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Review Article

Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicity of the Genus Nymphaea L.: A Review

Author(s): Boniface Pone Kamdem*, Eutrophe Le Doux Kamto, Aboubakar, Dieudonné Emmanuel Pegnyemb and Ferreira Elizabeth Igne

Volume 18, Issue 8, 2022

Published on: 10 March, 2022

Article ID: e110122200133 Pages: 39

DOI: 10.2174/1573407218666220111110352

Price: $65

Abstract

Background: Plants from the genus Nymphaea L. have been used for decades to treat various diseases, including dysentery, diarrhea, uterine cancer, gonorrhea, inflammation conditions, etc. The present study aims to critically analyze comprehensive literature on ethnopharmacological uses, phytochemistry, pharmacology, and toxicity of Nymphaea L.

Methods: The available information on Nymphaea L. was obtained from textbooks, theses, as well as published articles through libraries and electronic databases.

Results: More than 150 compounds, including flavonoids, phenolics, alkaloids, miscellaneous compounds, etc. were identified from Nymphaea L. extracts, and pure molecules from Nymphaea L. exhibited a wide range of pharmacological activities, including antimicrobial, anti-inflammatory, anticancer, immunomodulatory, hepatoprotective, antioxidant, cytotoxic, etc.

Conclusion: According to in vitro and in vivo studies, Nymphaea sp. are very promising medicinal plants. However, more in vivo experiments, cytotoxicity tests, and detailed mechanisms of action of their extracts and compounds are recommended to translate their ethnomedicinal claims into scientific rationale-based information.

Keywords: Drug discovery, ethnomedicine, Nymphaea L., pharmacology, phytochemistry, secondary metabolites.

Graphical Abstract

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