Abstract
Coronaviruses are important human and animal pathogens of the order Nidovirales. Several new members were discovered following the emergence of SARS-CoV in human populations, including two human coronaviruses and several animal coronaviruses. They cause respiratory and gastrointestinal illnesses and have been found in the brains of patients with multiple sclerosis. The high mortality of SARS, the identification of a natural reservoir, and the well-founded fear of provoking antibody-enhanced disease as a result of vaccination fueled the ongoing efforts in anti-coronavirus drug discovery. This review presents the results of current research.
Keywords: Coronavirus, SARS-CoV, Severe acute respiratory syndrome, SARS, main protease, 3CLpro, polymerase, helicase, interferon, interferon-inducer
Infectious Disorders - Drug Targets
Title: Drug Targets in Severe Acute Respiratory Syndrome (SARS) Virus and other Coronavirus Infections
Volume: 9 Issue: 2
Author(s): Tommy R. Tong
Affiliation:
Keywords: Coronavirus, SARS-CoV, Severe acute respiratory syndrome, SARS, main protease, 3CLpro, polymerase, helicase, interferon, interferon-inducer
Abstract: Coronaviruses are important human and animal pathogens of the order Nidovirales. Several new members were discovered following the emergence of SARS-CoV in human populations, including two human coronaviruses and several animal coronaviruses. They cause respiratory and gastrointestinal illnesses and have been found in the brains of patients with multiple sclerosis. The high mortality of SARS, the identification of a natural reservoir, and the well-founded fear of provoking antibody-enhanced disease as a result of vaccination fueled the ongoing efforts in anti-coronavirus drug discovery. This review presents the results of current research.
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Cite this article as:
Tong R. Tommy, Drug Targets in Severe Acute Respiratory Syndrome (SARS) Virus and other Coronavirus Infections, Infectious Disorders - Drug Targets 2009; 9 (2) . https://dx.doi.org/10.2174/187152609787847659
DOI https://dx.doi.org/10.2174/187152609787847659 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
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