Antidiabetic Activity of Medicinal Plants: An Updated Overview of Streptozotocin and Alloxan-Induced Diabetic Models
doi.org/10.26538/tjnpr/v6i7.3
Keywords:
Traditional uses., Streptozotocininduced model, Medicinal plants, Antidiabetic activity, Alloxan-induced modelsAbstract
Insulin resistance (type 2 diabetes mellitus) leads to the development of hyperglycemia. The present review was aimed at providing an overview of current traditional antidiabetic medicinal plants evaluated by streptozotocin and alloxan. A total of seventy medicinal plants were mentioned with antidiabetic activities in the streptozotocin-induced diabetic model (thirty-six), and alloxan-induced diabetic model (thirty-four). Also, the presence of active ingredients, dose, and significance of antidiabetic action of the medicinal plants were evaluated. In this review, the herbal plants for the treatment of diabetes in the majority of the plants found in Nigeria have
been highlighted, and the efficacy of the seventy herbs in the management of diabetes has been evaluated. Diabetes is treated with approximately 40% of medicinal plant leaves. Based on the findings of this review, it is possible to use herbs as adjuvant therapies in the management and treatment of diabetes. Further research into the isolation of phytochemicals and their mechanisms of action will lead to the discovery of newer antidiabetic agents.
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