Photosensitizing Properties of Compounds Related to Benzophenone

Authors

  • Marianne Placzek
  • Markus Dendorfer
  • Bernhard Przybilla
  • Klaus-P. Gilbertz
  • Bernadette Eberlein

DOI:

https://doi.org/10.2340/00015555-1421

Keywords:

benzophenone, phototoxicity, photohaemolysis test.

Abstract

Benzophenone is a phototoxic compound with absorption maxima in the ultraviolet A (UVA) and ultraviolet B (UVB) range. Many benzophenone derivatives are known to be photosensitizing. On the other hand, 2-hydroxy-4-methoxybenzophenone is used as a photoprotective agent. The aim of the present study was to analyse a range of benzophenone derivatives and thus examine the effects of molecular changes in the benzophenone molecule on phototoxic behaviour. Phototoxicity was tested by an in vitro photohaemolysis test. The tested compounds were benzophenone itself and the derivatives 2-hydroxybenzophenone, 2-aminobenzophenone, 2-benzoylbenzoic acid, 3-hydroxybenzophenone, and 4-hydroxybenzo-phenone, as well as the structurally similar compounds 9-fluorenone, 9-fluorenone-2-carboxylic acid, cyclohexyl phenyl ketone, and 1,4-naphtho-quinone. It was shown that minor changes in molecular structure can result in highly different phototoxic characteristics.

Downloads

Download data is not yet available.

Downloads

Additional Files

Published

2012-09-11

How to Cite

Placzek, M., Dendorfer, M., Przybilla, B., Gilbertz, K.-P., & Eberlein, B. (2012). Photosensitizing Properties of Compounds Related to Benzophenone. Acta Dermato-Venereologica, 93(1), 30–32. https://doi.org/10.2340/00015555-1421

Issue

Section

Articles