The first phase of this study was undertaken using Participatory Action Research (PAR) to identify the factual situations of fabric-weaving women working in the informal sector in Thailand. The aims were to enhance the mutual understanding of the women and researchers concerning the problems faced by these women and to establish an action plan to address these problems. The participant group consisted of 107 women working in the informal sector from three local villages who voluntarily took part in the study. Data were collected using quantitative and qualitative methods through structured questionnaires, focus groups, in-depth interviews, participant observations, and field notes. The results of the study revealed that the women learned their health problems were related to work and their labor potentially placed them at a risk for illness. When the women realized the gravity of their situation, they attained a sense of empowerment and took the initiative in establishing action plans to address their problems.