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Research Article

Mesoporous silica-coated bismuth nanohybrids as a new platform for photoacoustic/computed tomography imaging and synergistic chemophotothermal therapy

    Zhenglin Li

    State Key Laboratory of Urban Water Resource & Environment, School of Chemistry & Chemical Engineering, Harbin Institute of Technology, Harbin 150001, PR China

    Condensed Matter Science & Technology Institute, Harbin Institute of Technology, Harbin 150001, PR China

    Authors contributed equally

    Search for more papers by this author

    ,
    Xuelei Fan

    State Key Laboratory of Urban Water Resource & Environment, School of Chemistry & Chemical Engineering, Harbin Institute of Technology, Harbin 150001, PR China

    Authors contributed equally

    Search for more papers by this author

    ,
    Jing Liu

    National Centre for Nanoscience & Technology, Chinese Academy of Sciences, Beijing 100190, PR China

    ,
    Ying Hu

    School of Life Science & Technology, Harbin Institute of Technology, Harbin 150001, PR China

    ,
    Yingwei Yang

    College of Chemistry, Jilin University, Changchun 130012, PR China

    ,
    Zhuo Li

    State Key Laboratory of Urban Water Resource & Environment, School of Chemistry & Chemical Engineering, Harbin Institute of Technology, Harbin 150001, PR China

    ,
    Ye Sun

    Condensed Matter Science & Technology Institute, Harbin Institute of Technology, Harbin 150001, PR China

    ,
    Chunying Chen

    National Centre for Nanoscience & Technology, Chinese Academy of Sciences, Beijing 100190, PR China

    &
    Miao Yu

    *Author for correspondence:

    E-mail Address: miaoyu_che@hit.edu.cn

    State Key Laboratory of Urban Water Resource & Environment, School of Chemistry & Chemical Engineering, Harbin Institute of Technology, Harbin 150001, PR China

    Published Online:https://doi.org/10.2217/nnm-2018-0106

    Aim: Polyethylene glycol modified mesoporous silica-coated bismuth nanohybrids (Bi@mSiO2-PEG) are fabricated for chemothermotherapy and multimodal imaging. Materials & methods: The Bi@mSiO2-PEG are synthesized by coating mesoporous SiO2 onto metallic Bi cores, followed by PEG modification. Their cytotoxicity, photothermal effect, drug loading, antitumor effect and imaging abilities are evaluated. Results: The nanohybrids show good biocompatibility, strong near-infrared absorbance, high photothermal conversion efficiency (∼36.6%), prominent infrared thermal imaging and photothermal killing efficacy on cancer cells. Utilizing the nanohybrids as potent drug carriers, a synergistic antitumor effect through chemothermotherapy is realized. Thanks to the superhigh x-ray attenuation coefficient and strong photothermal ability, high-contrast photoacoustic and x-ray computed tomography imaging are achieved. Conclusion: These results reveal great potentials of the Bi@mSiO2-PEG for precise and efficient anticancer treatments.

    Papers of special note have been highlighted as: • of interest; ••of considerable interest

