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BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access February 21, 2014

Regio- and stereoselectivity of polar [2+3] cycloaddition reactions between (Z)-C-(3,4,5-trimethoxyphenyl)-N-methylnitrone and selected (E)-2-substituted nitroethenes

  • Radomir Jasiński EMAIL logo , Magda Ziółkowska , Oleh Demchuk and Agata Maziarka
From the journal Open Chemistry

Abstract

[2+3] Cycloaddition reactions of the highly reactive (Z)-C-(3,4,5-trimethoxyphenyl)-N-methylnitrone with (E)-2-R-nitroethenes proceed under mild conditions and yield mixtures of stereoisomeric 2-methyl-3-(3,4,5-trimethoxyphenyl)-4-nitro-5-R-isoxazolidines. The effect of regiospecificity of the cycloadditions may be accounted for by the theory of electrophilicity indexes. Stereoselectivity, however, is determined by a compilation of steric and secondary orbital effects.

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Published Online: 2014-2-21
Published in Print: 2014-5-1

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