Abstract
A series of new biologically potent N-substitutedpyrazoline derivatives have been synthesized by reacting hydrazine hydrate and its derivatives with (2)-1-(4-chlorophenyl)-3-[4-(propan-2- yl)phenyl]prop-2-en-1-one, which in turn prepared by the base catalysed Claisen-Schmidt condensation reaction of 4-(propan-2-yl)benzaldehyde and 4-chloroacetophenone. All the synthesized compounds, 2a-e, 3a-d, 4a,b and 5a-c were screened for their in vitro antibacterial, antioxidant, antiproliferative properties and compounds 3b, 4b were evaluated for in vivo anti-inflammatory activity. The docking studies were carried out for these compounds against α-amylase with TREX1 (PDB:3B60) to predict their putative interactions. Some of the tested compounds showed significant antibacterial, antioxidant, antiproliferative, anti-inflammatory activity and molecular binding.
Keywords: Pyrazolines, antibacterial, antioxidant, antiproliferative, anti-inflammatory activity, molecular docking
Letters in Drug Design & Discovery
Title:Biologically Potent Pyrazoline Derivatives from Versatile (2)-1-(4- Chlorophenyl)-3-[4-(propan-2-yl)phenyl]prop-2-en-1-one
Volume: 14 Issue: 2
Author(s): Vinutha V. Salian, Badiadka Narayana, Balladka K. Sarojini, Enumadisetty S. Sindhupriya, Leelavathi N. Madhu and Shama Rao
Affiliation:
Keywords: Pyrazolines, antibacterial, antioxidant, antiproliferative, anti-inflammatory activity, molecular docking
Abstract: A series of new biologically potent N-substitutedpyrazoline derivatives have been synthesized by reacting hydrazine hydrate and its derivatives with (2)-1-(4-chlorophenyl)-3-[4-(propan-2- yl)phenyl]prop-2-en-1-one, which in turn prepared by the base catalysed Claisen-Schmidt condensation reaction of 4-(propan-2-yl)benzaldehyde and 4-chloroacetophenone. All the synthesized compounds, 2a-e, 3a-d, 4a,b and 5a-c were screened for their in vitro antibacterial, antioxidant, antiproliferative properties and compounds 3b, 4b were evaluated for in vivo anti-inflammatory activity. The docking studies were carried out for these compounds against α-amylase with TREX1 (PDB:3B60) to predict their putative interactions. Some of the tested compounds showed significant antibacterial, antioxidant, antiproliferative, anti-inflammatory activity and molecular binding.
Export Options
About this article
Cite this article as:
Salian V. Vinutha, Narayana Badiadka, Sarojini K. Balladka, Sindhupriya S. Enumadisetty, Madhu N. Leelavathi and Rao Shama, Biologically Potent Pyrazoline Derivatives from Versatile (2)-1-(4- Chlorophenyl)-3-[4-(propan-2-yl)phenyl]prop-2-en-1-one, Letters in Drug Design & Discovery 2017; 14 (2) . https://dx.doi.org/10.2174/1570180813666160519151723
DOI https://dx.doi.org/10.2174/1570180813666160519151723 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Antimitotic Potential of PARP Inhibitors, An Unexplored Therapeutic Alternative
Current Topics in Medicinal Chemistry Prospects for Inhibition of Lignin Degrading Enzymes to Control Ganoderma White Rot of Oil Palm
Current Enzyme Inhibition Chalcones Incorporated Pyrazole Ring Inhibit Proliferation, Cell Cycle Progression, Angiogenesis and Induce Apoptosis of MCF7 Cell Line
Anti-Cancer Agents in Medicinal Chemistry The Role of Neopterin in Atherogenesis and Cardiovascular Risk Assessment
Current Medicinal Chemistry Role of Asymmetric Dimethylarginine in Cardiorenal Syndrome
Current Pharmaceutical Design Stroke and Neuroinflamation: Role of Sexual Hormones
Current Pharmaceutical Design Discovery of Selective Probes and Antagonists for G Protein-Coupled Receptors FPR/FPRL1 and GPR30
Current Topics in Medicinal Chemistry In vitro Synthesis, Structure Elucidation, and Antioxidant Properties of Platinum(IV)-hydrazide Complexes: Molecular Modeling of Free- Hydrazides Suggested as Potent Lipoxygenase Inhibitor
Medicinal Chemistry A Review on CRISPR-mediated Epigenome Editing: A Future Directive for Therapeutic Management of Cancer
Current Drug Targets Use and Safety of Calcium Channel Blockers in Obstetrics
Current Medicinal Chemistry Forms of Iron Binding in the Cells and the Chemical Features of Chelation Therapy
Mini-Reviews in Medicinal Chemistry Adeno-associated Viral Vectors for Correction of Inborn Errors of Metabolism: Progressing Towards Clinical Application
Current Pharmaceutical Design New Molecular Targets in the Treatment of NSCLC
Current Pharmaceutical Design SYNTHESIS AND APPLICATIONS OF Fe3O4/SiO2 CORE-SHELL MATERIALS
Current Pharmaceutical Design Cancer Stem Cells Switch on Tumor Neovascularization
Current Molecular Medicine STAT3 as a Central Regulator of Tumor Metastases
Current Molecular Medicine Antioxidant Effects of Chalcones during the Inflammatory Response: An Overall Review
Current Medicinal Chemistry Regulatory Circuitries Coordinated by Transcription Factors and microRNAs at the Cornerstone of Hematopoietic Stem Cell Self-Renewal and Differentiation
Current Stem Cell Research & Therapy 1-Azaadamantanes: Pharmacological Applications and Synthetic Approaches
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Ocular Drug Delivery - New Strategies for Targeting Anterior and Posterior Segments of the Eye
Current Pharmaceutical Design