Hair Zinc Levels and the Efficacy of Oral Zinc Supplementation in Patients with Atopic Dermatitis

Authors

  • Jeong Eun Kim
  • Seo Rye Yoo
  • Myeong Gil Jeong
  • Joo Yeon Ko
  • Young Suck Ro

DOI:

https://doi.org/10.2340/00015555-1772

Keywords:

atopic dermatitis, hair, zinc.

Abstract

Zinc deficiency in patients with atopic dermatitis (AD) and the use of zinc supplementation is still controversial. We measured hair zinc levels in 58 children with AD and 43 controls (age range 2–14 years). We also investigated the efficacy of oral zinc supplementation in AD patients with low hair zinc levels by comparing eczema assessment severity index (EASI), transepidermal water loss (TEWL), and visual analogue scales for pruritus and sleep disturbance in patients receiving zinc supplementation (Group A) and others not receiving supplementation (Group B). At baseline, the mean zinc level was significantly reduced in AD patients (113.1g/g vs. 130.9g/g, p=0.012). After 8 weeks of supplement, hair zinc level increased significantly in Group A (p<0.001), and EASI scores, TEWL, and visual analogue scales for pruritus improved more in Group A than in Group B (p=0.044, 0.015 and <0.001, respectively). Thus, oral zinc supplementation may be effective in AD patients with low hair zinc levels.

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Published

2013-12-16

How to Cite

Eun Kim, J., Rye Yoo, S., Gil Jeong, M., Yeon Ko, J., & Suck Ro, Y. (2013). Hair Zinc Levels and the Efficacy of Oral Zinc Supplementation in Patients with Atopic Dermatitis. Acta Dermato-Venereologica, 94(5), 558–562. https://doi.org/10.2340/00015555-1772

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Section

Articles