Synthesis and Characterization of some Novel Quinoxaline-2, 3-Dione Derivatives: A Preliminary Investigation on their Activity Against a Human Epithelial Carcinoma Cell Line

Selvaraj      Jubie; Rajamanickam      Gayathri; Ammayappan      Rajam Srividya; Rajagopal      Kalirajan; Prabakaran      Prabitha; Sundaram      Sankar; Kannan      Elango

Abstract

Quinoxaline-2, 3-dione obtained from cyclocondensation reaction of o-phenylene diamine with oxalic acid, was reacted with chlorosulphonic acid under cold condition followed by a reaction with various benzimidazoles to give 2, 3- dioxo-1, 2, 3, 4-tetrahydroquinoxaline-6-sulphonyl benzimidazoles in satisfactory yield. Their structures were confirmed using 1H NMR, IR and mass analysis. Cytotoxicity of these derivatives were evaluated by growth inhibition of HEp-2 cells in vitro. The preliminary bioassay indicated that these compounds showed moderate cytotoxicity.

Keywords: Benzimidazole, Cytotoxicity, Quinoxaline-2,3-dione, SRB method, Electrophilic substitution, Human epithelial carcinoma cell line, Hetrocycles, Organic Synthesis, Antimalarial Activities, Benzimidazole Derivatives, Pharmacological Activities, Anthelminitic Agents, Veterinarian Medicine, Human Therapeutic Areas, Oxalic acid Dihydrate, Catalyst Microwave System