2-Aminoimidazoles from Leucetta Sponges: Synthesis and Biology of an Important Pharmacophore

Title: 2-Aminoimidazoles from Leucetta Sponges: Synthesis and Biology of an Important Pharmacophore

Volume: 5 Issue: 1

Author(s): J. D. Sullivan, R. L. Giles and R. E. Looper

Affiliation:

Keywords: Review, 2-aminoimidazole, synthesis, biological activity, natural products, naamine, naamidine, isonaamine, isonaamidine, Leucetta, Calcarea

Abstract: This review will focus on the ability of the 2-aminoimidazole to occupy a unique subset of chemical space which makes it an ideal pharmacophore for the development of small molecule collections for discovery based research. These observations rely both on the use of 2-aminoimidazoles as building blocks in medicinal chemistry as well as the recent discovery of alkaloids from sponges of the genus Leucetta which exhibit a diverse range of biological activities around a relatively limited structural core. The preparation of these compounds will also be highlighted.

Cite this article as:

Sullivan D. J., Giles L. R. and Looper E. R., 2-Aminoimidazoles from Leucetta Sponges: Synthesis and Biology of an Important Pharmacophore, Current Bioactive Compounds 2009; 5 (1) . https://dx.doi.org/10.2174/157340709787580892