Three Cases of Idiopathic Diffuse Pulmonary Ossification

Ryuya Edahiro; Hiroyuki Kurebe; Saeko Nakatsubo; Yuki Hosono; Nobuhiko Sawa; Kohei Nishida; Yuko Ohara; Yohei Oshitani; Hiroyuki Kagawa; Kazuyuki Tsujino; Kenji Yoshimura; Keisuke Miki; Mari Miki; Seigo Kitada; Masahide Mori

doi:10.2169/internalmedicine.0929-18

CASE REPORTS

Three Cases of Idiopathic Diffuse Pulmonary Ossification

Ryuya Edahiro, Hiroyuki Kurebe, Saeko Nakatsubo, Yuki Hosono, Nobuhiko Sawa, Kohei Nishida, Yuko Ohara, Yohei Oshitani, Hiroyuki Kagawa, Kazuyuki Tsujino, Kenji Yoshimura, Keisuke Miki, Mari Miki, Seigo Kitada, Masahide Mori

Author information

Ryuya Edahiro
Department of Respiratory Medicine, National Hospital Organization Toneyama National Hospital, Japan
Hiroyuki Kurebe
Department of Respiratory Medicine, National Hospital Organization Toneyama National Hospital, Japan
Saeko Nakatsubo
Department of Respiratory Medicine, National Hospital Organization Toneyama National Hospital, Japan
Yuki Hosono
Department of Respiratory Medicine, National Hospital Organization Toneyama National Hospital, Japan
Nobuhiko Sawa
Department of Respiratory Medicine, National Hospital Organization Toneyama National Hospital, Japan
Kohei Nishida
Department of Respiratory Medicine, National Hospital Organization Toneyama National Hospital, Japan
Yuko Ohara
Department of Respiratory Medicine, National Hospital Organization Toneyama National Hospital, Japan
Yohei Oshitani
Department of Respiratory Medicine, National Hospital Organization Toneyama National Hospital, Japan
Hiroyuki Kagawa
Department of Respiratory Medicine, National Hospital Organization Toneyama National Hospital, Japan
Kazuyuki Tsujino
Department of Respiratory Medicine, National Hospital Organization Toneyama National Hospital, Japan
Kenji Yoshimura
Department of Respiratory Medicine, National Hospital Organization Toneyama National Hospital, Japan
Keisuke Miki
Department of Respiratory Medicine, National Hospital Organization Toneyama National Hospital, Japan
Mari Miki
Department of Respiratory Medicine, National Hospital Organization Toneyama National Hospital, Japan
Seigo Kitada
Department of Respiratory Medicine, National Hospital Organization Toneyama National Hospital, Japan
Masahide Mori
Department of Respiratory Medicine, National Hospital Organization Toneyama National Hospital, Japan

Keywords: pulmonary ossification, ectopic bone formation, pneumothorax, diffuse lung disease

JOURNAL OPEN ACCESS

2019 Volume 58 Issue 4 Pages 545-551

DOI https://doi.org/10.2169/internalmedicine.0929-18

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Details

Abstract

Diffuse pulmonary ossification (DPO) is an uncommon diffuse lung disease characterized by metaplastic bone formation in the lung parenchyma and is rarely diagnosed in life. While DPO usually occurs as a secondary disease, idiopathic cases are extremely rare. We describe three cases of idiopathic DPO, two of which were definitively diagnosed by surgical lung biopsy. One case was observed in a 43-year-old man with a history of recurrent pneumothorax who developed pneumothorax after the surgical biopsy. Few reports have described cases of DPO with recurrent pneumothorax; however, pneumothorax should be considered as a potential complication when such patients are encountered.

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