    References

    • 1 Donaldson KL, Goolsby GL, Wahl AF. Cytotoxicity of the anticancer agents cisplatin and taxol during cell proliferation and the cell cycle. Int. J. Cancer 57(6), 847–855 (1994).
    • 2 Kouranos V, Dimopoulos G, Vassias A, Syrigos AN. Chemotherapy-induced neutropenia in lung cancer patients: the role of antibiotic prophylaxis. Cancer Lett. 313(1), 9–14 (2011).
    • 3 Kintzel PE, Dorr RT. Anticancer drug renal toxicity and elimination: dosing guidelines for altered renal function. Cancer Treat. Rev. 21(1), 33–64 (1995).
    • 4 Szakács G, Paterson JK, Ludwig JA, Booth-Genthe C, Gottesman MM. Targeting multidrug resistance in cancer. Nat. Rev. Drug Discov. 5(3), 219–234 (2006).
    • 5 Torchilin VP. Recent advances with liposomes as pharmaceutical carriers. Nat. Rev. Drug Discov. 4(2), 145–160 (2005).
    • 6 Jing L, Liang X, Li X, Yang Y, Dai Z. Covalent attachment of Mn-porphyrin onto doxorubicin-loaded poly(lactic acid) nanoparticles for potential magnetic resonance imaging and pH-sensitive drug delivery. Acta Biomater. 9(12), 9434–9441 (2013).
    • 7 Song G, Wang Q, Wang Y et al. Nanocomposites: a low-toxic multifunctional nanoplatform based on Cu9S5@mSiO2 core-shell nanocomposites: combining photothermal- and chemotherapies with infrared thermal imaging for cancer treatment. Adv. Funct. Mater. 23(35), 4281–4292 (2013). • Illustrates a successful example of mSiO2 based nanoparticles for chemophotothermal synergistic therapy.
    • 8 Tang J, Kong B, Wu H et al. Carbon nanodots featuring efficient FRET for real-time monitoring of drug delivery and two-photon imaging. Adv. Mater. 25(45), 6569–6574 (2013).
    • 9 Zheng T, Li GG, Zhou F, Wu R, Zhu JJ, Wang H. Gold-nanosponge-based multistimuli-responsive drug vehicles for targeted chemo-photothermal therapy. Adv. Mater. 28(37), 8218–8226 (2016).
    • 10 Song N, Yang YW. Molecular and supramolecular switches on mesoporous silica nanoparticles. Chem. Soc. Rev. 44(11), 3474–3504 (2015). • Summarizes recent advances related to the therapeutic use of mesoporous silica nanoparticles.
    • 11 Wu M, Wang X, Yang Y. Polymer Nanoassembly as delivery systems and anti-bacterial toolbox: from PGMAs to MSN@PGMAs. Chem. Rec. 18(1), 45–54 (2018).
    • 12 Yang Y, Sun Y, Song N. Switchable host–guest systems on surfaces. Acc. Chem. Res. 47(7), 1950–1960 (2014).
    • 13 Li Z, Yang YW. Creation and bioapplications of porous organic polymer materials. J. Mater. Chem. B 5(47), 9278–9290 (2017).
    • 14 Fang J, Nakamura H, Maeda H. The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Adv. Drug Deliver. Rev. 63(3), 136–151 (2011).
    • 15 He Q, Shi J. MSN anti-cancer nanomedicines: chemotherapy enhancement, overcoming of drug resistance, and metastasis inhibition. Adv. Mater. 26(3), 391–411 (2014).
    • 16 Yang P, Gai S, Lin J. Functionalized mesoporous silica materials for controlled drug delivery. Chem. Soc. Rev. 41(9), 3679–3698 (2012). •• Demonstrates how to synthesize functionalized mesoporous silica nanoparticles.
    • 17 Zhu YF, Shi JL, Li YS, Chen HR, Shen WH, Dong XP. Storage and release of ibuprofen drug molecules in hollow mesoporous silica spheres with modified pore surface. Micropor. Mesopor. Mat. 85(1), 75–81 (2005).
    • 18 Yang J, Zhang F, Chen Y et al. Core-shell Ag@SiO2@mSiO2 mesoporous nanocarriers for metal-enhanced fluorescence. Chem. Commun. 47(42), 11618–11620 (2011).
    • 19 Li QL, Sun Y, Sun YL et al. Mesoporous silica nanoparticles coated by layer-by-layer self-assembly using cucurbit [7]uril for in vitro and in vivo anticancer drug release. Chem. Mater. 26(22), 6418–6431 (2014).
    • 20 Li Z, Barnes JC, Bosoy A, Stoddart JF, Zink JI. Mesoporous silica nanoparticles in biomedical applications. Chem. Soc. Rev. 41(7), 2590–2605 (2012).
    • 21 Yang Y. Towards biocompatible nanovalves based on mesoporous silica nanoparticles. Med. Chem. Commun. 2(11), 1033–1049 (2011).
    • 22 Zhou H, Wang X, Tang J, Yang Y. Tuning the growth, crosslinking, and gating effect of disulfide-containing PGMAs on the surfaces of mesoporous silica nanoparticles for redox/pH dual-controlled cargo release. Polym. Chem. 7(12), 2171–2179 (2016).
