Abstract
This review provides a short overview of the most significant biologically oriented theories of human personality. Personality concepts of Eysenck, Gray and McNaughton, Cloninger and Panksepp will be introduced and the focal evidence for the heritability of personality will be summarized. In this context, a synopsis of a large number of COMT genetic association studies (with a focus on the COMT Val158Met polymorphism) in the framework of the introduced biologically oriented personality theories will be given. In line with the theory of a continuum model between healthy anxious behavior and related psychopathological behavior, the role of the COMT gene in anxiety disorders will be discussed. A final outlook considers new research strategies such as genetic imaging and epigenetics for a better understanding of human personality.
Keywords: COMT Val158Met, personality, genetic imaging, anxiety, anxiety disorders, catechol-o-methyltransferase, dopamine, Eysenck's personality theory, Behavioral Inhibition system, Fight flight freezing system, Panksepp's personality theory
CNS & Neurological Disorders - Drug Targets
Title:The Role of the Catechol-O-Methyltransferase (COMT) Gene in Personality and Related Psychopathological Disorders
Volume: 11 Issue: 3
Author(s): Christian Montag, Magdalena Jurkiewicz and Martin Reuter
Affiliation:
Keywords: COMT Val158Met, personality, genetic imaging, anxiety, anxiety disorders, catechol-o-methyltransferase, dopamine, Eysenck's personality theory, Behavioral Inhibition system, Fight flight freezing system, Panksepp's personality theory
Abstract: This review provides a short overview of the most significant biologically oriented theories of human personality. Personality concepts of Eysenck, Gray and McNaughton, Cloninger and Panksepp will be introduced and the focal evidence for the heritability of personality will be summarized. In this context, a synopsis of a large number of COMT genetic association studies (with a focus on the COMT Val158Met polymorphism) in the framework of the introduced biologically oriented personality theories will be given. In line with the theory of a continuum model between healthy anxious behavior and related psychopathological behavior, the role of the COMT gene in anxiety disorders will be discussed. A final outlook considers new research strategies such as genetic imaging and epigenetics for a better understanding of human personality.
Export Options
About this article
Cite this article as:
Montag Christian, Jurkiewicz Magdalena and Reuter Martin, The Role of the Catechol-O-Methyltransferase (COMT) Gene in Personality and Related Psychopathological Disorders, CNS & Neurological Disorders - Drug Targets 2012; 11 (3) . https://dx.doi.org/10.2174/187152712800672382
DOI https://dx.doi.org/10.2174/187152712800672382 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
Call for Papers in Thematic Issues
Diagnosis and treatment of central nervous system infectious diseases
Infectious diseases of the central nervous system (CNS) can be divided into bacterial, tuberculous, viral, fungal, parasitic infections, etc. Early etiological treatment is often the most crucial means to reduce the mortality rate of patients with central nervous system infections, reduce complications and sequelae, and improve prognosis. The initial clinical ...read more
Techniques of Drug Repurposing: Delivering a new life to Herbs & Drugs
Of late, with the adaptation of innovative approaches and integration of advancements made towards medical sciences as well as the availability of a wide range of tools; several therapeutic challenges are being translated into viable clinical solutions, with a high degree of efficacy, safety, and selectivity. With a better understanding ...read more
Trends and perspectives in the rational management of CNS disorders
Central nervous system (CNS) diseases enforce a significant global health burden, driving ongoing efforts to improve our understanding and effectiveness of therapy. This issue investigates current advances in the discipline, focusing on the understanding as well as therapeutic handling of various CNS diseases. The issue covers a variety of diseases, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Subject Index to Volume 5
Current Protein & Peptide Science Novel Biomarkers for Lupus Nephritis in the “OMICS” Era
Current Medicinal Chemistry Biochemical and Therapeutic Effects of Antioxidants in the Treatment of Alzheimers Disease, Parkinsons Disease, and Amyotrophic Lateral Sclerosis
Current Drug Targets - CNS & Neurological Disorders Current Status and Future Prospective of Immunointervention in Multiple Sclerosis
Current Medicinal Chemistry Alzheimers Disease Drug Development in 2008 and Beyond: Problems and Opportunities
Current Alzheimer Research Effects of Biologic Agents and Other Disease-Modifying Antirheumatic Drugs on Cardiovascular Outcomes in Psoriasis and Psoriatic Arthritis: A Systematic Review
Current Pharmaceutical Design Galanin Receptor/Neuropeptide Y Receptor Interactions in the Central Nervous System
Current Protein & Peptide Science A Review of Mechanical Seals Heat Transfer Augmentation Techniques
Recent Patents on Mechanical Engineering A ‘Cosmopolis’ as the Foundation for Understanding Cultural Differences
Neuroscience and Biomedical Engineering (Discontinued) Molecular Genetics of Early- and Late-Onset Alzheimer’s Disease
Current Gene Therapy Measurement of myo-Inositol in Biological Systems by Mass Spectrometric and In Vivo 1H Magnetic Resonance Spectroscopic Techniques
Current Organic Chemistry Novel Pharmacological Targets for Cannabinoids
Current Neuropharmacology Substance P and Alzheimer’s Disease: Emerging Novel Roles
Current Alzheimer Research Proteome and Metabolome Alterations in Heart and Liver Indicate Compromised Energy Production During Sepsis
Protein & Peptide Letters Unfolded Protein Response and PERK Kinase as a New Therapeutic Target in the Pathogenesis of Alzheimer’s Disease
Current Medicinal Chemistry First Synthesis of 5- and 7-Phenylethynyl-8-hydroxyquinolines by Sonogashira Reaction
Letters in Organic Chemistry Experimental Strategies in Autoimmunity: Antagonists of Cytokines and their Receptors, Nanocarriers, Inhibitors of Immunoproteasome, Leukocyte Migration and Protein Kinases
Current Pharmaceutical Design Regulation of Endothelial Cell Death and Its Role in Angiogenesis and Vascular Regression
Current Neurovascular Research Suppression of TLR Signaling by Targeting TIR domain-Containing Proteins
Current Protein & Peptide Science Methods for Quantitation and Clustering of Gene Expression Data
Current Genomics