Association of epilepsy and comorbid conditions

Papers of special note have been highlighted as: ▪ of interest ▪▪ of considerable interest

Bibliography

• 1  Gaitatzis A, Carroll K, Majeed A, Sander WJ: The epidemiology of the comorbidity of epilepsy in the general population. Epilepsia45,1613–1622 (2004).▪ Only identified epidemiological study to use a medical database to identify comorbidities using a large sample size.
  MedlineGoogle Scholar
• 2  Tellez-Zenteno JF, Matijevic S, Wiebe S: Somatic comorbidity of epilepsy in the general population in Canada. Epilepsia46,1955–1962 (2005).
  MedlineGoogle Scholar
• 3  Bazil CW: Comprehensive care of the epilepsy patient – control, comorbidity, and cost. Epilepsia45,3–12 (2004).
  MedlineGoogle Scholar
• 4  Pulsipher DT, Seidenberg M, Jones J, Hermann B: Quality of life and comorbid medical and psychiatric conditions in temporal lobe epilepsy. Epilepsy Behav.9,510–514 (2006).
  MedlineGoogle Scholar
• 5  Wiebe S, Hesdorffer DC: Epilepsy: being ill in more ways than one. Epilepsy Curr.7,145–148 (2007).
  MedlineGoogle Scholar
• 6  Boro A, Haut S: Medical comorbidities in the treatment of epilepsy. Epilepsy Behav.4,S2–S12 (2003).
  MedlineGoogle Scholar
• 7  Forsgren L: Prevalence of epilepsy in adults in northern Sweden. Epilepsia33,450–458 (1992).
  Medline CASGoogle Scholar
• 8  Gaitatzis A, Trimble MR, Sander JW: The psychiatric comorbidity of epilepsy. Acta Neurol. Scand.110,207–220 (2004).
  Medline CASGoogle Scholar
• 9  Jalava M, Sillanpaa M: Concurrent illnesses in adults with childhood-onset epilepsy: a population-based 35-year follow-up study. Epilepsia37,1155–1163 (1996).
  Medline CASGoogle Scholar
• 10  Kobau R, Zahran H, Thurman DJ et al.: Epilepsy surveillance among adults – 19 states, behavioral risk factor surveillance system. MMWR Surveill. Summ.57(6),1–20 (2008).
  MedlineGoogle Scholar
• 11  Strine TW, Kobau R, Chapman DP et al.: Psychological distress, comorbidities, and health behaviors among U.S. adults with seizures: results from the 2002 National Health Interview Survey. Epilepsia46,1133–1139 (2005).
  MedlineGoogle Scholar
• 12  Davies S, Heyman I, Goodman R: A population survey of mental health problems in children with epilepsy. Dev. Med. Child Neurol.45,292–295 (2003).
  MedlineGoogle Scholar
• 13  Kobau R, Gilliam F, Thurman DJ: Prevalence of self-reported epilepsy or seizure disorder and its associations with self-reported depression and anxiety: results from the 2004 Healthstyles Survey. Epilepsia47,1915–1921 (2006).
  MedlineGoogle Scholar
• 14  Tellez-Zenteno JF, Patten SB, Jette N, Williams J, Wiebe S: Psychiatric comorbidity in epilepsy: a population-based analysis. Epilepsia48,2336–2344 (2007).
  MedlineGoogle Scholar
• 15  van Blarikom W, Tan IY, Aldenkamp AP, van Gennep ATG: Epilepsy, intellectual disability, and living environment: a critical review. Epilepsy Behav.9,14–18 (2006).
  MedlineGoogle Scholar
• 16  Jetter GM, Cavazos JE: Epilepsy in the elderly. Semin. Neurol.28,336–341 (2008).
  MedlineGoogle Scholar
• 17  Souverein PC, Webb DJ, Weil JG, Van Staa TP, Egberts ACG: Use of antiepileptic drugs and risk of fractures: case–control study among patients with epilepsy. Neurology66,1318–1324 (2006).
