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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis, Characterization of Some New Five Membered Heterocycles Based on Imidazole Moiety and their Applications on Therapeutics

Author(s): V. S.V. Satyanarayana, A. Sivakumar and Asit Ranjan Ghosh

Volume 8, Issue 3, 2011

Page: [276 - 283] Pages: 8

DOI: 10.2174/157018011794578196

Price: $65

Abstract

Different imidazole derivatives were prepared by utilizing the intermediate 2-(2,4,5-triphenyl-1H-imidazol-1- yl)acetohydrazide (3) using microwave irradiation method besides the traditional ones. They were used for synthesis of some new derivatives of 2,5-disubstituted-1,3,4-oxadiazole, pyrazole, 2,5-dimethylpyrrole and nitrogen containing five membered rings. All the synthesized compounds were characterized by IR, 1H & 13C NMR and mass spectral data. The antibacterial, antifungal (MIC) and antioxidant activities were verified for all the synthesized compounds.

Keywords: 2-(2,4,5-triphenyl-1H-imidazol-1-yl)acetohydrazide, Five membered heterocycles, Microwave irradiation, Antibacterial activity, Antifungal activity, Antioxidant activity


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