    • 23 Li Q, Xu S, Zhou H et al. pH and glutathione dual-responsive dynamic cross-linked supramolecular network on mesoporous silica nanoparticles for controlled anticancer drug-release. ACS Appl. Mater. Interfaces 7(51), 28656–28664 (2015).
    • 24 Li H, Tan L, Jia P et al. Near-infrared light-responsive supramolecular nanovalve based on mesoporous silica–coated gold nanorods. Chem. Sci. 5(7), 2804–2808 (2014).
    • 25 Song G, Chao Y, Chen Y et al. All-in-one theranostic nanoplatform based on hollow TaOx for chelator-free labeling imaging, drug delivery, and synergistically enhanced radiotherapy. Adv. Funct. Mater. 26(45), 8243–8254 (2016).
    • 26 Li Z, Liu J, Hu Y et al. Multimodal imaging-guided antitumor photothermal therapy and drug delivery using bismuth selenide spherical-sponge. ACS Nano 10(10), 9646–9658 (2016). •• Illustrates a successful example of Bi nanoparticles for chemophotothermal synergistic therapy.
    • 27 Li Z, Hu Y, Jiang T et al. Human-serum-albumin-coated prussian blue nanoparticles as pH-/thermotriggered drug-delivery vehicles for cancer thermochemotherapy. Part. Part. Syst. Char. 33(1), 53–62 (2016).
    • 28 Xu Q, Leong J, Chua QY et al. Combined modality doxorubicin-based chemotherapy and chitosan-mediated p53 gene therapy using double-walled microspheres for treatment of human hepatocellular carcinoma. Biomaterials 34(21), 5149–5162 (2013).
    • 29 Ping H, Qian X, Yu C et al. Metalloporphyrin-encapsulated biodegradable nanosystems for highly efficient magnetic resonance imaging-guided sonodynamic cancer therapy. J. Am. Chem. Soc. 139(3), 1275–1284 (2017).
    • 30 Yao X, Niu X, Ma K et al. Graphene quantum dots-capped magnetic mesoporous silica nanoparticles as a multifunctional platform for controlled drug delivery, magnetic hyperthermia, and photothermal therapy. Small 13(2), 1602225 (2017).
    • 31 Tian Z, Yao X, Ma K et al. Metal–organic framework/graphene quantum dot nanoparticles used for synergistic chemo- and photothermal therapy. ACS Omega 2(3), 1249–1258 (2017).
    • 32 Yao X, Tian Z, Liu J, Zhu Y, Hanagata N. Mesoporous silica nanoparticles capped with graphene quantum dots for potential chemo–photothermal synergistic cancer therapy. Langmuir 33(2), 591–599 (2017).
    • 33 Tao C, Zhu Y. Magnetic mesoporous silica nanoparticles for potential delivery of chemotherapeutic drugs and hyperthermia. Dalton T. 43(41), 15482–15490 (2014).
    • 34 Tian Z, Yu X, Ruan Z, Zhu M, Zhu Y, Hanagata N. Magnetic mesoporous silica nanoparticles coated with thermo-responsive copolymer for potential chemo- and magnetic hyperthermia therapy. Micropor. Mesopor. Mater. 256, 1–9 (2018).
    • 35 Liu T, Wang C, Gu X et al. Drug delivery with PEGylated MoS2 nano-sheets for combined photothermal and chemotherapy of cancer. Adv. Mater. 26(21), 3433–3440 (2014).
    • 36 Li Z, Hu Y, Howard KA et al. Multifunctional bismuth selenide nanocomposites for antitumor thermo-chemotherapy and imaging. ACS Nano 10(1), 984–997 (2016).
    • 37 Li Z, Hu Y, Chang M et al. Highly porous PEGylated Bi2S3 nano-urchins as a versatile platform for in vivo triple-modal imaging, photothermal therapy and drug delivery. Nanoscale 8(35), 16005–16016 (2016). •• Illustrates a successful example of porous PEGylated Bi2S3 nanourchins for in vivo triple-modal imaging, photothermal therapy and drug delivery.
    • 38 Liang X, Li Y, Li X et al. PEGylated polypyrrole nanoparticles conjugating gadolinium chelates for dual-modal MRI/photoacoustic imaging guided photothermal therapy of cancer. Adv. Funct. Mater. 25(9), 1451–1462 (2015).
    • 39 Yi X, Yang K, Liang C et al. Imaging-guided combined photothermal and radiotherapy to treat subcutaneous and metastatic tumors using Iodine-131-doped copper sulfide nanoparticles. Adv. Funct. Mater. 25(29), 4689–4699 (2015).