  Medline CASGoogle Scholar
• 18  Vestergaard P: Epilepsy, osteoporosis and fracture risk – a meta-analysis. Acta Neurol. Scand.112,277–286 (2005).▪ Detailed meta-analytic study examining bone health problems in epilepsy and discussion of possible mechanisms.
  Medline CASGoogle Scholar
• 19  Lado F, Spiegel R, Masur JH, Boro A, Haut SR: Value of routine screening for bone demineralization in an urban population of patients with epilepsy. Epilepsy Res.78,155–160 (2008).
  MedlineGoogle Scholar
• 20  Elliott JO, Lu B, Moore JL, McAuley JW, Long L: Exercise, diet, health behaviors, and risk factors among persons with epilepsy based on the California Health Interview Survey, 2005. Epilepsy Behav.13,307–315 (2008).
  MedlineGoogle Scholar
• 21  Rowan AJ: Common morbidities influence development, treatment strategies, and expected outcomes. Geriatrics60,30–34 (2005).
  MedlineGoogle Scholar
• 22  Bladin CF, Alexandrov AV, Bellavance A et al.: Seizures after stroke: a prospective multicenter study. Arch. Neurol.57,1617–1622 (2000).
  Medline CASGoogle Scholar
• 23  So EL, Annegers JF, Hauser WA, O’Brien PC, Whisnant JP: Population-based study of seizure disorders after cerebral infarction. Neurology46,350–355 (1996).
  Medline CASGoogle Scholar
• 24  Kotila M, Waltimo O: Epilepsy after stroke. Epilepsia33,495–498 (1992).
  Medline CASGoogle Scholar
• 25  Cordonnier C, Henon H, Derambure P, Pasquier F, Leys D: Influence of pre-existing dementia on the risk of post-stroke epileptic seizures. J. Neurol. Neurosurg. Psychiatry76,1649–1653 (2005).
  Medline CASGoogle Scholar
• 26  LaFrance WC, Kanner AM, Hermann B: Psychiatric comorbidities in epilepsy. Int. Rev. Neurobiol.83,347–383 (2008).▪▪ Extensive and comprehensive review of all psychiatric comorbidities in epilepsy.
  MedlineGoogle Scholar
• 27  Schmitz B: Depression and mania in patients with epilepsy. Epilepsia46,45–49 (2005).
  MedlineGoogle Scholar
• 28  Hermann BP, Seidenberg M, Haltiner A, Wyler AR: Mood state in unilateral temporal lobe epilepsy. Biol. Psychiatry30,1205–1218 (1991).
  Medline CASGoogle Scholar
• 29  Austin JK, Caplan R: Behavioral and psychiatric comorbidities in pediatric epilepsy: toward an integrative model. Epilepsia48,1639–1651 (2007).▪▪ Comprehensive review of psychological factors and proposal of an integrative model that combines biological factors.
  MedlineGoogle Scholar
• 30  Hesdorffer DC, Hauser WA, Annegers JF, Cascino G: Major depression is a risk factor for seizures in older adults. Ann. Neurol.47,246–249 (2000).
  Medline CASGoogle Scholar
• 31  Ekinci O, Titus JB, Rodopman AA, Berkem M, Trevathan E: Depression and anxiety in children and adolescents with epilepsy: prevalence, risk factors, and treatment. Epilepsy Behav.14,8–18 (2009).
  MedlineGoogle Scholar
• 32  Jones JE, Watson R, Sheth R et al.: Psychiatric comorbidity in children with new onset epilepsy. Dev. Med. Child Neurol.49,493–497 (2007).
  MedlineGoogle Scholar
• 33  Kanner AM: Depression in epilepsy: prevalence, clinical semiology, pathogenic mechanisms, and treatment. Biol. Psychiatry54,388–398 (2003).▪▪ Detailed review of presentation of depression in epilepsy, risk factors and mechanisms.
  MedlineGoogle Scholar
• 34  Kanner AM: Epilepsy and mood disorders. Epilepsia48,20–22 (2007).
