Familial Melanoma Associated with Li-Fraumeni Syndrome and Atypical Mole Syndrome: Total-body Digital Photography, Dermoscopy and Confocal Microscopy

Authors

  • Priscila Giavedoni
  • Marnie Ririe
  • Cristina Carrera
  • Susana Puig
  • Josep Malvehy

DOI:

https://doi.org/10.2340/00015555-2639

Keywords:

familial melanoma, Li-Fraumeni syndrome, atypical mole syndrome, digital total-body, photography, dermo�scopy, confocal microscopy

Abstract

Li-Fraumeni syndrome (LFS) is a rare autosomal dominant disorder caused by a mutation in the p53 gene. Melanoma is considered to be a rare, controversial component of LFS. The aim of this study is to describe the utility of systematic screening for melanoma in patients with LFS and atypical mole syndrome. Two 28-year-old identical twin sisters with LFS and atypical moles were monitored by physical examination, total-body digital photography and dermoscopy be?tween 2006 and 2014. A total of 117, predominantly dark-brown, reticular naevi were identified on case 1 and 105 on case 2. Excisions were performed during the evaluation period of 1 in-situ melanoma and 3 basal cell carcinomas in case 1, and 1 in-situ melanoma and 1 early invasive melanoma in case 2. The remaining melanocytic lesions in both patients were stable during follow-up. The 3 melanomas were new atypical lesions detected with total-body photography and dermoscopy. In conclusion, monitoring LFS patients with total-body photography and dermoscopy may be useful to detect early melanoma.

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Published

2017-03-23

How to Cite

Giavedoni, P., Ririe, M., Carrera, C., Puig, S., & Malvehy, J. (2017). Familial Melanoma Associated with Li-Fraumeni Syndrome and Atypical Mole Syndrome: Total-body Digital Photography, Dermoscopy and Confocal Microscopy. Acta Dermato-Venereologica, 97(6), 720–723. https://doi.org/10.2340/00015555-2639

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Articles