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Pharmacogenetic guidelines and decision support tools for depression treatment: application to late-life

    Donald D Chang

    School of Medicine, University of Queensland-Ochsner Clinical School, Brisbane, Queensland, 4072, Australia

    ,
    Harris A Eyre

    *Author for correspondence:

    E-mail Address: harris.eyre@gmail.com

    Innovation Institute, Texas Medical Center, Houston, TX 77006, USA

    IMPACT SRC, School of Medicine, Deakin University, Geelong, Victoria, 3220, Australia

    Department of Psychiatry, University of Melbourne, Melbourne, Victoria, 3003, Australia

    Discipline of Psychiatry, University of Adelaide, Adelaide, South Australia, 5055, Australia

    ,
    Ryan Abbott

    University of Surrey, Surrey, GU2 7XH, UK

    David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA

    ,
    Michael Coudreaut

    Department of Psychiatry, Intermountain Healthcare, Salt Lake City, UT 84102, USA

    ,
    Bernhard T Baune

    Discipline of Psychiatry, University of Adelaide, Adelaide, South Australia, 5055, Australia

    ,
    Jeffrey A Shaman

    Coriell Life Sciences, Philadelphia, PA 19112, USA

    ,
    Helen Lavretsky

    David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA

    ,
    Eric J Lenze

    Department of Psychiatry, Washington University, St Louis, MO 63130, USA

    ,
    David A Merrill

    David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA

    ,
    Ajeet B Singh

    IMPACT SRC, School of Medicine, Deakin University, Geelong, Victoria, 3220, Australia

    ,
    Benoit H Mulsant

    Department of Psychiatry, University of Toronto, Toronto, ON, M5S 3H7, Canada

    Campbell Family Mental Health Research Institute, Centre for Addiction & Mental Health, Toronto, ON, M5S 3H7, Canada

    ,
    Charles F Reynolds

    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15260, USA

    ,
    Daniel J Müller

    Department of Psychiatry, University of Toronto, Toronto, ON, M5S 3H7, Canada

    Campbell Family Mental Health Research Institute, Centre for Addiction & Mental Health, Toronto, ON, M5S 3H7, Canada

    &
    Chad Bousman

    Departments of Medical Genetics, Psychiatry, & Physiology & Pharmacology, University of Calgary, Calgary, AB, AN T2N 1N4, Canada

    Published Online:https://doi.org/10.2217/pgs-2018-0099

    Late-life depression (LLD) is a major depressive disorder that affects someone after the age of 60 years. LLD is frequently associated with inadequate response and remission from antidepressants, in addition to polypharmacy. Pharmacogenetics offers a promising approach to improve clinical outcomes in LLD via new discoveries determining the genetic basis of response rates and side effects, as well as the development of tailored pharmacogenetic-based decision support tools. This invited review evaluates the LLD pharmacogenetic evidence base and the extent to which this was incorporated into existing commercial decision support tools and clinical pharmacogenetic guidelines.

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