Flavonols and Flavones – Protecting Against Myocardial Ischemia/ Reperfusion Injury by Targeting Protein Kinases

Title:Flavonols and Flavones – Protecting Against Myocardial Ischemia/ Reperfusion Injury by Targeting Protein Kinases

Volume: 25 Issue: 34

Author(s): Owen L. Woodman*, Kai Yee Chin, Colleen J. Thomas, Dominic C.H. Ng and Clive N. May

Affiliation:

• School of Health & Biomedical Sciences, RMIT University, Bundoora, Victoria,Australia

Keywords: Antioxidant, cardioprotection, ischemia-reperfusion, reactive oxygen species, flavone, flavonol, kinase.

Abstract: In acute myocardial infarction (AMI), the first line of treatment is to rapidly restore blood flow to the ischemic myocardium to limit infarct size. It is now well established that though clearly beneficial, the positive outcomes of this intervention are limited by injury in response to the reperfusion itself in addition to the prior ischemia. This process is described as reperfusion injury and is considered to contribute to the arrhythmias, microvascular dysfunction and impaired cardiac contractility that is observed even after the restoration of coronary blood flow. Thus an important, currently unmet, therapeutic challenge is to address the outcomes of this reperfusion injury. In this article, we review the evidence that flavonols and flavones may prove useful in preserving cardiac function after ischemia and reperfusion and consider the possible mechanisms, in particular, the inhibition of kinases, by which they may exert protection.

Cite this article as:

Woodman L. Owen *, Chin Yee Kai , Thomas J. Colleen , Ng C.H. Dominic and May N. Clive , Flavonols and Flavones – Protecting Against Myocardial Ischemia/ Reperfusion Injury by Targeting Protein Kinases, Current Medicinal Chemistry 2018; 25 (34) . https://dx.doi.org/10.2174/0929867325666180326161730