Abstract
The Myc family proteins are key regulators of animal growth and development. dMyc, the only Drosophila member of the Myc gene family, is orthologous to the mammalian c-Myc oncoprotein. Extensive studies have revealed much about both upstream regulators and downstream target genes in the sphere of Myc regulation. Here, we review some of the critical discoveries made using the Drosophila model, in particular those studies that have explored the essential role of the Myc family in growth and cell cycle progression and identified many of the upstream signals and downstream targets common to both c-Myc and dMyc.
Keywords: Myc, Drosophila, growth, cell cycle, ribosome biogenesis, stem cells, cell competition, cancer
Current Drug Targets
Title: Myc - What We have Learned from Flies
Volume: 10 Issue: 7
Author(s): N. A. Siddall, J. I. Lin, G. R. Hime and L. M. Quinn
Affiliation:
Keywords: Myc, Drosophila, growth, cell cycle, ribosome biogenesis, stem cells, cell competition, cancer
Abstract: The Myc family proteins are key regulators of animal growth and development. dMyc, the only Drosophila member of the Myc gene family, is orthologous to the mammalian c-Myc oncoprotein. Extensive studies have revealed much about both upstream regulators and downstream target genes in the sphere of Myc regulation. Here, we review some of the critical discoveries made using the Drosophila model, in particular those studies that have explored the essential role of the Myc family in growth and cell cycle progression and identified many of the upstream signals and downstream targets common to both c-Myc and dMyc.
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Cite this article as:
Siddall A. N., Lin I. J., Hime R. G. and Quinn M. L., Myc - What We have Learned from Flies, Current Drug Targets 2009; 10 (7) . https://dx.doi.org/10.2174/138945009788680400
DOI https://dx.doi.org/10.2174/138945009788680400 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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