HUBUNGAN KADAR FIBRINOGEN PLASMA DAN MIKROALBUMINURIA PADA PENDERITA DIABETES MELLITUS TIPE 2

Abstract

Increase of fibrinogen concentration in type 2 diabetic patients is an indicator for vascular inflammation, endothelial dysfunction.
Hyperfibrinogenemia is a strong marker and independently for atherosclerosis. Beside that, hyperfibrino -genemia can precede macro
and microvascular complication. In type 2 diabetic, microalbuminuria is early marker for diabetic nephropathy and show that there is
endothelial dysfunction. Microalbuminuria not only useful to predict renal damage, but also useful to predict cardiovascular damage.
Microalbuminuria is a marker for endothelial dysfunction. To know the correlation between increase of fibrinogen concentration and
microalbuminuria in type 2 diabetic patients. The study was performed in Dr. M. Djamil central Hospital by using cross sectional
method and consecutive random sampling. Sample were type 2 diabetic patients included criteria were measured albumin/ creatinine
ratio and the patients was divided in 2 group, that is group A (normoalbuminuria) and group B (microalbuminuria) with total
sample were 90 patients. Each group were performed measurement of albumin/ creatinine ratio, random glucose concentration, and
fibrinogen concentration in plasma. In group A, we found the average of albumin/ creatinine ratio is 6.6 μg/mg and in group B is
107.5 μg/mg. The average of random glucose concentration in group A is 181.3 mg/dl, and in group B is 204 mg/dl and the difference
of concentration is not significantly (p > 0.05). The average of fibrinogen concentration in group A is 383.5 ± 104.6 mg/dl, and in
group B is 467 ± 79 mg/dl. Increasing fibrinogen concentration in group B is higher than group A and the increasing is significantly
statistical difference (p <0.05). In this study we also founded the positive correlation between concentration of fibrinogen plasma and
albuminuria ( r = 0.036, p =0.0004). In type 2 diabetic patients with normoalbuminuria has been increased fibrinogen concentration,
and the increasing of fibrinogen concentration in type 2 diabetic patients with microalbuminuria is higher than type 2 diabetic patients
with normoalbuminuria. There are positive correlation between fibrinogen plasma concentration and albumin/creatinine ratio