of noradrenaline and adrenaline in man. Life Science 7: 77–84, 1968

    Article  CAS  Google Scholar 

  • Syvalahti EKG, Rhilajamaki KK, Iisola EJ. Rifampicin and drug metabolism. Lancet 2: 232–233, 1974

    Article  PubMed  CAS  Google Scholar 

  • Tellerman-Toppet N, Duret ME, Loers C. Cimetidine interaction with carbamazepine. Annals of Internal Medicine 94: 544, 1981

    Google Scholar 

  • Thiringer G, Svedmyr N. Interaction of orally administered metoprolol, practolol and propranolol with isoprenaline in asthmatics. European Journal of Clinical Pharmacology 10: 163–170, 1976

    Article  Google Scholar 

  • Tilstone WJ, Gray JMB, Nimmo-Smith RH, Lawson DH. Interaction between warfarin and sulphamethoxazole. Postgraduate Medical Journal 53: 388–390, 1977

    Article  PubMed  CAS  Google Scholar 

  • Tollefson GD. Monoamine oxidase inhibitors: a review. Journal of Clinical Psychiatry 44: 280–286, 1983

    PubMed  CAS  Google Scholar 

  • Udall JA. Drug interference with warfarin therapy. Clinical Medicine 77: 20–25, 1970

    CAS  Google Scholar 

  • Uribe M, Casian C, Rojas S, Sierra JG, Go VLM. Decreased bioavailability of prednisolone due to antacids in patients with chronic active liver disease and in healthy volunteers. Gastroenterology 80: 661–665, 1981

    PubMed  CAS  Google Scholar 

  • Vajda FJE, Prineas RJ, Lovell RRH. Interaction between phenytoin and the benzodiazepines. British Medical Journal 1: 346, 1971

    Article  PubMed  CAS  Google Scholar 

  • Valsalan VC, Cooper GL. Carbamazepine intoxication caused by interaction with isoniazid. British Medical Journal 285: 261–262, 1982

    Article  PubMed  CAS  Google Scholar 

  • Van Marle W, Woods KL, Beeley L. Concurrent steroid and rifampicin therapy. British Medical Journal 1: 1020, 1979

    Article  PubMed  Google Scholar 

  • Venter CP, Jollbert PH, Buys AC. Severe peripheral ischaemia during concomitant use of beta-blockers and ergot alkaloids. British Medical Journal 289: 288–289, 1984

    Article  PubMed  CAS  Google Scholar 

  • Vestal RE, Kornhauser DM, Hollifield JW, Shand DG. Inhibition of propranolol metabolism by chlorpromazine. Clinical Pharmacology and Therapeutics 25: 19–24, 1979

    PubMed  CAS  Google Scholar 

  • Vilsvik JS, Schaaning J. Effect of atenolol on ventilatory and cardiac function in asthma. British Medical Journal 2: 453–455, 1976

    Article  PubMed  CAS  Google Scholar 

  • Vincent FM. Phenothiazine-induced phenytoin intoxication. Annals of Internal Medicine 93: 56–57, 1980

    PubMed  CAS  Google Scholar 

  • Volans GN. Drug interactions in rheumatoid disease — are they of any clinical importance? Rheumatology Rehabilitation (Suppl.): 112–117, 1978

  • Waal-Manning HJ, Simpson FO. Fenfluramine in obese patients on various antihypertensive drugs. Lancet 2: 1392–1395, 1969

    Article  PubMed  CAS  Google Scholar 

  • Wagner K, Neumayer H-H. Prevention of delayed graft function in cadaver kidney transplants by diltiazem. Lancet ii: 1355–1356, 1985

    Article  Google Scholar 

  • Waldorff S, Hansen PB, Egeblad A, Berning J, Buch J, et al. Interactions between digoxin and potassium-sparing diuretics. Clinical Pharmacology and Therapeutics 33: 418–423, 1983

    Article  PubMed  CAS  Google Scholar 

  • Walt R, Misiewicz G. Clinically important interactions involving drugs used in the treatment of peptic ulcer. In Petrie (Ed.) Clinically important adverse drug interactions, Vol. 3, Gastrointestinal, haematological and infectious disease therapy, pp. 21–37, Elsevier, Amsterdam, 1985

    Google Scholar 

  • Wassner SJ, Pennisi AJ, Malekzadeh MH, Fine RN. The adverse effect of anticonvulsant therapy on renal allograft survival. Journal of Paediatrics 88: 134–137, 1976

    Article  CAS  Google Scholar 

  • Watkins J, Abbot CE, Hensby CN, Webster J, Dollery CT. Attenuation of hypotensive effect of propranolol and thiazide diuretics by indomethacin. British Medical Journal 281: 702–703, 1980

    Article  PubMed  CAS  Google Scholar 

  • Webster J. Interactions of NSAIDs with diuretics and β-blockers: mechanisms and clinical implications. Drugs 30: 32–41, 1985

    Article  PubMed  CAS  Google Scholar 

  • Webster J, Newnham DM, Petrie JC. Initial dose of enalapril in hypertension. British Medical Journal 290: 1623–1624, 1985

