Abstract
Different imidazole derivatives were prepared by utilizing the intermediate 2-(2,4,5-triphenyl-1H-imidazol-1- yl)acetohydrazide (3) using microwave irradiation method besides the traditional ones. They were used for synthesis of some new derivatives of 2,5-disubstituted-1,3,4-oxadiazole, pyrazole, 2,5-dimethylpyrrole and nitrogen containing five membered rings. All the synthesized compounds were characterized by IR, 1H & 13C NMR and mass spectral data. The antibacterial, antifungal (MIC) and antioxidant activities were verified for all the synthesized compounds.
Keywords: 2-(2,4,5-triphenyl-1H-imidazol-1-yl)acetohydrazide, Five membered heterocycles, Microwave irradiation, Antibacterial activity, Antifungal activity, Antioxidant activity
Letters in Drug Design & Discovery
Title: Synthesis, Characterization of Some New Five Membered Heterocycles Based on Imidazole Moiety and their Applications on Therapeutics
Volume: 8 Issue: 3
Author(s): V. S.V. Satyanarayana, A. Sivakumar and Asit Ranjan Ghosh
Affiliation:
Keywords: 2-(2,4,5-triphenyl-1H-imidazol-1-yl)acetohydrazide, Five membered heterocycles, Microwave irradiation, Antibacterial activity, Antifungal activity, Antioxidant activity
Abstract: Different imidazole derivatives were prepared by utilizing the intermediate 2-(2,4,5-triphenyl-1H-imidazol-1- yl)acetohydrazide (3) using microwave irradiation method besides the traditional ones. They were used for synthesis of some new derivatives of 2,5-disubstituted-1,3,4-oxadiazole, pyrazole, 2,5-dimethylpyrrole and nitrogen containing five membered rings. All the synthesized compounds were characterized by IR, 1H & 13C NMR and mass spectral data. The antibacterial, antifungal (MIC) and antioxidant activities were verified for all the synthesized compounds.
Export Options
About this article
Cite this article as:
S.V. Satyanarayana V., Sivakumar A. and Ranjan Ghosh Asit, Synthesis, Characterization of Some New Five Membered Heterocycles Based on Imidazole Moiety and their Applications on Therapeutics, Letters in Drug Design & Discovery 2011; 8 (3) . https://dx.doi.org/10.2174/157018011794578196
DOI https://dx.doi.org/10.2174/157018011794578196 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Safety and Efficacy of Duloxetine in the Treatment of Diabetic Peripheral Neuropathic Pain in Older Patients
Current Drug Safety The Tachykinergic System as Avenues for Drug Intervention
Recent Patents on CNS Drug Discovery (Discontinued) Advances in Development of Inhibitors of 17β-Hydroxysteroid Dehydrogenases
Anti-Cancer Agents in Medicinal Chemistry Cerebral Small Vessel Disease is Associated with Genetic Variations in CYP2J
Current Neurovascular Research Investigating Mitochondrial Dysfunction to Increase Drug Safety in the Pharmaceutical Industry
Current Drug Targets Gadd45 Proteins as Critical Signal Transducers Linking NF-κB to MAPK Cascades
Current Cancer Drug Targets How Stress Gets Under the Skin: Early Life Adversity and Glucocorticoid Receptor Epigenetic Regulation
Current Genomics Clinical Implication of Meissner’s Corpuscles
CNS & Neurological Disorders - Drug Targets Using Small Peptide Segments of Amyloid-β and Humanin to Examine their Physical Interactions
Protein & Peptide Letters The Making of a Portrait - Bringing it into Focus
Current Pharmaceutical Biotechnology Commentary: Gut Microbiota and Brain Function: A New Target for Brain Diseases?
CNS & Neurological Disorders - Drug Targets Phytotherapeutic and Natural Compound Applications for Age-Related, Inflammatory and Serious Eye Ailments
Current Molecular Pharmacology Impaired Quality Control of Mitochondria Underlying the Pathogenesis of Alzheimer's Disease
Current Drug Targets Recent Progress in Mutation-driven Therapy, Immunotherapy and Combination Therapy for the Treatment of Melanoma
Current Cancer Drug Targets Role of Free Radicals in Sepsis: Antioxidant Therapy
Current Pharmaceutical Design Passive Smoking, Endothelial Dysfunction and Related Markers in Healthy Individuals: An Update
Current Hypertension Reviews The Problem of Amino Acid Complementarity and Antisense Peptides
Current Protein & Peptide Science Scorpion Toxins Targeting Voltage-gated Sodium Channels Associated with Pain
Current Pharmaceutical Biotechnology Regulatory Mechanisms of Calcineurin Phosphatase Activity
Current Medicinal Chemistry Mannose Binding Lectin: A Potential Biomarker for Many Human Diseases
Current Medicinal Chemistry