    • 40 Song G, Liang C, Gong H et al. Core–shell MnSe@Bi2Se3 fabricated via a cation exchange method as novel nanotheranostics for multimodal imaging and synergistic thermoradiotherapy. Adv. Mater. 27(40), 6110–6117 (2015). • Illustrates a successful example of core–shell Bi based nanoparticles for multimodal imaging and synergistic thermoradiotherapy.
    • 41 Zhang Z, Wang L, Wang J et al. Mesoporous silica–coated gold nanorods as a light-mediated multifunctional theranostic platform for cancer treatment. Adv. Mater. 24(11), 1418–1423 (2012).
    • 42 Cheng L, Liu J, Gu X et al. PEGylated WS2 nanosheets as a multifunctional theranostic agent for in vivo dual-modal CT/photoacoustic imaging guided photothermal therapy. Adv. Mater. 26(12), 1886–1893 (2014).
    • 43 Li Z, Zeng Y, Zhang D et al. Glypican-3 antibody functionalized Prussian blue nanoparticles for targeted MR imaging and photothermal therapy of hepatocellular carcinoma. J. Mater. Chem. B 2(23), 3686–3696 (2014).
    • 44 Yang K, Zhang S, Zhang G, Sun X, Lee ST, Liu Z. Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy. Nano Lett. 10(9), 3318–3323 (2010).
    • 45 Yang T, Wang Y, Ke H et al. Protein-nanoreactor-assisted synthesis of semiconductor nanocrystals for efficient cancer theranostics. Adv. Mater. 28(28), 5923–5930 (2016).
    • 46 Xie J, Lee JY, Wang DI. Seedless, surfactantless, high-yield synthesis of branched gold nanocrystals in HEPES buffer solution. Chem. Mater. 19(11), 2823–2830 (2007).
    • 47 Zhang C, Fu YY, Zhang X, Yu C, Zhao Y, Sun SK. BSA-directed synthesis of CuS nanoparticles as a biocompatible photothermal agent for tumor ablation in vivo. Dalton T. 44(29), 13112–13118 (2015).
    • 48 Li Z, Liu J, Hu Y et al. Biocompatible PEGylated bismuth nanocrystals: 'all-in-one' theranostic agent with triple-modal imaging and efficient in vivo photothermal ablation of tumors. Biomaterials 141, 284–295 (2017).
    • 49 You J, Zhang G, Li C. Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared light-triggered drug-release. ACS Nano 4(2), 1033–1041 (2010).
    • 50 Ito A, Shinkai M, Honda H et al. Heat shock protein 70 expression induces antitumor immunity during intracellular hyperthermia using magnetite nanoparticles. Cancer Immunol. Immun. 52(2), 80–88 (2003).
    • 51 Brown AL, Naha PC, Benavides-Montes V, Litt HI. Synthesis, x-ray opacity, and biological compatibility of ultra-high payload elemental bismuth nanoparticle x-ray contrast agents. Chem. Mater. 26(7), 2266–2274 (2014).
    • 52 Sherlock SP, Tabakman SM, Xie L, Dai H. Photothermally enhanced drug delivery by ultra-small multifunctional FeCo/graphitic-shell nanocrystals. ACS Nano 5(2), 1505–1512 (2011).
    • 53 Roper DK, Ahn W, Hoepfner M. Microscale heat transfer transduced by surface plasmon resonant gold nanoparticles. J. Phys. Chem. C. 111(9), 3636–3641 (2007).
    • 54 Hessel CM, Pattani VP, Rasch M et al. Copper selenide nanocrystals for photothermal therapy. Nano Lett. 11(6), 2560–2566 (2011).
    • 55 Wang C, Xu H, Liang C et al. Iron oxide@polypyrrole nanoparticles as a multifunctional drug carrier for remotely controlled cancer therapy with synergistic antitumor effect. ACS Nano 7(8), 6782–6795 (2013).
    • 56 Shen P, Hawksworth J, Lovato J et al. Cytoreductive surgery and intraperitoneal hyperthermic chemotherapy with mitomycin C for peritoneal carcinomatosis from nonappendiceal colorectal carcinoma. Ann. Surg. Oncol. 11(2), 178–186 (2004).
    • 57 Li J, Jiang F, Yang B et al. Topological insulator bismuth selenide as a theranostic platform for simultaneous cancer imaging and therapy. Sci. Rep. 3(6), 1998 (2013).
    • 58 Liu J, Zheng X, Yan L et al. Bismuth sulfide nanorods as a precision nanomedicine for in vivo photothermal therapy of tumor. ACS Nano 9(1), 696–707 (2015).
    • 59 Kim D, Park S, Lee JH, Jeong YY, Jon S. Antibiofouling polymer-coated gold nanoparticles as a contrast agent for in vivo x-ray computed tomography imaging. J. Am. Chem. Soc. 129(24), 7661–7665 (2007).
    • 60 Ke H, Yue X, Wang J et al. Gold nanoshelled liquid perfluorocarbon nanocapsules for combined dual modal ultrasound/CT imaging and photothermal therapy of cancer. Small 10(6), 1220–1227 (2014).