    Article  PubMed  CAS  Google Scholar 

  • Weeks CE, Conard GJ, Kvam DC, Fox JM, Chang SF, et al. The effect of flucainide acetate, a new antiarrhythmic, on plasma digoxin levels. Journal of Clinical Pharmacology 26: 27–31, 1986

    PubMed  CAS  Google Scholar 

  • Weinberger M, Ginchansky E. Dose-dependent kinetics of theophylline disposition in asthmatic children. Journal of Paediatrics 91: 820–824, 1977

    Article  CAS  Google Scholar 

  • Weinberger M, Hudgel D, Spector S, Chidsey C. Inhibition of theophylline clearance by troleandomycin. Journal of Allergy and Clinical Immunology 59: 228–231, 1977

    Article  PubMed  CAS  Google Scholar 

  • Welling PC. Interactions affecting drug absorption. Clinical Pharmacokinetics 9: 404–434, 1984

    Article  PubMed  CAS  Google Scholar 

  • Werk EE, Choi Y, Sholiton L, Olinger C, Haque N. Interference in the effect of dexamethasone by diphenylhydantoin. New England Journal of Medicine 281: 32–34, 1969

    Article  PubMed  Google Scholar 

  • Werk EE, McGee J, Sholiton LJ. Effect of diphenylhydantoin on cortisol metabolism in man. Journal of Clinical Investigation 43: 1824–1835, 1964

    Article  PubMed  CAS  Google Scholar 

  • Wiles PG, Pyke DA. The chlorpropamide alcohol flush. Clinical Science 67: 375–381, 1984

    PubMed  CAS  Google Scholar 

  • Wong DG, Spence JD, Lamki L, Freeman D, McDonald JWD. Effect of non-steroidal anti-inflammatory drugs on control of hypertension by beta-blockers and diuretics. Lancet i: 997–1001, 1986

    Article  Google Scholar 

  • Wong YY, Ludden TM, Bell R. Effect of erythromycin on carbamazepine kinetics. Clinical Pharmacology and Therapeutics 33: 460–464, 1983

    Article  PubMed  CAS  Google Scholar 

  • Woosley RL, Nies AS, Guanethidine. New England Journal of Medicine 295: 1053–1057, 1976

    Article  PubMed  CAS  Google Scholar 

  • Wright AD, Barber SG, Kendall MJ, Poole PM. Beta-adrenoceptor-blocking drugs and blood sugar control in diabetes mellitus. British Medical Journal 1: 159–161, 1979

    Article  PubMed  CAS  Google Scholar 

  • Wright JM, Stokes EF, Sweeney VP. Isoniazid-induced carbamazepine toxicity and vice versa: a double drug interaction. New England Journal of Medicine 307: 1325–1327, 1982

    Article  PubMed  CAS  Google Scholar 

  • Wroblewski BA, Singer WD, Whyte J. Carbamazepine-erythromycin interaction: case studies and clinical significance. Journal of American Medical Association 255: 1165–1167, 1986

    Article  CAS  Google Scholar 

  • Yap V, Patch A, Thomsen J. Hyperkalaemia with cardiac arrhythmia: induction by salt substitutes, spironolactone and azotaemia. Journal of the American Medical Association 236: 2775–2776, 1976

    Article  PubMed  CAS  Google Scholar 

  • Yassa R. Lithium-methyldopa interaction. Canadian Medical Association Journal 134: 141–142, 1986

    PubMed  CAS  Google Scholar 

  • Ylitalo P, Pitkajarvi T, Pyykonen M-L, Nurmi A-K, Seppala G, et al. Inhibition of prostaglandin synthesis by indomethacin interests with antihypertensive effect of atenolol. Clinical Pharmacology and Therapeutics 38: 443–449, 1985

    Article  PubMed  CAS  Google Scholar 

  • Zazgornik VJ, Hruby K, Schmidt P, Kopsa H, Pilo P. Haemolysis after combined azathioprine-allopurinol therapy. Acta Medica Austria 6: 197–199, 1979

    CAS  Google Scholar 

  • Zilly W, Breimer DD, Richter E. Pharmacokinetic interactions with rifampicin. Clinical Pharmacokinetics 2: 61–70, 1977

    Article  PubMed  CAS  Google Scholar 

  • Zimm S, Collins JM, O’Neill D, Chabner BA, Poplack DG. Inhibition of first-pass metabolism in cancer chemotherapy: interaction of 6-mercaptopurine and allopurinol. Clinical Pharmacology and Therapeutics 34: 810–817, 1984

    Google Scholar 

  • Zuik M, Mandel M. Methotrexate-salicylate interaction: a clinical and experimental study. Surgery Forum 26: 567–569, 1975

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Clinical Pharmacology Unit, University Department of Medicine, Gardiner Institute, Western Infirmary, Glasgow, G11 6NT, Scotland

    Gordon T. McInnes &  Martin J. Brodie

Authors
  1. Gordon T. McInnes
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Martin J. Brodie
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

McInnes, G.T., Brodie, M.J. Drug Interactions that Matter. Drugs 36, 83–110 (1988). https://doi.org/10.2165/00003495-198836010-00006

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00003495-198836010-00006

Search

Navigation