Abstract
Thymidine Phosphorylase (TPase) catalyses the reversible phosphorolysis of pyrimidine 2- deoxynucleosides to 2-deoxyribose-1-phosphate and their respective pyrimidine bases, including the phosphorolysis of nucleoside analogues with important antiviral or anticancer properties. Moreover, TPase, identified also as the angiogenic platelet-derived endothelial cell growth factor (PD-ECGF), stimulates endothelial cell migration in vitro and angiogenesis in vivo and plays an important role in tumour progression and metastasis. Here we have summarized the most recent approaches in the search for novel TPase inhibitors together with the potential therapeutic applications of such inhibitors.
Keywords: Thymidine Phosphorylase, PD-ECGF, angiogenesis, nucleoside metabolism, anticancer drugs, Thymidine Phosphorylase Inhibitors, Inhibitor Design
Mini-Reviews in Medicinal Chemistry
Title: Thymidine Phosphorylase Inhibitors: Recent Developments and Potential Therapeutic Applications
Volume: 5 Issue: 12
Author(s): Maria-Jesus Perez-Perez, Eva-Maria Priego, Ana-Isabel Hernandez, Maria-Jose Camarasa, Jan Balzarini and Sandra Liekens
Affiliation:
Keywords: Thymidine Phosphorylase, PD-ECGF, angiogenesis, nucleoside metabolism, anticancer drugs, Thymidine Phosphorylase Inhibitors, Inhibitor Design
Abstract: Thymidine Phosphorylase (TPase) catalyses the reversible phosphorolysis of pyrimidine 2- deoxynucleosides to 2-deoxyribose-1-phosphate and their respective pyrimidine bases, including the phosphorolysis of nucleoside analogues with important antiviral or anticancer properties. Moreover, TPase, identified also as the angiogenic platelet-derived endothelial cell growth factor (PD-ECGF), stimulates endothelial cell migration in vitro and angiogenesis in vivo and plays an important role in tumour progression and metastasis. Here we have summarized the most recent approaches in the search for novel TPase inhibitors together with the potential therapeutic applications of such inhibitors.
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Cite this article as:
Perez-Perez Maria-Jesus, Priego Eva-Maria, Hernandez Ana-Isabel, Camarasa Maria-Jose, Balzarini Jan and Liekens Sandra, Thymidine Phosphorylase Inhibitors: Recent Developments and Potential Therapeutic Applications, Mini-Reviews in Medicinal Chemistry 2005; 5 (12) . https://dx.doi.org/10.2174/138955705774933301
DOI https://dx.doi.org/10.2174/138955705774933301 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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