Tetrode optic flow track, supporting "Distance-tuned neurons drive specialized path integration calculations in medial entorhinal cortex"

Data presented here is part of the study "Distance-tuned neurons drive specialized path integration calculations in medial entorhinal cortex" (https://doi.org/10.1016/j.celrep.2021.109669). It consists of recordings of MEC neurons in mice while mice are running down a virtual linear track. Recordings were performed with tetrodes. Furthermore, cells were characterized while mice were freely foraging in an open field environment. For more details, see "Principles governing the integration of landmark and self-motion cues in entorhinal cortical codes for navigation" by Campbell et al, (https://doi.org/10.1038/s41593-018-0189-y). Detailed description of data below.

Each .mat file corresponds to data from one cell recorded in one session.

The titles are structured as follows:

____.mat

For example,

Ariana_0830_opticflow_1_T1C1.mat

Inside each .mat file is a structure called celldata, which has the following fields:

unique_id: Unique ID of the cell

mouse: Mouse name

session: Session name

cell: Tetrode and cluster of the cell

session_type: Session type

speed_cutoff: Speed cutoff used to compute firing rate maps, in cm/s

track_length: Length of the track, in cm

track_start: Location of the start of the track, in cm

track_end: Location of the end of the track, in cm

binsize: Size of the spatial bin for firing rate maps, in cm

nbins: Number of spatial bins in the firing rate map

binedges: Edges of the spatial bins for the firing rate maps, in cm

numblocks: Number of blocks

ws: Structure with whole session data, explained below

bl: Structure with data split by trial blocks (ignore this for optic flow data)

of_data: Structure with statistics computed from open field recordings from the same cell. Cells were matched manually by matching waveforms between open field and VR recordings.

The ws ("whole session") structure has the following fields, all computed from VR data:

posx: Position of the mouse on the VR track in each time bin

post: Time of each time bin, in seconds

lickx: Lick locations

lickt: Lick time stamps

trialt: Start time of each trial, in seconds

trial: Current trial of each time bin

trialtype: Type of each trial

trialgainvalues: VR gain of each trial

recording_length: Recording length in seconds

dt: Length of each VR frame, in seconds

trialblock: Trialblock number of each time bin

blocktype: Type of each trial block

blockgain: VR gain of each trial block

trialsperblock: Number of trials per block

gain: VR gain of each time bin

vrspeed: VR speed at each time bin (in VR cm/sec)

realspeed: Real speed at each time bin (VR speed/gain) (in cm/sec)

meanspeed: Mean real speed in the session (cm/sec)

posx_filt: Same as posx, but filtered to only include time bins above the speed threshold

post_filt: Same as post, but filtered to only include time bins above the speed threshold

trial_filt: Same as trial, but filtered to only include time bins above the speed threshold

trialblock_filt: Same as trialblock, but filtered to only include time bins above the speed threshold

gain_filt: Same as gain, but filtered to only include time bins above the speed threshold

dt_filt: Same as dt, but filtered to only include time bins above the speed threshold

spike_t: Spike times

spike_idx: Time bin index for each spike

spike_t_filt: Spike times, filtered to only include spikes when speed was above the speed threshold

spike_idx_filt: Time bin index for each spike, filtered to only include spikes when speed was above the speed threshold

The bl ("block") structure is analogous to the ws structure but split by trial blocks, e.g. with different VR gain. This is irrelevant for optic flow data.

The of_data structure has the following fields, all computed from matched open field data (see Methods of Campbell et al. 2018 for description of how they were computed):

grid_score: Grid score

border_score: Border score

hd_score: Head direction score

speed_score: Speed score

mean_rate: Mean firing rate

stability: Spatial stability

coherence: Spatial coherence

coverage: Percentage of open field box covered (percent of bins)

box_size: Length of the edge of the square open field box, in cm