Abstract
Association of proteins into homo- and hetero-oligomers plays an important role in a plethora of biological phenomena. Inhibition of these interactions is increasingly recognized as a valuable new direction in drug design. In this mini-review we consider inhibition of protein misfolding and aggregation, molecules that disrupt enzyme quaternary structure, and signaling inhibitors, as emerging drugs.
Keywords: Protein-protein interactions, inhibitor, amyloid, HIV, drug design, small molecule-protein interaction
Mini-Reviews in Medicinal Chemistry
Title: Inhibiting Protein-Protein Interactions as an Emerging Paradigm for Drug Discovery
Volume: 7 Issue: 2
Author(s): J. A. Gerrard, C. A. Hutton and M. A. Perugini
Affiliation:
Keywords: Protein-protein interactions, inhibitor, amyloid, HIV, drug design, small molecule-protein interaction
Abstract: Association of proteins into homo- and hetero-oligomers plays an important role in a plethora of biological phenomena. Inhibition of these interactions is increasingly recognized as a valuable new direction in drug design. In this mini-review we consider inhibition of protein misfolding and aggregation, molecules that disrupt enzyme quaternary structure, and signaling inhibitors, as emerging drugs.
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Cite this article as:
Gerrard A. J., Hutton A. C. and Perugini A. M., Inhibiting Protein-Protein Interactions as an Emerging Paradigm for Drug Discovery, Mini-Reviews in Medicinal Chemistry 2007; 7 (2) . https://dx.doi.org/10.2174/138955707779802561
DOI https://dx.doi.org/10.2174/138955707779802561 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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