Abstract
The association of the Asp298Asn polymorphism in the mc4r gene with the development of traites such as spinal fat thickness in pigs of the Large White breed from AF “Orzhitska” population was investigated. A tendency towards the development of thinner spinal fat was found in animals with the AG genotype. No significant difference was detected in the spinal fat thickness between animal groups with different genotypes of the mc4r gene caused by Asp298Asn polymorphism. The heterogeneous origin of the studied animals can be a possible cause of the absence of any statistically significant difference. A conclusion was reached that it was not expedient to use Asp298Asn polymorphism of the mc4r gene in the selection of pigs of the Large White breed from AF “Orzhitska” population.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Kim, K.S., Lee, J.J., Shin, H.Y., et al., Association of Melanocortin 4 Receptor (MC4R) and High Mobility Group AT-Hook 1 (HMGA1) Polymorphisms with Pig Growth and Fat Deposition Traits, Anim. Genet., 2006, pp. 419–421.
Pankov, Yu.A., Leptin-A New Hormone in Endocrinology, Usp. Fiziol. Nauk, 2003, vol. 34, no. 2, pp. 3–20.
Gantz, I., Miwa, H., Konda, Y., Shimoto, Y., Tashiro, T., Watson, S.J., Del Valle, J., and Yamada, T., Molecular Cloning, Expression, and Gene Localization of a Fourth Melanocortin Receptor, J. Biol. Chem., 1993, vol. 268, no. 20, pp. 15174–15179.
Wikberg, J.E.C., Muceniece, R., Mandrika, L., Prusis, P., Lindblom, J., Post, C., and Skottner, A., New Aspects on the Melanocortins and Their Receptors, Pharm. Res., 2000, vol. 42, no. 5, pp. 393–420.
Wikberg, J.E.G., Melanocortin Receptors: Perspectives for Novel Drugs, Eur. J. Pharm., 1999, vol. 375, nos. 1/3, pp. 295–310.
Kim, K.S., Larsen, N.J., and Rothschild, M.F., Rapid Communication: Linkage and Physical Mapping of the Porcine Melanocortin-4 Receptor (MC4R) Gene, J. Anim. Sci., 2000, vol. 78, pp. 791–792.
Houston, R.D., Cameron, N.D., and Rance, K.A., AMelanocortin4 Receptor (MC4R) Polymorphism Is Associated with Performance Traits in Divergently Selected Large White Pig Populations, Anim. Genet., 2004, vol. 35, pp. 386–390.
Kim, K.S., Larsen, N., Short, T., Plastow, G., and Rothschild, M.F., A Missense Variant of the Porcine Melanocortin 4 Receptor (MC4R) Gene Is Associated with Fatness, Growth, and Feed Intake Traits, Mammalian Genome, 2000, vol. 11, pp. 131–135.
Barb, C.R., Robertson, A.S., Barrett, J.B., Kraeling, R.R., and Houseknecht, K.L., The Role of Melanocortin-3 and -4 Receptor in Regulating Appetite, Energy Homeostasis and Neuroendocrine Function in the Pig, J. Endocrinol., 2004, vol. 181, pp. 39–52.
Bruun, C.S., Jorgensen, C.B., Nielsen, V.H., Andersson, L., and Fredholm, M., Evaluation of the Porcine Melanocortin 4 Receptor (MC4R) Gene as a Positional Candidate for a Fatness QTL in a Cross between Landrace and Hampshire, Anim. Genet., 2006, vol. 37, pp. 359–362.
Park, H.B., Carlborg, O., Marklund, S., and Andersson, L., Melanocortin 4 Receptor (MC4R) Genotypes Have No Major Effect on Fatness in a Large White X Wild Boar Intercross, Anim. Genet., 2002, vol. 33, pp. 155–157.
Huszar, D., Lynch, C.A., Fairchild-Huntress, V., et al., Targeted Disruption of the Melanocortin 4 Receptor Results in Obesity in Mice, Cell, 1997, vol. 88, pp. 131–141.
Farooqi, I.S., Keogh, J.M., Yeo, G.S., Lank, E.J., Cheetham, T., and O’Rahilly, S., Clinical Spectrum of Obesity and Mutations in the Melanocortin 4 Receptor Gene, N. Engl. J. Med., 2003, vol. 348, pp. 1085–1095.
Willeke, H., Getya, A., and Chub, O., Methodology for Integrated Assessment of Repair Young Pigs with their Own Performance under Husbandry Conditions, Modern Research Methods in Pig Breeding, Poltava, 2005, pp. 38–40.
Korinnii, S.M., Pochernyav, K.F., and Balats’kii, V.M., Animal Fur as a Convenient Object for DNA Isolation for Subsequent PCR Analysis, Veterinar. Biotekhnol., 2005, no. 7, pp. 80–83.
Peakall, R. and Smouse, P.E., GENALEX 6: Genetic Analysis in Excel. Population Genetic Software for Teaching and Research, Mol. Ecol. Notes, 2006, vol. 6, pp. 288–295.
Getya, A.A., Berezovskii, N.D., Pochernyaev, K.F., and Lyadskii, I.K., Assessment of Asp298Asn Polymorphism of the MC4R Gene in Pigs of Large White Breed, Tavr. Nauk. Visn.: Zb. Nauk. Pr. KhDAU, Kherson: Ailant, 2008, vol. 58, no. 2, pp. 45–49.
Bruun, C.S., Jorgensen, C.B., Nielsen, V.H., et al., Evaluation of the Porcine Melanocortin 4 Receptor (MC4R) Gene as a Positional Candidate for a Fatness QTL in a Cross between Landrace and Hampshire, Anim. Genet., 2006, vol. 37, pp. 359–362.
Luikart, G. and Comuet, J.M., Empirical Evaluation of a Test for Identifying Recently Bottlenecked Populations from Allele Frequency Data, Conserv. Biol., 1998, vol. 12, no. 1, pp. 228–237.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © I.K. Lyadskiy, A.A. Getya, K.F. Pochernyaev, 2011, published in Tsitologiya i Genetika, 2011, Vol. 45, No. 2, pp. 52–56.
About this article
Cite this article
Lyadskiy, I.K., Getya, A.A. & Pochernyaev, K.F. Association of the Asp298Asn polymorphism in the mc4r gene with back fat thickness in pigs of the large white breed. Cytol. Genet. 45, 106–109 (2011). https://doi.org/10.3103/S0095452711020083
Received:
Published:
Issue Date:
DOI: https://doi.org/10.3103/S0095452711020083