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Research Article

Apitherapeutics and phage-loaded nanofibers as wound dressings with enhanced wound healing and antibacterial activity

    Wessam A Sarhan

    Department of Chemistry, School of Sciences & Engineering, The American University in Cairo, New Cairo 11835, Egypt

    &
    Hassan ME Azzazy

    *Author for correspondence: Tel.: +202 2615 2559; Fax: +202 2795 7565;

    E-mail Address: hazzazy@aucegypt.edu

    Department of Chemistry, School of Sciences & Engineering, The American University in Cairo, New Cairo 11835, Egypt

    Published Online:https://doi.org/10.2217/nnm-2017-0151

    Aim: Develop green wound dressings which exhibit enhanced wound-healing ability and potent antibacterial effects. Methods: Honey, polyvinyl alcohol, chitosan nanofibers were electrospun and loaded with bee venom, propolis and/or bacteriophage against the multidrug-resistant Pseudomonas aeruginosa and examined for their antibacterial, wound-healing ability and cytotoxicity. Results: Among different formulations of nanofibers, honey, polyvinyl alcohol, chitosan-bee venom/bacteriophage exhibited the most potent antibacterial activity against all tested bacterial strains (Gram-positive and -negative strains) and achieved nearly complete killing of multidrug-resistant P. aeruginosa. In vivo testing revealed enhanced wound-healing results and cytotoxicity testing proved improved biocompatibility. Conclusion: The developed biocompatible nanofibers represent competitive wound-healing dressings with potent antibacterial and wound-healing activity.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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