In recent years, employeesʼ side jobs have been attracting attention. According to the Japanese Panel Study of Employment Dynamics 2021 (Recruit Works Institute), 12.1% of employees have side jobs, and 34.2% of employees said they would like to have side jobs in the future. In addition, according to the 2nd quantitative survey on the side jobs (Persol Research and Consulting Co., Ltd., 2021), 23.7% of companies fully approve of side jobs and 31.3% approve of them with conditions, with the total approval rate exceeding 50%. The Ministry of Health, Labor and Welfare (MHLW) established the “Guidelines for promoting side jobs/part-time jobs” in 2018 (revised in 2022), which recognizes the significance of side jobs/part-time jobs as an effective means of open innovation and entrepreneurship for society as a whole, as well as contributing to regional development from the perspective of utilizing human resources in urban areas. In this paper, I attempt to examine the impact of side jobs and hybrid entrepreneurship. As a result of examining the impact of side jobs on entrepreneurship using the Japanese Panel Study of Employment Dynamics from 2017 to 2021 (Recruit Works Institute), it demonstrated that hybrid entrepreneurs encourage to transfer to fulltime entrepreneurs. However, side jobs other than self-employment had no statistical effect on the encouragement of entrepreneurship.