REVIEW  CEREBRAL GLIOMA IN HIGHLY ELOQUENT AREAS: MANAGEMENT AND OUTCOME 

Journal of Neurosurgical Sciences 2019 April;63(2):179-86

DOI: 10.23736/S0390-5616.18.04610-6

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

The algorithms of adjuvant therapy in gliomas and their effect on survival

Christoph STRAUBE ^{1, 2}, Friederike SCHMIDT-GRAF ³, Benedikt WIESTLER ⁴, Claus ZIMMER ⁴, Bernhard MEYER ⁵, Stephanie E. COMBS ^{1, 2, 6} ✉

¹ Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich (TUM), Munich, Germany; ² German Consortium for Translational Cancer Research (DKTK), Partner Site Munich, Munich, Germany; ³ Department of Neurology, Klinikum rechts der Isar, Technical University of Munich (TUM), Munich, Germany; ⁴ Department of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich (TUM), Munich, Germany; ⁵ Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich (TUM), Munich, Germany; ⁶ Department of Radiation Sciences (DRS), Institute for Innovative Radiotherapy (iRT), Helmholtz Zentrum München, Munich, Germany

The treatment of gliomas became more sophisticated during the last decades. As by now, adjuvant treatment after maximum safe resection is considered an important and effective treatment strategy in most gliomas, yet the decision is based on several factors. This review summarizes the available evidence for the current adjuvant treatment algorithms with a focus on the impact on the survival of glioma patients. The review is based on the current guidelines, but it also includes new insights which have not yet been included into the official guidelines.

KEY WORDS: Glioma - Glioblastoma - Oligodendroglioma - Adjuvant radiotherapy