Abstract
Antisense technology provides outstanding promise for treatment of human disease, having broad applicability and high specificity. Although advances have been made in antisense oligonucleotide chemistry, leading to increased plasma and cellular stability, and decreased toxicity, considerable potential remains for the enhancement of oligonucleotide uptake for targeted delivery of oligonucleotides. One promising avenue for achieving this is via linkage of antisense oligonucleotides to peptide carriers. This review looks at the current status of developments in this area.
Keywords: antisense therapy, oligonucleotides, nuclear localisation sequences
Mini-Reviews in Medicinal Chemistry
Title: Peptide-Oligonucleotide Hybrids in Antisense Therapy
Volume: 5 Issue: 1
Author(s): Tracie L. Pierce, Anthony R. White, Geoffrey W. Tregear and Patrick M. Sexton
Affiliation:
Keywords: antisense therapy, oligonucleotides, nuclear localisation sequences
Abstract: Antisense technology provides outstanding promise for treatment of human disease, having broad applicability and high specificity. Although advances have been made in antisense oligonucleotide chemistry, leading to increased plasma and cellular stability, and decreased toxicity, considerable potential remains for the enhancement of oligonucleotide uptake for targeted delivery of oligonucleotides. One promising avenue for achieving this is via linkage of antisense oligonucleotides to peptide carriers. This review looks at the current status of developments in this area.
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Pierce L. Tracie, White R. Anthony, Tregear W. Geoffrey and Sexton M. Patrick, Peptide-Oligonucleotide Hybrids in Antisense Therapy, Mini-Reviews in Medicinal Chemistry 2005; 5 (1) . https://dx.doi.org/10.2174/1389557053402846
DOI https://dx.doi.org/10.2174/1389557053402846 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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