  MedlineGoogle Scholar
• 35  Rosche J, Uhlmann C, Froscher W: Low serum folate levels as a risk factor for depressive mood in patients with chronic epilepsy. J. Neuropsychiatry Clin. Neurosci.15,64–66 (2003).
  MedlineGoogle Scholar
• 36  Ludvigsson P, Hesdorffer D, Olafsson E, Kjartansson O, Hauser WA: Migraine with aura is a risk factor for unprovoked seizures in children. Ann. Neurol.59,210–213 (2006).
  MedlineGoogle Scholar
• 37  Bigal ME, Lipton RB, Cohen J, Silberstein SD: Epilepsy and migraine. Epilepsy Behav.4(Suppl. 2),S13–S24 (2003).
  MedlineGoogle Scholar
• 38  Scher AI, Bigal ME, Lipton RB: Comorbidity of migraine. Curr. Opin. Neurol.18,305–310 (2005).
  MedlineGoogle Scholar
• 39  Calabresi P, Galletti F, Rossi C, Sarchielli P, Cupini LM: Antiepileptic drugs in migraine: from clinical aspects to cellular mechanisms. Trends Pharmacol. Sci.28,188–195 (2007).
  Medline CASGoogle Scholar
• 40  Gorji A: Spreading depression: a review of the clinical relevance. Brain Res. Brain Res. Rev.38,33–60 (2001).▪▪ Most extensive review of cortical spreading depression in migraine to date.
  Medline CASGoogle Scholar
• 41  Rogawski MA: Common pathophysiologic mechanisms in migraine and epilepsy. Arch. Neurol.65,709–714 (2008).
  MedlineGoogle Scholar
• 42  Gargus JJ: Genetic calcium signaling abnormalities in the central nervous system: seizures, migraine, and autism. Ann. NY Acad. Sci.1151,133–156 (2009).
  Medline CASGoogle Scholar
• 43  Crompton DE, Berkovic SF: The borderland of epilepsy: clinical and molecular features of phenomena that mimic epileptic seizures. Lancet Neurol.8,370–381 (2009).
  Medline CASGoogle Scholar
• 44  Ounsted C: The hyperkinetic syndrome in epileptic children. Lancet269,303–311 (1955).
  Medline CASGoogle Scholar
• 45  Elliott JO, Lu B, Shneker B, Charyton C, Moore JL: Comorbidity, health screening, and quality of life among persons with a history of epilepsy. Epilepsy Behav.14,125–129 (2009).
  MedlineGoogle Scholar
• 46  Hesdorffer DC, Ludvigsson P, Olafsson E, Gudmundsson G, Kjartansson O, Hauser WA: ADHD as a risk factor for incident unprovoked seizures and epilepsy in children. Arch. Gen. Psychiatry61,731–736 (2004).
  MedlineGoogle Scholar
• 47  Dunn DW, Austin JK, Harezlak J, Ambrosius WT: ADHD and epilepsy in childhood. Dev. Med. Child Neurol.45,50–54 (2003).
  MedlineGoogle Scholar
• 48  Hermann B, Jones J, Dabbs K et al.: The frequency, complications and aetiology of ADHD in new onset paediatric epilepsy. Brain130,3135–3148 (2007).
  MedlineGoogle Scholar
• 49  Sherman EM, Slick DJ, Connolly MB, Eyrl KL: ADHD, neurological correlates and health-related quality of life in severe pediatric epilepsy. Epilepsia48,1083–1091 (2007).
  MedlineGoogle Scholar
• 50  McIntyre DC, Gilby KL: Genetically seizure-prone or seizure-resistant phenotypes and their associated behavioral comorbidities. Epilepsia48(Suppl. 9),30–32 (2007).
  MedlineGoogle Scholar
• 51  Hermann B, Seidenberg M, Sager M et al.: Growing up with epilepsy: the neglected issue of cognitive and brain health in aging and elder persons with chronic epilepsy. Epilepsia49,731–740 (2008).
  MedlineGoogle Scholar
• 52  Levisohn PM: The autism–epilepsy connection. Epilepsia48(Suppl. 9),33–35 (2007).
  MedlineGoogle Scholar