ORIGINAL ARTICLE   

Minerva Medica 2020 December;111(6):544-50

DOI: 10.23736/S0026-4806.20.06532-5

Copyright © 2020 EDIZIONI MINERVA MEDICA

language: English

Expression and clinical value of miR-128 and IGF-1 in patients with acute ischemic stroke

Shanshan LI ¹, Youxu ZHAO ² ✉, Jing ZHAO ³, Lei MOU ⁴

¹ Department of Encephalopathy II, Rizhao Hospital of Traditional Chinese Medicine, Rizhao, China; ² Ju County Hospital of Traditional Chinese Medicine, Rizhao, China; ³ Zibo Central Hospital, Zibo, China; ⁴ Department of Neurology, Rizhao Hospital of Traditional Chinese Medicine, Rizhao, China

BACKGROUND: The aim of this study is to investigate the expression and clinical value of miRNA-128 (miR-128) and insulin-like growth factor-1 (IGF-1) in patients with acute ischemic stroke (AIS).
METHODS: Eighty patients with acute ischemic stroke hospitalized in Rizhao Hospital of TCM from August 2016 to August 2018 were selected as the experimental group. Sixty healthy patients with normal physical examination during the same period were selected as the control group. The expression levels of miR-128 and IGF-1 were compared between the two groups and between AIS patients with different levels of nervous functional defects, different infarct size and different prognosis. ROC curve of serum miR-128 and IGF-1 expressions for AIS diagnosis alone and in combination was analyzed.
RESULTS: The expression level of miR-128 in the serum of patients in the experimental group was higher than that of the control group, and the expression level of IGF-1 was lower than that of the control group (P<0.001). The serum miR-128 expression of patients in the ineffective group was higher than that of the effective group, and the expression of IGF-1 was lower than that of the effective group (P<0.001). The expression level of serum miR-128 in AIS patients was higher than that in healthy subjects and increased with the aggravation of the disease. The expression level of IGF-1 of AIS patients was lower than that of healthy subjects and decreased with the aggravation of the disease. The two factors were involved in the formation and deterioration of the disease.
CONCLUSIONS: The expression levels can reflect the severity of the disease to a certain extent and provide references for the early diagnosis and prognostic treatment in patients with acute ischemic stroke.

KEY WORDS: Human MIRN128 microRNA; Insulin-like growth factor I; Ischemia; Stroke; MicroRNAs