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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

An Efficient Synthesis, Characterization, and Antimicrobial Activities of Organomercury (II) piperidine-N-thiohydrazide Complexes

Author(s): Rama Sharma*

Volume 19, Issue 12, 2022

Published on: 01 August, 2022

Page: [1077 - 1083] Pages: 7

DOI: 10.2174/1568026622666220516122705

Price: $65

Abstract

Aim: To synthesize and characterize organomercury complexes. Background: Organomercury complexes have reported for different antimicrobial activities.

Objectives: Synthesis of organomercury complexes with piperidine thiohydrazide ligand and characterization, applications.

Methods: Complexes were synthesized by modified reported methods. Spectral (IR, UV, 1HNMR) and TG/DTA analyses were used to characterize the generated complexes. For some of the complexes produced, chemical kinetic characteristics such as activation energy, order of reaction, heat of reaction,

and apparent activation entropy were determined. The antimicrobial activities were also reported. Results: In these synthesized complexes, the thiohydrazides act as bidentate ligands, coordinating through the thiol Sulphur and terminal nitrogen. Elemental and spectral data of the ligand and complexes show that the compounds are pure enough.

Conclusion: Every synthesized complex is diamagnetic in nature. The complexes have better antibacterial activities against Z. mobilis than E. coli, with A. niger > Cerveleria in case of antifungal activities.

Keywords: Entropy, elemental analysis, spectral analysis, thermal analysis, antibacterial antifungal, antimicrobial activities.

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